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Non-Coding RNA: Recent Insights into the Mechanisms of Action

22—23 June 2017

Royal College of Surgeons of Edinburgh, Edinburgh, UK

Andrea Caporali (University of Edinburgh, UK)
Andrew Baker (University of Edinburgh, UK)
Donal O'Carroll (University of Edinburgh, UK)
Javier Caceres (University of Edinburgh, UK)
Thursday 22 June 2017
12:00 - 13:00 Registration

Session 1: ncRNA and epigenetic regulation

Thursday 22 June 2017
13:00 - 13:30
GxE in worm and fish
Eric Miska (Gurdon Institute, University of Cambridge, United Kingdom)
13:30 - 14:00
Expression and function of lncRNAs during oocyte-to-embryo transition
Petr Svoboda (IMG, Czech Republic)
14:00 - 14:30
Selected Oral Communication- Fitness landscape of a yeast snoRNA
Grzegorz Kudla (University of Edinburgh, UK)
14:30 - 15:00
Selected Oral Communication- Control of cell division by long noncoding RNAs
Lovorka Stojic (CRUK Cambridge Institute, UK)
15:00 - 15:30 Refreshment Break

Session 2: RNA decay

Thursday 22 June 2017
15:30 - 16:00
Tudor-SN-mediated endonucleolytic decay of human-cell microRNAs promotes G1/S phase transition
Lynne Maquat (University of Rochester, U.S.A.)
16:00 - 16:30
Uridylation-mediated cytoplasmic RNA quality control in mammalian cells
Stepanka Vanacova (CEITEC, Czech Republic)
16:30 - 17:00
Selected Oral Communication- Coordination of non-coding and messenger RNA lifecycles is essential for mammalian immune responses
Dimitris Lagos (University of York, UK)
17:00 - 17:30
Selected Oral Communication- TRBP and PACT pose stoichiometric questions for Dicer complex assembly
Michael Plevin (University of York, UK)
17:30 - 19:30 Drinks Reception and Informal Poster Viewing

Session 3: ncRNA and gene regulation

Friday 23 June 2017
09:00 - 09:30
What do mouse piRNAs do?
Phillip Zamore (University of Massachusetts Medical School, U.S.A.)
09:30 - 10:00
Irene Bozzoni (Sapienza University of Rome, Italy)
10:00 - 10:30
Selected Oral Communication- Interplay between a transcriptional coactivator – Psip1 and a lncRNA Hottip in regulation of Hox genes
Pradeepa Madapura (University of Essex, UK)
10:30 - 11:00
Selected Oral Communication- A cryptic RNA binding domain explains selectivity in Syncrip-mediated exosomal loading of miRNAs
Andres Ramos (University College London, UK)
11:00 - 11:30 Refreshment Break

Session 4: ncRNA in stem cells

Friday 23 June 2017
11:30 - 12:00
ncRNA biogenesis and quality control – links to disease
Richard Gregory (Harvard Medical School, U.S.A.)
12:00 - 12:30
Modes of action of long noncoding RNAs in mammalian cells
Igor Ulitsky (Weizmann Institute of Science, Israel)
12:30 - 13:00
RNA silencing using Antisense LNATM GapmeRs
Johnathan Lai (Exiqon, Denmark)
13:00 - 13:30
Selected Oral Communication- LIMD1 family proteins dictate a hierarchy of human Argonaute function
Kunal Shah (Queen Mary University London, UK)
13:30 - 14:30 Meet-the-expert lunch

Session 5: ncRNA in development and differentiation

Friday 23 June 2017
14:30 - 15:00
Function of cytosine-5 methyation in non-coding RNA
Michaela Frye (University of Cambridge, United Kingdom)
15:00 - 15:30
Dissecting the In Vivo Functions & Mechanisms of Action of lncRNAs
Alena Shkumatava (Institute Curie, France)
15:30 - 16:00
Selected Oral Communication -Long non-coding RNA SMILR interacts with Staufen1 regulatory protein and modulates cell cycle and histone associated mRNA networks.
Margaret Ballantyne (University of Edinburgh, UK)
16:00 - 16:30
Selected Oral Communication- Functional high-throughput screening identifies microRNA-26b as pro-survival and angiogeneic factor for endothelial cells
David Mellis (University of Edinburgh, UK)
16:30 - 17:00 Closing Remarks