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Inflammatory diseases - mechanisms and clinical perspectives

3—4 November 2016

Maynooth University, Ireland



Sinead Miggin (Maynooth University, Ireland)
Marian Brennan (RCSI, Ireland)
Anne Parle-McDermott (Dublin City University, Ireland)
Eoin Fleming (University College Cork, Ireland)
Thursday 3 November 2016
09:00 - 09:30 Registration - Iontas Building, North Campus

09:30 - 09:45 Opening Address
Professor Philip Nolan, President of Maynooth University

Session 1: Microbiome and inflammation

Thursday 3 November 2016
09:45 - 10:15
Microbiome alterations in a Pellino 3 knockout mouse model
Fiona Walsh (Maynooth University, Ireland)
10:15 - 10:45
Novel regulators of barrier function, microbial interactions and intestinal heath
Sinead Corr (Trinity College Dublin, Ireland)
10:45 - 11:05
The brain ↔ gut axis in Parkinson’s disease (PD): Altered gut pathophysiology and increased gut inflammation in the rAAV-α-synuclein rat model of PD
Selected Oral Communication - Sarah M O'Donovan (University College Cork, Cork, Ireland)
11:05 - 11:25
The role of glycopeptides in chronic helminth infection
Selected Oral Communication - Arlene Glasgow (Dublin City University, Dublin, Ireland)
11:25 - 11:45
Mining Marine Sources for Functional Ingredients with Immunomodulatory Activities
Selected Oral Communication - Kim Connick (DCU, Dublin, Ireland)
11:45 - 12:05
Elucidating the effect of westernized diet on neuro-immune responses in intestinal inflammation
Selected Oral Communication - Silvia Melgar (UCC, Cork, Ireland)
12:00 - 13:30 Lunch and Poster Session 1

Session 2: Molecular mechanisms of Disease

Thursday 3 November 2016
13:30 - 14:00
Pre-clinical development of an anti-TLR2 antibody as a novel oncology therapeutic
Peter McGuirk (Opsona Therapeutics, Ireland)
14:00 - 14:30
New ubiquitination pathways in inflammatory diseases
Paul Moynagh (Maynooth University, Ireland)
14:30 - 15:00
Pharmaceutical induction of the NF-κB modulator A20
Bettina Schock (Queen's University Belfast, United Kingdom)
15:00 - 15:10
Inflammatory-environment interactions as an approach to modelling Parkinson’s disease
Selected Oral Communication - Kiah McCabe (National University of Ireland, Galway, Galway, Ireland)
15:10 - 15:20
Serum haptoglobin as a marker of sterile inflammation in dystrophinopathy
Selected Oral Communication - Sandra Murphy (Maynooth University, Ireland)
15:20 - 15:30
Mitochondrial regulation of age-related inflammation and cardiomyopathy
Selected Oral Communication - Fiachra Humphries (Maynooth University, Ireland)
15:30 - 16:00 Refreshment Break

Session 3: Industrial Outreach and pharmaceuticals

Thursday 3 November 2016
16:00 - 16:30
Shirley O'Dea (Avectas Group)
16:30 - 16:50
Repurposing old drugs for the treatment of sepsis
Selected Oral Communication - Afnan Ali (RCSI, Dublin, Ireland)
16:50 - 17:10
Development and therapeutic potential of NOSH-NSAIDs: A new class of anti-inflammatory pharmaceuticals that release nitric oxide and hydrogen sulphide
Selected Oral Communication - Khosrow Kashfi (City University of New York School of Medicine, New York, U.S.A.)

Session 4: Innate Immune signalling

Thursday 3 November 2016
18:30 - 21:00 Conference Dinner at the Phoenix Restaurant

Friday 4 November 2016
09:30 - 10:00
Visualising Pattern Recognition Receptor Signalling
Clare Bryant (Cambridge University, United Kingdom)
10:00 - 10:15
Martina Schroeder (Maynooth University, Ireland)
10:15 - 10:30
Investigating the regulation of IL-27 production
Marion Butler (Maynooth University, Ireland)
10:30 - 11:00
Regulation of inflammasome outcomes by SARM
Andrew Bowie (Trinity College Dublin, Ireland)
11:00 - 11:15
Adaptive evolution in TIR domain-containing adapter inducing IFN-β (TRIF) leads to discordance between human and mouse TRIF-dependent innate immune signaling
Selected Oral Communication - Edel Hyland (Queens University Belfast, Belfast, United Kingdom)
11:15 - 11:30
The effect of epigenetic modifications on Toll-like receptor 3 expression
Selected Oral Communication - Conor Hennessy (NUI Galway, Galway, Ireland)
11:30 - 12:00
Regulated Intramembrane Proteolysis and Spatial Segregation of Cytokine Signaling
Selected Oral Communication - Justin McCarthy (UCC, Cork, Ireland)
12:00 - 13:30 Lunch and Poster Session 2

Session 5: Impact of diet and exercise on inflammation/immunity

Friday 4 November 2016
13:30 - 14:00
Exercise protects from cancer by regulation of immune function
Pernille Hojman (University of Copenhagen)
14:00 - 14:30
Skeletal muscle contraction and the regulation of metabolism in health and type 2 diabetesvbNewLinevbNewLine
Donal O'Gorman (Dublin City University, Ireland)
14:30 - 15:00
Investigation of the links between the commensal gut microbiota, host immunity and metabolism using elite athletes as a model cohort
Paul Cotter (Teagasc, Ireland)
15:00 - 15:30
Nutritional Modulation of Metabolic-Inflammation
Helen Roche (University College Dublin, Ireland)
15:30 - 16:00 Refreshment Break

16:00 - 17:00
IASBS prize lecture
Cormac Taylor (UCD)

Session 6: Breakout session-career options after a PhD

Friday 4 November 2016
17:00 - 17:30
Bench to Business: Building a Biotech company
Richard Fernandes (Luxcel BioSciences Ltd)
17:30 - 18:00
Life after the lab: Careers in scientific publishing and learned societies
Niamh O'Connor (Director of Publishing, Biochemical Society and Portland Press)
18:00 Close of Conference