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Past Events > Protein O-GlcNAcylation in Health and Disease

Protein O-GlcNAcylation in Health and Disease

8 July 2016

Charles Darwin House, London, UK



A Biochemical Society Hot Topic Event


Abstract deadline has been extended: 23 May 2016

Abstract submission now closed

 

Earlybird registration deadline has been extended: 23 May 2016

Registration now open.

 

While O-GlcNAc was discovered in the early 1980’s, more than half of the approximately 1,100 papers in the field have come out in the last 5 years. This is due in large part to the development of tools for interrogating this modification and the assignment of biological functions of the modification on specific nuclear and cytosolic proteins. In particular, significant recent advances in molecular understanding of the enzymes (O-GlcNAc transferase, O-GlcNAcase) involved has allowed for development of inhibitors and novel enrichment methods. Clear evidence for O-GlcNAc playing a role in a variety of fields has emerged in just the last 5 years. Perhaps most notably is the appreciation that the O-GlcNAc modification is involved at multiple levels in epigenetic regulation of gene expression. Beyond transcriptional regulation, evidence for O-GlcNAc serving as a nutrient sensor to modulate extracellular stimulated signal transduction has emerged recently. Further, abnormal glycosylation of nuclear and cytosolic proteins by O-GlcNAc has been implicated in a number of pathophysiological conditions include tauopathies, cardiovascular disease, cancer and diabetes. Very significant is the discovery in the last few months that mutations in OGT segregate with X-linked intellectual disability (XLID) and it is likely that the first insights into the mechanisms underpinning this will be first presented at this meeting.

The hot topic format is very suitable given the explosion in laboratories working on this modification that are not historically intracellular glycosylation laboratories. This is primarily due to laboratories chasing function and “stumbling” upon O-GlcNAc as a regulatory post-translational modification. This meeting would allow such groups to present (unpublished/incomplete) data and inform themselves with the latest techniques available to study this modification. It is anticipated that a significant number of new collaborations (academic:academic as well as academic:industrial) will emerge from this meeting. 

 

Oral communication slots are available at this meeting. All attendees, particularly researchers in the early stages of their career, are invited to submit a poster abstract for consideration as an oral communication.

 

Student Bursaries are available for this meeting.

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