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Sponsored by:

Deubiquitinases - from structure to physiology

26—28 June 2017

St Hugh's College, Oxford



Organizers:
Michael Clague (University of Liverpool, United Kingdom)
David Komander (MRC Laboratory of Molecular Biology, United Kingdom)

Session 1: Structure and mechanism of DUBs

Monday 26 June 2017
13:00 - 13:45 Registration and Lunch

13:45 - 14:00 Welcome and Introduction

14:00 - 14:35
Titia Sixma (Netherlands Cancer Institute, Netherlands)
14:35 - 14:55
Mechanism and Regulation of the Lys6-selective Deubiquitinase USP30
Selected Oral Communication - Malte Gersch (MRC LMB, Cambridge, United Kingdom)
14:55 - 15:30
Elton Zeqiraj (University of Leeds, United Kingdom)
15:30 - 16:00 Refreshment Break

16:00 - 16:30
EMBO YIP Lecture: Yogesh Kulathu (University of Dundee, United Kingdom)
16:30 - 16:50
A novel CA-clan DUB with unusual properties.
Selected Oral Communication - Thomas Hermanns (University of Cologne)
16:50 - 17:20
Aude Echalier (University of Leicester, United Kingdom)
17:20 - 18:00
Keynote Speaker - Daniel Finley (Harvard Medical School, U.S.A.)
18:00 - 19:00 Poster Session 1

Session 2: Cell Biology of Deubiquitylases

Tuesday 27 June 2017
09:00 - 09:35
Alan D'Andrea (Harvard, U.S.A.)
09:35 - 10:10
Sylvie Urbé (University of Liverpool, United Kingdom)
10:10 - 10:30
Understanding and targeting USP8 function in endocytosis
Selected Oral Communication - Marie-Odile Fauvarque (Biosciences and Biotechnology Institute of Grenoble, France)
10:30 - 11:00 Refreshment Break

11:00 - 11:35
EMBO YIP Lecture: Anna Sablina (University of Leuven (KU Leuven), Belgium)
11:35 - 11:55
Function of AMSH DUBs in Arabidopsis thaliana
Selected Oral Communication - Karin Vogel (University Konstanz)
11:55 - 12:15
How pathogenic bacteria subvert host ubiquitin signaling
Selected Oral Communication - Jonathan Pruneda (MRC Laboratory of Molecular Biology, United Kingdom)
12:15 - 12:50
Judy Coulson (University of Liverpool, United Kingdom)
13:00 - 14:00 Lunch

Session 3: Deubiquitylases in disease

Tuesday 27 June 2017
14:00 - 14:35
Mads Gyrd-Hansen (University of Oxford, United Kingdom)
14:35 - 15:10
Martin Eilers (University of Würzburg, Germany)
15:10 - 15:30
Regulation of the tumor suppressor complex BAP1-ASXL2 by ubiquitination
Selected Oral Communication - El Bachir Affar (Centre de Recherche, Hospital Maisonneuve-Rosemont)
15:30 - 16:00 Refreshment Break

16:00 - 16:35
Klaus-Peter Knobeloch (Freiburg, Germany)
16:35 - 16:55
The ubiquitin-specific protease USP5 is required for proteasome-dependent protein degradation in the myocardium
Selected Oral Communication - Mareike Poetsch (Max-Planck-Institute for Heart and Lung Research)
16:55 - 17:15
Ubiquitin dependent regulation of CYLD
Selected Oral Communication - Tencho Tenev (ICR)
17:15 - 17:35
Ubiqutin dependent unfoldase p97 and deubiquitinating enzyme Ataxin 3 regulate DNA damage response after ionizing radiation
Selected Oral Communication - Kristijan Ramadan (1Cancer Research UK/Medical Research Council Oxford Institute for Radiation Oncology)
17:35 - 18:30 Poster Session 2

19:30 Conference Dinner

Session 4: Therapeutic targeting of DUBs

Wednesday 28 June 2017
09:00 - 09:40
Ingrid Wertz (Genentech, United Kingdom)
09:40 - 10:15
Matthias Trost (University of Newcastle, United Kingdom)
10:15 - 10:30
Molecular basis of USP7 inhibition by selective small molecule inhibitors
Selected Oral Communication - Andrew Turnbull (Cancer Research Technology Ltd)
10:30 - 11:00 Refreshment Break

11:00 - 11:20
Usp8 modifies α-synuclein toxicity in Parkinson's disease models by negatively regulating its lysosomal degradation.
Selected Oral Communication - George Tofaris (University of Oxford, United Kingdom)
11:20 - 11:40
Deubiquitinase Activity Profiling in Breast Cancer
Selected Oral Communication - Sijia Liu (Leiden University Medical Center (LUMC), Netherlands)
11:40 - 12:15
Huib Ovaa (Leiden University Medical Center (LUMC), Netherlands Sponsored by Cancer Research Technology)
12:15 Meeting Close and Packed Lunch