A Biochemical Society Focused Meeting
The reversible phosphorylation of substrates by kinase and phosphatase enzymes is a fundamental currency used by all cells to process and interpret a diverse range of stimuli. The rewiring of phosphorylation networks underpins an array of pathological states, including cancer, chronic inflammation and metabolic disorders. Recent advances using a range of biochemical, cell biological and genetic approaches have served to underscore the key role played by spatial and temporal phosphatase activities in both physiological and pathophysiological settings. These include using novel imaging, proteomic and transgenic approaches to unveil previously cryptic regulatory roles. Many phosphatases previously considered 'undruggable' are also becoming increasingly viable and attractive therapeutic targets. We will therefore discuss current developments and methodology in resolving dynamic phosphatase function and the great potential of more widespread phosphatase-directed therapeutics at this meeting. The major themes include:
- The use of multiple experimental approaches to characterise the spatiotemporal signalling roles of phosphatases in health and disease.
- Overcoming challenges in target specificity with respect to small molecule inhibitors/drugs and their use as therapeutics or research tools.
- The likely role of phosphatase loss, mutation or inhibition in the remodelling of phosphorylation networks and the potential for combinatorial phosphatase/kinase inhibition in order to achieve sustained and effective treatment of pathological signalling.
Regulation of phosphatase localisation, substrate targeting and activity.
Therapeutic phosphatase targeting: challenges and future directions.
Phosphatase function in context: tissue-, cellular-, subcellular- and network- dependence.
Topics covered in this meeting will be published in Biochemical Society Transactions
Abstract deadline: 3 May 2016
Abstract Submission is now closed.
Earlybird registration deadline: 3 May 2016
Registration is now open.
Oral communication slots are available at this meeting. All attendees, particularly researchers in the early stages of their career, are invited to submit a poster abstract for consideration as an oral communication.
Student Bursaries and Full and Early Career Bursaries are available for this meeting.
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Invited Speakers Include:
Adrian Saurin (University of Dundee, United Kingdom)
Alexandra Newton (University of California at San Diego, U.S.A.)
Andy Clark (University of Birmingham, United Kingdom)
Anne Bertolotti (MRC Laboratory of Molecular Biology, United Kingdom)
Ari Elson (The Weizmann Institute of Science, Israel)
Benjamin Neel (NYU School of Medicine, U.S.A.)
John Scott (University of Washington, U.S.A.)
Jukka Westermarck (University of Turku, Finland)
Maja Kohn (EMBL Heidelberg)
Nicholas Tonks (Cold Spring Harbor Laboratory, U.S.A.)
Paola Vagnarelli (Brunel University London, United Kingdom)
Stephen Keyse (University of Dundee, United Kingdom)
View the scientific programme here.