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Glycobiology in Infectious Disease

4—5 September 2017

Keele University, UK



Organizers:
Sarah Berry (Keele University, United Kingdom)
Helen Price (Keele University, United Kingdom)
Mark Skidmore (Keele University, United Kingdom)
Marissa Maciej-Hulme (Radboud University Nijmegen Medical Centre, Netherlands)
Monday 4 September 2017
09:30 - 10:45 Registration

10:45 - 11:00 Welcome and Introduction

Glycobiological Tools and Technologies I

Monday 4 September 2017
11:00 - 11:45
Discovery of a new carbohydrate-binding megavirus associated with toxin release from harmful algal blooms
Rob Field (John Innes Centre, United Kingdom)
11:45 - 12:05
Development and applications of lectins as biological tools in diagnosis of diseases.
Selected Oral Communication- Navkiran Kaur ((Amity Institute of Biotechnology, India)
12:05 - 12:25
Mimetic sugar nucleotides to probe a strategic bacterial dehydrogenase enzyme
Selected Oral Communication- Gavin J Miller (Keele University, UK)
12:25 - 13:30 Lunch/ Poster Session 1

Pathogenesis and Disease I

Monday 4 September 2017
13:30 - 14:15
Alvaro Acosta-Serrano (Liverpool School of Tropical Medicine, United Kingdom)
14:15 - 14:35
Glycoproteomics of the Clostridium difficile S-layer.
Selected Oral Communication- Laura Bouché (Imperial College London, UK)
14:35 - 14:55
Nuclear Magnetic Resonance and Molecular Dynamic Simulation of the interaction between recognition protein of the Influenza A virus and glycan cell surface receptors.
Selected Oral Communication- Stefano Elli (Ronzoni Institute, Italy)
14:55 - 15:40
Pharmaceutical heparin improves survival of human neural progenitor cells infected with ZIKA virus
Eliza Vicenzi (San Raffaele Scientific Institute, Italy)
15:40 - 16:15 Tea/ Coffee Break

Intervention, Targets and Strategies I

Monday 4 September 2017
16:15 - 17:00
The HIV glycan shield as a target for broadly neutralizing antibodies
Katie Doores (Kings College London, United Kingdom)
17:00 - 17:20
S. pyogenes Group A Carbohydrate: Investigating and targeting a virulence factor biosynthesis pathway.
Selected Oral Communication- Helge Dorfmueller (University of Dundee, UK)
17:20 - 17:40
Endo-α-1,2-mannosidase inhibition as a potential antiviral therapy method.
Selected Oral Communication- Lukasz F. Sobala (University of York, UK)
17:40 - 18:40 Poster Session 2

19:15 - 20:00 Research in Three Minutes” and Drinks Reception

20:00 Conference Dinner

Intervention, Targets and Strategies II

Tuesday 5 September 2017
09:00 - 09:45
Glycobiology of syndecan-1 in bacterial infections
Pyong Park (Harvard University, U.S.A.)
09:45 - 10:05
Exploiting the human anti-α-gal response to cutaneous leishmaniasis for diagnosis.
Selected Oral Communication- Victoria M. Austin (Liverpool School of Tropical Medicine, UK)
10:05 - 10:25
Novel covalent probes for a bacterial glycosyltransferase: discovery and applications.
Selected Oral Communication- Gerd K. Wagner (King’s College London, UK)
10:25 - 10:45
Analysis of heparan sulphate in the infection of host macrophages by Leishmania parasites.
Selected Oral Communication- Marissa Maciej-Hulme (Radboudumc, Netherlands)
10:45 - 11:10 Tea/ Coffee Break

Glycobiological Tools and Technologies II

Tuesday 5 September 2017
11:10 - 11:30
The unique polysialic acid binding of human adenovirus 52 – glycan microarray, structural insights and future implications
Selected Oral Communication- Yan Liu (Imperial College London, UK)
11:30 - 11:50
Development of bio-orthogonal fluorescent tags for carbohydrate analysis and functional assays.
Selected Oral Communication- Katarzyna Brzezicka (The Open University, UK)
11:50 - 12:10
Glycosylation of Trypanosome antigens in recombinant systems.
Selected Oral Communication- Barrie Rooney (University of Kent, UK)
12:10 - 12:55
Tim Rudd (National Institute for Biological Standards and Control, United Kingdom)
12:55 - 14:00 Lunch

Intervention, Targets and Strategies II

Tuesday 5 September 2017
14:00 - 14:20
TB Drug Targets in Mycobacterium tuberculosis α-Glucan Metabolism.
Selected Oral Communication- Sibyl F. Batey (John Innes Society, UK)
14:20 - 14:40
Pinpointing epithelial glycan receptors for rotaviruses by O-glycome beam search array approach
Selected Oral Communication- Zhen Li (Imperial College London, UK)
14:40 - 15:25
Michael Ferguson (University of Dundee, United Kingdom)
15:25 - 15:45 Closing Remarks and Depart