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Membrane, Morphology and Function

5—8 May 2014

Hotel del Camerlengo, Fara San Martino, Abruzzo, Italy



Meeting background

 

The functions of cells that lead to the exquisite processes of organismal development rely on communication. Signals are necessary for cells to communicate and cooperate with each other, alter their programs of gene expression and fates, and reorganise themselves into a diversity of shapes and sizes. Most of these signalling pathways travel across cell membranes. Due to the advances in the analytical tools, which can be applied to membrane morphology, new opportunities exist now to understand these signalling mechanisms.  

 

The three disciplines of membrane biophysics, cell biology and lipid signalling have not been proposed in a single focused meeting. Our intension is to link the biophysical aspects of membrane dynamics with lipid signalling and cell biology; in such a manner that researchers in lipid signalling and cell biology can benefit from the advances made in membrane biophysics and conversely researchers in membrane biophysics can see more clearly where the critical questions in cell biology and lipid signalling reside. The meeting will emphasise the diversity and complexity of membrane morphology and functions in the context of different physiological and pathological conditions.  

 

This cross-disciplinary milieu will provoke dialogue amongst senior biophysicists and set an environment for cell biologists to discuss and propose various ideas to membrane biophysicists. The young researchers will benefit immensely from the emergence of novel insights from previously unrealised or unconnected parts, hoping that it will lead to creative impulse.

 

Organizers:
Banafshe Larijani (IKERBASQUE, Basque Foundation for Science and Unidad de Biofísica (CSIC-UPV/EHU), University of the Basque Country,Spain)
Marco Falasca (Barts and The London School of Medicine and Dentistry, United Kingdom)
Monday 5 May 2014
16:30 - 19:30 Arrival and Registration

19:30 - 21:00 Dinner

21:00 Opening Remarks

Session 1

 

Chair:
Vytas Bankaitis (Texas A&M Health Science Center, U.S.A.)
Tuesday 6 May 2014
09:00 - 09:30
Lipidomics methodologies and their use in studying cancer
Michael Wakelam (The Babraham Institute, United Kingdom)
09:30 - 10:00
The role of PI3P and WIPI2 in autophagy
Sharon Tooze (Lincoln‘s Inn Fields Laboratories, United Kingdom)
10:00 - 10:15
Systems analysis of fatty liver gene expression and membrane lipidomics unveils a protective role for MacroH2A1.1 in hepatocyte against lipid accumulation
Selected Oral Communication - Manlio Vinciguerra (University College London, United Kingdom)
10:15 - 10:30
Lipid droplet and early autophagosomal membrane targeting of Atg2A and Atg14L in human tumor cells
Selected Oral Communication - Daniela Bakula (Eberhard Karls University Tübingen, Germany)
10:30 - 10:50 Coffee/Tea Break

10:50 - 11:20
Effects of Phosphoinositides and their Derivatives on Membrane Morphology and Function
Banafshe Larijani (IKERBASQUE, Basque Foundation for Science and Unidad de Biofísica (CSIC-UPV/EHU), University of the Basque Country,Spain)
11:20 - 11:35
Characterisation of the PLD2 ko mouse – implications for lipid metabolism and membrane biology
Selected Oral Communication - Richard D. Byrne
11:35 - 11:50
Elucidating the interactions of peripheral proteins with model membranes containing zwitterionic lipids and phosphatidyl inositol phosphates via multi-scale simulations.
Selected Oral Communication - Antreas Kalli (University of Oxford, United Kingdom)
11:50 - 12:20
Chemical tools to probe phosphoinositide dependent signalling
Rudiger Woscholski (Imperial College London, United Kingdom)
12:20 - 14:00 Lunch

Session 2

 

Chair:
Marco Falasca (Barts and The London School of Medicine and Dentistry, United Kingdom)
Tuesday 6 May 2014
14:00 - 14:30
Receptor-mediated signals lead to inhibition or activation of Diacylglycerol kinase-alpha enzymatic activity, thus regulating diacylglcyerol- and phosphatidic acid-mediated signalling in a reciprocal manner
Andrea Graziani (University of Eastern Piedmont, Italy)
14:30 - 15:00
Placing molecules in a cellular context using light, electron and X-ray microscopy
Lucy Collinson (London Research Institute, United Kingdom)
15:00 - 16:30 Workshop
Application of advanced NMR spectroscopy, lipid mass spectrometry and quantitative fluorescence imaging and advanced electron microscopy in membrane morphology and function

Session 3

 

Chair:
Erick Dufourc (CNRS, University of Bordeaux, Bordeaux Polytechnic Institute, France)
Tuesday 6 May 2014
16:30 - 17:00
Specificity and Diversity in the PI 3-Kinase and Akt Signaling Pathway in Cancer
Alex Toker (Beth Israel Deaconess Medical Center, Harvard Medical School, U.S.A.)
17:00 - 17:30
Cell deformation and decision making during cell migration
Peter Friedl (Radboud University Nijmegen, The Netherlands)
17:30 - 17:45
Alterations of membrane curvature during influenza virus budding
Selected Oral Communication - Jeremy S. Rossman (University of Kent, Canterbury, United Kingdom)
17:45 - 18:00
Imatinib inhibits VEGF-independent angiogenesis by targeting NRP1-dependent ABL1 activation in endothelial cells
Selected Oral Communication – Claudio Raimondi (University College London, United Kingdom)
18:00 - 18:20 Coffee/Tea Break

