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7th European Conference on Tetraspanins

7—9 September 2016

University of Sheffield, UK

Peter Monk (Sheffield University Medical School, United Kingdom)
Lynda Partridge (University of Sheffield, United Kingdom)
Wednesday 7 September 2016
08:30 - 09:00 Registration and Refreshments

09:00 - 09:10 Welcome and Introduction
Pete Monk (Sheffield University Medical School, UK) & Lynda Partridge (University of Sheffield, UK)

Session 1: Cancer and Cell Regulation

Wednesday 7 September 2016
09:10 - 09:40
B-cell survival is controlled by tetraspanin CD37; implications for lymphomagenesis
Annemiek van Spriel (Radboud University, Netherlands)
09:40 - 10:10
Tetraspanins in cancer: "old" news and new ideas.
Fedor Berditchevski (University of Birmingham, United Kingdom)
10:10 - 10:40
Positive and Negative Regulation of TGFbeta-dependent Events in Melanoma
Martin Hemler (Dana-Farber Cancer Institute, U.S.A.)
10:40 - 11:20 Refreshment Break

11:20 - 11:50
Bone/Osteoclast Phenotype of CD82 KO Mice
Cindy Miranti (Van Andel Research Institute, U.S.A.)
11:50 - 12:10
Metastatic cellular functions regulated by TM4SF5 (transmembrane 4 L six family member 5)
Selected Oral Communication - Jung Weon Lee (College of Pharmacy, Seoul National University)
12:10 - 12:30
Tetraspanins in control of epithelial-to-mesenchymal transition
Selected Oral Communication - Henryk J Korza (Stockholm University)
12:30 - 12:50
Tspan5: in vitro and in vivo studies
Julien Saint-Pol (Inserm, France)
12:50 - 14:00 Lunch and Informal Poster Viewing

14:00 - 14:30
Tspan8ko and CD151ko mice: joint features and complimentarities
Margot Zoller (University of Heidelberg, Germany)
14:30 - 15:00
CD81 as a tumour target
Shoshana Levy (Stanford University, U.S.A.)
15:00 - 15:20
The role of Tspan6 in colorectal cancer
Selected Oral Communication - Regina Andrijes (University of Birmingham)
15:20 - 15:40
Tspan15 is a new stemness-related marker in hepatocellular carcinoma
Selected Oral Communication - Francois Le Naour (Inserm)
15:40 - 16:10 Refreshment Break

16:10 - 16:40
Regulation of the molecular scissor ADAM10 by TspanC8 tetraspanins
Michael Tomlinson (University of Birmingham, United Kingdom)
16:50 - 17:10
Regulation of adhesion signaling in osteoclasts by tetraspanin CD82
Selected Oral Communication - Alexis Bergsma (Van Andel Institute)
17:10 - 17:30
Tetraspanins CD9 and CD81 coordinate a JAM-A-regulated negative feedback loop to balance c-Src activity in tumor cells
Selected Oral Communication - Klaus Ebnet (University Muenster)
17:30 - 18:00 Flash talks from posters

18:00 - 19:30 Poster Session and Buffet Dinner

Session 2: Infection and Immunity

Thursday 8 September 2016
09:00 - 09:30
Tetraspanin CD82 regulates hematopoietic stem cell fitness through the modulation of niche interactions
Jennifer Gilette (University of New Mexico, U.S.A.)
09:30 - 10:00
Tetraspanins are key players in the inflammatory adhesion cascade
Mark Wright (Monash University, Australia)
10:00 - 10:30
TSPAN7, a new effector of actin nucleation required for dendritic cell-mediated transfer of HIV-1 to T cells
Mikkel Menager (New York University School of Medicine, U.S.A.)
10:30 - 11:00 Refreshment Break

11:00 - 11:30
CD82 is required for TLR9 trafficking
Jay Vyas (Harvard Medical School, U.S.A.)
11:30 - 11:50
Tetraspanin Tspan18 controls endothelial Ca2+ signals in hemostasis and inflammation
Selected Oral Communication - Peter Noy (University of Birmingham)
11:50 - 12:10
TspanC8 tetraspanins differentially regulate the trafficking of the metalloprotease ADAM10
Selected Oral Communication - Etienne Eschenbrenner (Inserm)
12:10 - 12:30
The CD63-syntenin-1 complex controls post-endocytic trafficking of oncogenic human papillomaviruses
Selected Oral Communication - Laura Fast (University of Mainz)
12:30 - 14:00 Lunch and Informal Poster Viewing

14:00 - 14:30
Tetraspanins in infections by Human Papilloma and Cytomegaloviruses
Luise Florin (University of Mainz, Germany)
14:30 - 14:45
Tetraspanin-7 as an autoantigen in Type 1 diabetes
Selected Oral Communication - Michael Christie (University of Lincoln)
14:45 - 15:00
Cellular and subcellular localisation of the type 1 diabetes autoantigen tetraspanin-7 in neuroendocrine cells
Selected Oral Communication - Kerry McLaughlin (University of Oxford)
15:00 - 15:20
Tetraspanin CD37 regulates C-type lectin receptor 2 (CLEC-2) function on dendritic cells
Selected Oral Communication - Charlotte de Winde (Radboud Institute for Molecular Life Sciences)
15:20 - 15:40
A role for CD151 in phagocytosis of Staphylococcus aureus by human neutrophils
Selected Oral Communication - Andreea Ciuntu (University of Sheffield)
15:40 - 16:10 Refreshment Break

Session 3: Tetraspanin and Membrane Structure

Thursday 8 September 2016
16:10 - 16:40
How endothelial membrane nano-architecture helps to capture leukocytes
Christoph Riethmuller (University of Munster, Germany)
16:40 - 17:00
From single CD81 molecules to tetraspanin enriched microdomains
Selected Oral Communication - Thorsten Lang (Life and Medical Sciences (LIMES) Institute)
17:00 - 17:20
Visualization of PKC recruitment to CD53 microdomains in living B cells
Selected Oral Communication - Vera-Marie Dunlock (Radboud Institute for Molecular Life Sciences)
17:20 - 17:50
New tetraspanin EC2 structure
Steve Blacklow (Harvard Medical School)
18:15 - 19:30 Open access to Museum of Kelham Island
Coach pick-up from Diamond Building at 6pm

19:30 Conference Dinner
Kelham Island

Session 4: Tetraspanins and Exosomes

Friday 9 September 2016
09:30 - 10:00
Dendritic cell derived exosomes for cancer therapy
Susanne Gabrielsson (Karolinska Institutet, Sweden)
10:00 - 10:20
Role of tetraspanins in the biogenesis of exosomes
Selected Oral Communication - Carla Mazzeo (CBM-SO/UAM)
10:20 - 10:40
Characterisation of human tetraspanin Tspan2: development of novel mAbs and the role of Tspan2 in cell adhesion
Selected Oral Communication - Ibrahim Yaseen (University of Sheffield)
10:40 - 11:10 Refreshment Break

11:10 - 11:30
Cancer stem cell markers and exosomes
Selected Oral Communication - Ulrike Erb (University Hospital of Surgery)
11:30 - 12:00
Exosome Methodologies
Maria Yanez Mo (University Hospital of La Princesa)
12:00 - 13:00 Lunch and Exosome Poster Viewing

13:00 - 16:00 Hands-on demonstrations related to exosome characterization