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Lipid Mediators in Ageing and Disease

5—6 January 2017

Aston University, UK



Organizers:
Irundika Dias (Aston University, United Kingdom)
Helen Griffiths (Aston University, United Kingdom)
Corinne Spickett (Aston University, United Kingdom)
Thursday 5 January 2017
Anna Nicolaou (The University of Manchester, United Kingdom)
09:00 - 09:50 Registration

09:50 - 10:00 Welcome and Introduction

10:00 - 10:40
Structural Elucidation of Novel Mediators in Resolution of Infectious Inflammation & Tissue Regeneration
Keynote Lecture- Charles Serhan (Brigham and Women's Hospital/Harvard Medical School, U.S.A.)
10:40 - 11:00 Refreshment Break

11:00 - 11:30
Bioactive lipid mediators in the regulation of cutaneous inflammation
Anna Nicolaou (University of Manchester, United Kingdom)
11:30 - 11:50
Pro-resolving lipid mediators are critical in modulating T-helper cell responses: implications for modulation of chronic inflammation and autoimmunity
Selected Oral Communication- Valerio Chiurchiu (University of Rome, Italy)
11:50 - 12:10
Regulation of 5-lipoxygenase expression in inflammation and cancer
Selected Oral Communication- Dieter Steinhilber (University of Frankfurt, Germany)
12:10 - 12:30
Lipoxin A4 as a therapeutic in diabetes-associated atherosclerosis and kidney disease
Selected Oral Communication- Eoin Brennan (University College Dublin, Ireland)
12:30 - 13:00 Flash Poster Presentations

13:00 - 14:30 Lunch with Poster Session

14:30 - 15:00
Pharmacological inhibition of the proinflammatory action of phospholipid oxidation products
Valery Bochkov (University of Graz, Austria)
15:00 - 15:20
DHA-derived oxylipins, neuroprostanes and protectins, differentially and dose-depen dently modulate the inflammatory response in human macrophages: putative mechanisms through PPAR activation.
Selected Oral Communication- Cécile Gladine (INRA, France)
15:20 - 15:40
Maresin conjugates in tissue regeneration promote the clearance of bacterial infections and are organ protective
Selected Oral Communication- Jesmond Dalli (William Harvey Research Institute, United Kingdom)
15:40 - 16:10 Refreshment Break

16:10 - 16:40
Pro-resolving pathways to terminate inflammation and promote tissue repair
Mauro Perretti (University of London, United Kingdom)
16:40 - 17:10
Apoptotic Cell-derived Extracellular Vesicles – a matter of life and death.
Andrew Devitt (Aston University, United Kingdom)
17:10 - 17:30
Apoptotic cell-derived extracellular vesicles – defining the lipid mediator composition
Selected Oral Communication- Ivana Milic (Aston University, United Kingdom)
17:30 - 18:30 Drinks Reception

18:45 Conference Dinner

Friday 6 January 2017
09:00 - 09:30
Mapping the lipidomes of innate immune cells
Valerie O'Donnell (Cardiff University, United Kingdom)
09:30 - 10:00
Oxysterols in the progression of atherosclerosis and Alzheimer's disease
Giuseppe Poli (University of Torino, Italy)
10:00 - 10:20
Statin intervention reduce circulating oxysterols in hypercholesterolemic patients
Selected Oral Communication- Irundika H Dias (Aston University, United Kingdom)
10:20 - 10:40
Quality of fish oil has an impact on lipid composition in intermediate and low density lipoprotein subclasses
Selected Oral Communication- Amanda Rundblad (Oslo and Akershus University College, Norway)
10:40 - 11:00 Refreshment Break

11:00 - 11:30
Midlife blood metabolites and cognition in the 1946 British birth cohort
Petroula Proitsi (University College London, United Kingdom)
11:30 - 11:50
Isoprostanoids profiling to study the muscle aging process of aged master athletes.
Selected Oral Communication- Justine Bertrand-Michel (Lipidomic facility Inserm, France)
11:50 - 12:10
Experimental approaches for studying the subcellular localization of lipid mediator biosynthetic proteins in situ
Selected Oral Communication- Jana Gerstmeier (Friedrich-Schiller-University Jena, Germany)
12:10 - 12:30
Resolvin E1 attenuates inflammatory signalling and related atrophy in skeletal muscle myotubes
Selected Oral Communication- Luke Baker (Loughborough University, United Kingdom)
12:30 - 13:00 Flash Poster Presentations

13:00 - 14:30 Lunch with Poster Session

14:30 - 15:00
Omega-3 fatty acids and inflammatory processes: From molecules to man
Philip C. Calder (University of Southampton, United Kingdom)
15:00 - 15:20
Odd-Chain Fatty Acids Predict Insulin Sensitivity in People with T2DM and Protect HepG2 Cells from Palmitate- Induced Insulin Resistance Via PPARα
Selected Oral Communication- John Ikwuobe (Aston University, United Kingdom)
15:20 - 15:40
The effect of obesity on adipose tissue fatty acid composition and lipid mediators, and their response to chronic marine omega-3 fatty acid supplementation: The BIOCLAIMS study at the University of Southampton.
Selected Oral Communication- Helena Fisk (University of Southampton, United Kingdom)
15:40 - 16:00 Closing Remarks and Depart