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The Pleiotropic Nuclear Envelope

22—25 August 2017

John McIntyre Conference Centre, University of Edinburgh, UK



Organizers:
Sue Shackleton (University of Leicester, United Kingdom)
Eric Schirmer (University of Edinburgh, United Kingdom)
Edgar Gomes (University of Lisbon , Portugal)
Tuesday 22 August 2017
16:30 Registration

17:00 'Welcome' drinks reception

18:00 - 19:00
Susan Gasser (Friedrich Miescher Institute, Switzerland)

Session 1: New Directions in Nuclear Envelopathies

Wednesday 23 August 2017
09:00 - 09:30
Therapies for nuclear envelope-linked dystrophies
Gisele Bonne (UM76 - UPMC Univ. Paris 6 / U974 - Inserm / UMR7215 - CNRS, France)
09:30 - 10:00
Nesprins: roles in nuclear envelope organisation, myogensis and disease
Qiuping Zhang (King's College London, United Kingdom)
10:00 - 10:15
Myotonic Dystrophy: links to the nuclear envelope
Selected Oral Communication - Peter Meinke (Friedrich-Baur-Institut, Germany)
10:15 - 10:30
Nuclear defects in patients with inherited diseases of the skeletal muscle contractile filaments
Selected Oral Communication - Jacob Ross (Kings College London, UK)
10:30 - 11:00 Refreshment Break

11:00 - 11:15
Deep coverage microscopy reveals aberrant nuclear dynamics in laminopathy model cells
Selected Oral Communication - Winnok De Vos (Antwerp University, Belgium)
11:15 - 11:30
POPDC3, a member of the Popeye domain containing gene family, is associated with a centronuclear myopathy-like phenotype
Selected Oral Communication - Thomas Brand (Imperial College London, UK)
11:30 - 11:55
CRISPR mouse models
Matt Wheeler (Cyagen)
11:55 - 12:20 Flash Poster Presentations

12:20 - 14:30 Lunch and Poster Session 1

Session 2: Dynamic Nucleo-cytoskeletal Interactions and mechanotransduction

Wednesday 23 August 2017
14:30 - 14:55
Squeezing the nucleus to the periphery of skeletal myofibers
Edgar Gomes (University of Lisbon, Portugal)
14:55 - 15:15
LINCing myonuclei to the microtubule network and its role in muscular dystrophy
Sue Shackleton (University of Leicester, UK)
15:15 - 15:30
Emery-Dreifuss Muscular Dystrophy-linked genes and Centronuclear myopathy-linked genes regulate myonuclear movement by distinct mechanisms
Selected Oral Communication - Eric Folker (Boston College, USA)
15:30 - 15:45
Nuclear decoupling and chaperones protect cell homeostasis during mechanical loading
Selected Oral Communication - Hamish Gilbert (University of Manchester, UK)
15:45 - 16:00
Multiple isoforms of nesprin1 are integral components of ciliary rootlets
Selected Oral Communication - Didier Hodzic (Washington University, USA)
16:00 - 16:30 Refreshment Break

Session 3: Genome Regulation from the Nuclear Envelope

Wednesday 23 August 2017
16:30 - 17:00
Gene positioning at the nuclear periphery
Wendy Bickmore (IGMM, United Kingdom)
17:00 - 17:30
A-type nuclear lamins and regulation of spatial genome conformation
Philippe Collas (University of Oslo, Norway)
17:30 - 17:45
Imaging chromatin dynamics reveals a novel mechanism for nuclear organisation after cell division
Selected Oral Communication - Alice Sherrard (University of Bristol, UK)
17:45 - 18:00
Epigenetic maintenance of genome architecture by nuclear pore proteins
Selected Oral Communication - Maya Capelson (University of Pennsylvania, Philadelphia, USA)
18:00 - 18:15
Concomitant nuclear localization of gene loci and functional distribution of their encoded proteins
Selected Oral Communication - Steven Kosak (Northwestern University, Chicago, USA)

