A Biochemical Society Scientific Meeting
Abstract deadline: 17 April 2019
Earlybird registration deadline: 17 April 2019
Registration is now open!
Deubiquitylases (DUBs) are proteases that reverse ubiquitin modifications and thereby regulate protein turnover as well as the assembly of protein interaction networks, for example in signal transduction cascades. Protein ubiquitylation is used as a signal in most cellular pathways, from intracellular trafficking to transcription and DNA repair. This feat is made possible by the vast complexity of different types of ubiquitin modifications: ubiquitin can be added in monomeric form (mono-ubiquitylation) or alternatively multiple ubiquitins can be linked together to form 8 distinct poly-ubiquitin chains. Further complexity is added by the formation of mixed (or hybrid) chains and more recently identified post-translational modifications of ubiquitin itself. DUBs perform the daunting task of selectively recognising and countering specific ubiquitylation events at different sub-cellular localisations.
This conference is the second international meeting on DUBs and is unique in its focus on this class of enzymes. It will bring together researchers in this exciting field of research to discuss molecular mechanisms, cellular functions and physiological roles of DUBs. The recent development of highly specific inhibitors has led to a lot of interest in exploring these enzymes as therapeutic drug targets in a variety of disease settings ranging from infection and inflammation to cancer and neurodegeneration. Emerging new concepts in DUB regulation and translation will be a particular focus of this meeting.
This meeting will bring together international leaders in the field together with early stage researchers, in a setting and atmosphere aimed at fostering collegiality and collaboration. In addition to invited speakers, a number of short talks will be selected from submitted abstracts.
Conference Programme Coordinators:
Dr Sylvie Urbé, University of Liverpool
Dr Yogesh Kulathu, University of Dundee
Oral communication slots are available at this meeting. All attendees, particularly researchers in the early stages of their career, are invited to submit a poster abstract for consideration as an oral communication.
Student Bursaries are available for this meeting.
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