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The Biochemical Society provides an extensive range of events, including scientific conferences, outreach activities, medal lectures and policy and education events.  

 

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Future Events > BMP Signalling in Cancer II

BMP Signalling in Cancer II

1—3 April 2019

St Anne's College, Oxford, UK



A Biochemical Society Scientific Meeting

 

Abstract deadline: 31 January 2019

Click here to submit now

 

Earlybird registration deadline: 31 January 2019

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BMPs (body morphogenetic proteins) are members of the TGF-β family, which bind to and activate multiple receptor serine/threonine kinases. The BMP pathway regulates tissue development and regeneration. It has become clear that BMP signalling can be co-opted for both tumour initiation and promotion. These effects are strongly related to its role in regulating stem cells. Like TGF-β, BMP signalling can act as a tumour suppressor or tumour promoter, dependent on the microenvironmental context. For example, overexpression of the antagonist, Gremlin1 can promote colorectal cancer, while activating mutations in the BMP receptor kinase ALK2 drive a fatal paediatric glioma. 

 

The aim of this conference is to explore the mechanisms of BMP signal transduction and to discuss how genetic and epigenetic alterations result in aberrant signalling and how this leads to cancer. Microenvironmental control of cancer cell function is a research area of intense interest and as a key mesenchymal-epithelial signalling pathway, BMP signalling is emerging as a key therapeutic target. We aim to discuss in detail how to manipulate the pathway, both positively and negatively with small molecules or biologics.

 

Topics in this meeting may be invited to submit to our journal, Biochemical Society Transactions, or other publication published by Portland Press, the wholly-owned trading subsidiary of the Biochemical Society.

 

Oral communication slots are available at this meeting. All attendees, particularly researchers in the early stages of their career, are invited to submit a poster abstract for consideration as an oral communication.

 

Student Bursaries are available for this meeting.

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