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Non-Coding RNA: Recent Insights into the Mechanisms of Action

22—23 June 2017

Royal College of Surgeons of Edinburgh, Edinburgh, UK



Organizers:
Andrea Caporali (University of Edinburgh, UK)
Andrew Baker (University of Edinburgh, UK)
Donal O'Carroll (University of Edinburgh, UK)
Javier Caceres (University of Edinburgh, UK)
Thursday 22 June 2017
12:00 - 13:00 Registration

Session 1: ncRNA and epigenetic regulation

Thursday 22 June 2017
13:00 - 13:30
GxE in worm and fish
Eric Miska (Gurdon Institute, University of Cambridge, United Kingdom)
13:30 - 14:00
Expression and function of lncRNAs during oocyte-to-embryo transition
Petr Svoboda (IMG, Czech Republic)
14:00 - 14:30
Selected Oral Communication- Fitness landscape of a yeast snoRNA
Grzegorz Kudla (University of Edinburgh, UK)
14:30 - 15:00
Selected Oral Communication- Control of cell division by long noncoding RNAs
Lovorka Stojic (CRUK Cambridge Institute, UK)
15:00 - 15:30 Refreshment Break

Session 2: RNA decay

Thursday 22 June 2017
15:30 - 16:00
Tudor-SN-mediated endonucleolytic decay of human-cell microRNAs promotes G1/S phase transition
Lynne Maquat (University of Rochester, U.S.A.)
16:00 - 16:30
Uridylation-mediated cytoplasmic RNA quality control in mammalian cells
Stepanka Vanacova (CEITEC, Czech Republic)
16:30 - 17:00
Selected Oral Communication- Coordination of non-coding and messenger RNA lifecycles is essential for mammalian immune responses
Dimitris Lagos (University of York, UK)
17:00 - 17:30
Selected Oral Communication- TRBP and PACT pose stoichiometric questions for Dicer complex assembly
Michael Plevin (University of York, UK)
17:30 - 19:30 Drinks Reception and Informal Poster Viewing

Session 3: ncRNA and gene regulation

Friday 23 June 2017
09:00 - 09:30
What do mouse piRNAs do?
Phillip Zamore (University of Massachusetts Medical School, U.S.A.)
09:30 - 10:00
TBC
Irene Bozzoni (Sapienza University of Rome, Italy)
10:00 - 10:30
Selected Oral Communication- Interplay between a transcriptional coactivator – Psip1 and a lncRNA Hottip in regulation of Hox genes
Pradeepa Madapura (University of Essex, UK)
10:30 - 11:00
Selected Oral Communication- A cryptic RNA binding domain explains selectivity in Syncrip-mediated exosomal loading of miRNAs
Andres Ramos (University College London, UK)
11:00 - 11:30 Refreshment Break

Session 4: ncRNA in stem cells

Friday 23 June 2017
11:30 - 12:00
ncRNA biogenesis and quality control – links to disease
Richard Gregory (Harvard Medical School, U.S.A.)
12:00 - 12:30
Modes of action of long noncoding RNAs in mammalian cells
Igor Ulitsky (Weizmann Institute of Science, Israel)
12:30 - 13:00
RNA silencing using Antisense LNATM GapmeRs
Johnathan Lai (Exiqon, Denmark)
13:00 - 13:30
Selected Oral Communication- LIMD1 family proteins dictate a hierarchy of human Argonaute function
Kunal Shah (Queen Mary University London, UK)
13:30 - 14:30 Meet-the-expert lunch

Session 5: ncRNA in development and differentiation

Friday 23 June 2017
14:30 - 15:00
Function of cytosine-5 methyation in non-coding RNA
Michaela Frye (University of Cambridge, United Kingdom)
15:00 - 15:30
Dissecting the In Vivo Functions & Mechanisms of Action of lncRNAs
Alena Shkumatava (Institute Curie, France)
15:30 - 16:00
Selected Oral Communication -Long non-coding RNA SMILR interacts with Staufen1 regulatory protein and modulates cell cycle and histone associated mRNA networks.
Margaret Ballantyne (University of Edinburgh, UK)
16:00 - 16:30
Selected Oral Communication- Functional high-throughput screening identifies microRNA-26b as pro-survival and angiogeneic factor for endothelial cells
David Mellis (University of Edinburgh, UK)
16:30 - 17:00 Closing Remarks