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Bioinformatics Tools for Functional Annotation and Variance Modelling

27 April 2016

Charles Darwin House, London, UK

Each section will be primarily focused on the tools and resources developed by the trainers leading the session. Other popular tools and resources will be mentioned in passing as well as referenced in the pre-course training material. To maintain a focus to each section as well as providing a narrative that links each session, an example family of proteins will be used.  

1 - Functional Annotation of Protein Sequence and Structure

An introduction to the bioinformatics tools and resources for automatically assigning functions to gene products using sequence and structure and how they perform in the community wide blind prediction experiments (CAFA). 


The session will use the tools and methods developed in the CATH ( and FunTree ( resources as exemplars, with students given the opportunity to explore other tools 

presented in the pre/post course training material.


2 - Modelling Variation: Methods and Tools for the Molecular Modelling of Single Nucleotide Polymorphisms

Elucidating the molecular mechanisms linking a mutation’s impact with phenotype is very often non-trivial, and functional interpretation of mutation data has consequently lagged behind generation of the data from modern high-throughput techniques. This is complicated by the multitude of effects a mutation may have on a proteins function. 


Using the computational tools developed in the Blundell group as exemplars of the range of computational that have been developed to predict structural and functional consequences of mutations in order to reveal molecular mechanisms leading to clinical and experimental phenotypes.


3 - Applications in Drug Discovery

This will include an introduction of web-based tools available to assess the tractability of a protein as a drug target, using protein family, protein structure, protein interaction and chemical information. 

Nicholas Furnham (London School of Hygiene and Tropical Medicine, UK)
Frances Pearl (University of Sussex, UK)
Wednesday 27 April 2016
David Ascher (University of Cambridge)
Ian Sillitoe (University College London, United Kingdom)
08:45 - 09:30 Registration

Session 1 - Functional Annotation of Protein Sequence and Structure


Wednesday 27 April 2016
09:30 - 10:30
Annotation Using Relationships in Sequence, Structure and Function
Introduction and Lecture
10:30 - 10:45 Refreshment Break

10:45 - 12:00
Tools for Functional Annotation: The CATH and FunTree Resources

Session 2 - Modelling Variation: Methods and Tools for the Molecular Modelling of Single Nucleotide Polymorphisms

Wednesday 27 April 2016
12:00 - 13:00
Computational Methods of Modeling SNPs
Theoretical Lecture
13:00 - 14:00 Lunch

14:00 - 15:15
Computational Tools for Modelling Molecular Consequences of SNPs

Session 3 - Applications in Drug Discovery

Wednesday 27 April 2016
15:45 - 16:15
An Introduction to How Using Functional Annotations and SNP Modelling are Used in the Drug Discovery Process
Theoretical Lecture
16:15 - 17:00
Applications to Examples in Cancer and Infectious Disease Drug Discovery
17:00 - 17:15 Feedback and Close