18:20 - 18:50
Enzymatic control of transbilayer phospholipid distribution
Patrick Williamson (Amherst College, U.S.A.)
18:50 - 19:05
Dividing cells regulate their lipid composition
Selected Oral Communication - Eleonora Muro (King’s College London, United Kingdom)
19:05 - 19:35
OSBP: moving cholesterol using the metabolic energy of phosphoinositides
Bruno Antonny (Institut de Pharmacologie Moléculaire et Cellulaire Nice, France)
19:35 - 21:00 Dinner

21:00 - 22:30 Poster Session 1 - Odd numbered posters

Session 4

 

Chair:
Alex Toker (Beth Israel Deaconess Medical Center, Harvard Medical School, U.S.A.)
Wednesday 7 May 2014
09:00 - 09:30
Regulation of endosomal lipids
Jean Gruenberg (University of Geneva, Switzerland)
09:30 - 10:00
Lysophosphatidylinositol a novel link between ABC transporters and G protein-coupled receptors
Marco Falasca (Barts and The London School of Medicine and Dentistry, United Kingdom)
10:00 - 10:15
Allosteric regulation of PKB/Akt and PDK1 by intra- and intermolecular interactions
Selected Oral Communication - Veronique Calleja (Cancer Research UK, United Kingdom)
10:15 - 10:30
Role of calcium in membrane interactions by PI(4,5)P2 binding protein
Selected Oral Communication - Marina Monteiro (Instituto Superior Técnico, Universidade de Lisboa, Portugal)
10:30 - 10:50 Coffee/Tea Break

10:50 - 11:20
Membrane Dynamics by Nuclear Magnetic Resonance
Erick Dufourc (CNRS, University of Bordeaux, Bordeaux Polytechnic Institute, France)
11:20 - 11:35
Deciphering non alcoholic fatty-liver disease lipidomic fluxes
Selected Oral Communication - Ainara Cano (OWL metabolomics, Spain)
11:35 - 11:50
Quantitative analysis of the dynamics of Rab6 membrane carriers between the Golgi complex and endoplasmic reticulum in mammalian cells
Selected Oral Communication - Linda Heffernan (University College Dublin, Ireland)
11:50 - 12:05
Cytoplasmic dynamics of skeletal muscle α-actinin2 is regulated by PIP2
Selected Oral Communication - Andrea Ghisleni (King's College London, United Kingdom)
12:05 - 12:20
Impact of lipid composition on lysosomal membrane stability
Selected Oral Communication - Ana Maria Villamil (Linköping University, Sweden)
12:20 - 14:00 Lunch

14:00 - 14:30
Role of class II Phosphoinositide 3-kinases in prostate cancer
Tania Maffucci (Barts and The London School of Medicine and Dentistry, London, United Kingdom)
14:30 - 16:30 Poster Session II - Even numbered posters

Session 5

 

Chair:
Banafshe Larijani (IKERBASQUE, Basque Foundation for Science and Unidad de Biofísica (CSIC-UPV/EHU), University of the Basque Country,Spain)
Wednesday 7 May 2014
16:30 - 17:00
Strategies for Converting a Membrane Surface To a High-Resolution Lipid Signaling Screen
Vytas Bankaitis (Texas A&M Health Science Center, U.S.A.)
17:00 - 17:30
Interplay of protein and lipid components during the initiation of autophagy
Nicholas Ktistakis (The Babraham Institute , United Kingdom)
17:30 - 17:45
Osh4p is a carrier designed to use PI(4)P metabolism for transferring sterol against its gradient in cells
Selected Oral Communication - Joachim Moser von Filseck (IPMC - CNRS, France)
17:45 - 18:00
Quantifying Intracellular Intermolecular Interactions on an Image: Imaging Tools for the In-situ Description of PDK1 Regulation
Selected Oral Communication - Jose Requejo-Isidro (CSIC, Spain)
18:00 - 18:20 Coffee/Tea Break

18:20 - 18:50
Studies of the regulated assembly of SNARE complexes in adipocytes
Gwyn Gould (University of Glasgow, United Kingdom)
18:50 - 19:00
A novel DAG-dependent mechanism links PKCα and cyclin B1 regulating the G2/M progression of cell cycle
Selected Oral Communication - Alessandro Poli (University of Bologna, Italy)
19:00 - 19:35
Biophysical properties of ceramides, sphingosine and other simple sphingolipids
Félix Goñi (Unidad de Biofísica (CSIC-UPV/EHU), Spain)
19:35 - 21:00 Dinner

21:00 Social Event

Thursday 8 May 2014
09:00 - 09:15 Concluding Remarks and Departure

Buses depart at 09:45 for Chieti Scalo ProntoBus station

(for the express bus departing at 11:20)