Session 4: New Signalling Pathways and Mechanisms

Thursday 24 August 2017
09:00 - 09:30
ERK signalling in lamin-associated cardiomyopathy
Howard Worman (Columbia University, U.S.A.)
09:30 - 10:00
RepoMan regulation of nuclear membrane proteins
Paola Vagnarelli (Brunel University London, United Kingdom)
10:00 - 10:15
super resolution approaches
TBC (Zeiss)
10:15 - 10:45 Refreshment Break

10:45 - 11:00
Distinct nuclear transport pathways for inner nuclear membrane proteins revealed by super-resolution microscopy
Selected Oral Communication - Weidong Yang (Temple University, Philadelphia, USA)
11:00 - 11:30
Translocation through the peripheral NPC channels
Ulrike Kutay (ETH Zurich, Switzerland)
11:30 - 12:00 Flash Poster Presentations

12:00 - 14:15 Lunch and Poster Session 2

Session 5: Detailed Structure of the Lamina and Membrane Complexes

Thursday 24 August 2017
14:15 - 14:45
Herpesvirus nuclear egress – the prototypic vesicular nucleo-cytoplasmic transport
Thomas Mettenleiter (Friedrich-Loeffler-Institut, Germany)
14:45 - 15:00
Bead-induced nuclear envelope assembly in the living cell
Selected Oral Communication - Tokuko Haraguchi (Advanced ICT Research Institute Kobe, NICT, Japan)
15:00 - 15:30
EMBO Young investigator Lecture
Protein turnover at the nuclear envelope
Pedro Carvalho (Centre for Genomic Regulation, Spain)
15:30 - 16:00 Refreshment Break

Session 6: Progeria Sponsored by the Society of Biologists

Thursday 24 August 2017
16:00 - 16:30
Signaling changes in Progeria
Maria Eriksson (Karolinska Institutet , Sweden)
16:30 - 16:45
Are molecular defects identified by a prelamin A mediated cardiomyopathy model recapitulated in human cardiomyopathy?
Selected Oral Communication - Daniel Brayson (King's College London, London, UK)
16:45 - 17:00
Transcription factor Prep1 is a novel regulator of nuclear structure and stablity
Selected Oral Communication - Divya Purushothaman (IFOM, Milano, Italy)
17:00 - 17:30
Keynote Progeria: A paradigm for modern biomedical research
Tom Misteli (National Cancer Institute, U.S.A.)
19:00 Conference Dinner: John McIntyre Conference Centre

Session 7: Nuclear Membrane Biosynthesis and Dynamics

Friday 25 August 2017
09:00 - 09:30
FFS quantification of NET complexes
GW Gant Luxton (University of Minnesota, U.S.A.)
09:30 - 10:00
CLMS to determine lamin structure
Eric Schrimer (Edinburgh University, UK)
10:00 - 10:15
Using C. elegans to dissect lamin-mediated nuclear envelope repair mechanisms in vivo
Selected Oral Communication - Shirin Bahmanyar (Yale University, USA)
10:15 - 10:30
A three-dimensional view of the interface between nuclear envelope and chromatin
Selected Oral Communication - Camille Samson (CEA Saclay, Gif-Sur-Yvette, France)
10:30 - 11:00 Refreshment Break

Session 8: Potpourri of Nuclear Envelope Functions

Friday 25 August 2017
11:00 - 11:30
NanoSIMS shows de novo lipid synthesis in the nucleus
David Vaux (Oxford University, United Kingdom)
11:30 - 11:45
Torsins on the inner nuclear membrane provide evolutionarily conserved control over cellular lipid metabolism
Selected Oral Communication - Rose Goodchild (VIB, Belgium)
11:45 - 12:00
ESCRTs at the nuclear envelope: for better or worse
Selected Oral Communication - Coen Campsteijn (University of Oslo, Oslo, Norway)
12:00 - 12:30
ESCRTs in nuclear envelope dynamics
Jeremy Carlton (King's College London, United Kingdom)
12:30 Meeting Close