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ROS and Mitochondria in Nervous System Function and Disease

27—29 March 2017

Charles Darwin House, London, UK

Reactive oxygen species (ROS) and mitochondria have key roles in neuronal function and neurological disease. Many outstanding questions remain about the basic mechanisms involving ROS and normal neuronal function and how they contribute to disease. This meeting will provide a cutting edge forum to address these issues by bringing together leading scientists, as well as researchers who are new to the field, to present their current research and discuss future directions.


ROS have long been known to be damaging by-products of metabolism, but the concept that ROS modification of proteins plays a signalling role in the general function of neurons is rapidly gaining ground. Mitochondria generate ATP, but are also important organelles in neuronal signal transduction and are the main source of ROS. This meeting will explore how the roles of ROS and mitochondria intersect in neuronal signal transduction, the underlying biochemical processes and how these mechanisms modulate neuronal function. ROS and mitochondrial signalling are vitally important, not only in nervous system development and function, but also in neurological disease. The meeting will be relevant to researchers interested in basic mechanisms, but also those studying clinical aspects relating to diseases such as Parkinson’s disease, Alzheimer's disease and Amyotropic Lateral Sclerosis among many others.


The major themes of the meeting are:


1.    ROS in signal transduction

2.    Mitochondria as a signalling organelle

3.    ROS and mitochondrial signalling in neuronal function

4.    New techniques for visualising ROS and mitochondria

5.     ROS and mitochondrial signalling in translational medicine


Joseph M. Bateman (King's College London, United Kingdom)
Sean Sweeney (University of York, United Kingdom)
Monday 27 March 2017
13:00 - 13:35 Registration

13:35 - 13:50
Welcome and Introduction
Joseph Bateman (King’s College London, UK) & Sean Sweeney (University of York, UK)
13:50 - 14:20
Intra- and inter-cellular signaling pathways promoting redox homeosasis in the brain
Giles Hardingham (University of Edinburgh, United Kingdom)
14:20 - 14:50
The physiology and pathophysiology of Mitochondrial calcium signaling
Michael Duchen (University College London, United Kingdom)
14:50 - 15:20
Targeting of mitochondria by ROS in neurodegeneration
Andrey Abramov (UCL Institute of Neurology, UK)
15:20 - 16:00 Refreshment Break

16:00 - 16:30
Mitochondria as signaling organelles
Navdeep Chandel (Northwestern University, U.S.A.)
16:30 - 16:50
Selected Oral Communication- Increased mitophagy and mitochondrial DNA (mtDNA) turnover in defects of mtDNA maintenance associated with severe neurodegenerative disease.
Joanna Poulton (Oxford University, UK)
16:50 - 17:35
Regulation of circuit function and behavior by ambient oxygen levels
Mario de Bono (MRC Laboratory of Molecular Biology, United Kingdom)
17:35 - 17:55
Flash Poster Presentations
17:55 - 19:00 Drinks reception with Poster Session 1

Tuesday 28 March 2017
09:30 - 10:30
Energy and Metabolism Early Career Research Award
Mechanisms of mitochondrial redox control over health and disease
Edward Chouchani (Dana–Farber Cancer Institute, Harvard Medical School, USA)
10:30 - 11:00 Refreshment Break

11:00 - 11:30
Regulation of oxidative stress responses in neurons: Coupling of an AP-1 response to constitutive defense mechanisms
Sean Sweeney (University of York, UK)
11:30 - 12:00
The role of mitochondrial dysfunction and ROS in chemotherapy-induced painful neuropathy
Sarah Flatters (King's College London, United Kingdom)
12:00 - 12:20
Flash Poster Presentations
12:20 - 14:00 Lunch with Poster Session 2

14:00 - 14:30
Disease Stratification in Parkinson's disease - challenges and opportunities
Oliver Bandmann (University of Sheffield, United Kingdom)
14:30 - 15:00
The Ras-ERK-ETS pathway modifies mitochondrial retrograde signalling to alleviate the effects of neuronal mitochondrial dysfunction
Joseph Bateman (King’s College London, UK)
15:00 - 15:20
Selected Oral Communication- The mitochondrial Lon protease plays a key role in sex- and age-specific oxidative stress adaptation and redox signaling pathways
Kelvin Davies (University of Southern California, USA)
15:20 - 15:50 Refreshment Break

15:50 - 16:20
Mutations in mitochondria aminoacyl tRNA-synthetase genes impair mitochondrial metabolism in neurons
Rita Horvath (Newcastle University, United Kingdom)
16:20 - 16:40
Selected Oral Communication- Oncogene-selective sensitivity to synchronous cell death following modulation of the amino acid nutrient cystine
Richard Lamb (Liverpool Hope University, UK)
16:40 - 17:00
Selected Oral Communication- Mitochondrial dysfunction in a rare form of childhood epilepsy: CLN5 disease.
Kate Shipley (Cardiff University)
17:00 - 18:00
Centenary Award
Twists and Turns in the Prostacycli-Nitric Oxide story. Where from here?
Salvador Moncada (University of Manchester, UK)
19:00 Conference Dinner at Drake and Morgan

Wednesday 29 March 2017
09:00 - 09:20
Selected Oral Communication- Utilising carbon nanotubes to detect and investigate reactive oxygen species
Jacqueline Hicks (University of Nottingham)
09:20 - 09:50
Reactive Oxygen Species Regulate Activity-Dependent Structural Plasticity.
Matthias Landgraf (University of Cambridge, United Kingdom)
09:50 - 10:20
PINK1 mRNA is transported with mitochondria and locally translated to support axonal mitophagy
Angelika Harbauer (Harvard University, USA)
10:20 - 10:50 Refreshment Break

10:50 - 11:20
Mitochondrial dysfunction in neonatal hypoxic-ischaemic brain injury
Claire Thornton (King’s College, London, United Kingdom)
11:20 - 11:50
Mechanisms of mitochondrial homeostasis in Parkinson's disease – lessons from Drosophila
Alex Whitworth (MRC Mitochondrial Biology Unit, United Kingdom)
11:50 - 12:10
Selected Oral Communication- Mitochondrial ROS as signal transduction mediators in brain physiology
Plamena Angelova (University College London, UK)
12:10 - 12:30
Selected Oral Communication- Regulators of Wallerian degeneration control axonal degeneration caused by mitochondrial toxins
Andrea Loreto (University of Cambridge, UK)
12:30 - 12:45
Concluding remarks
12:45 Packed Lunch and Departure