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80th Harden Conference: Machines on Genes IV - Mechanisms of Actions of Large Macromolecular Machines on Genes Across Biological Scales

31 July—5 August 2016

Shrigley Hall Hotel, Macclesfield, UK (15 miles from Manchester)

This meeting brings together a highly interdisciplinary group of scientists with the common goal of dissecting the operating principles of large macromolecular machines acting on nucleic acids, using structural and functional approaches across all biological length and time scales. The 2016 Harden conference follows from previous very successful MoG meetings, held already twice in the UK and once in the USA. The biannual MoG meetings consolidate the long-running FASEB Nucleic-Acid Enzymes conferences and will alternate between Europe and the USA. With recent technological advances in imaging including single molecule imaging (visible light) and cryo-electron microscopy, a series of large and sometimes rare/transient macromolecular machines/assemblies have been characterised, providing unprecedented mechanistic insights into these important machines. The meeting showcases recent advance in the field, with an emphasis on mechanistic insights using a diverse range of approaches. The interdisciplinary nature of work showcased at the meeting brings together scientists from different disciplines, and we expect a strong synergy between the participants from different continents. A large number of oral presentations will be selected from the abstracts, and the selected talks, poster presentations, and social activities will provide students and postdoctoral fellows opportunities to exchange ideas and formulate new collaborations. Bursaries are available for students. The meeting will also feature several organized panel discussions to help junior colleagues with various topics related to careers in science. The 2016 MoG meeting will facilitate interactions to inspire new science and innovations in the area of nucleic-acid structural and mechanistic biology. 

Xiaodong Zhang (Imperial College London, United Kingdom)
Antoine van Oijen (University of Wollongong, Australia)
Andrej Luptak (University of California, U.S.A.)
Sunday 31 July 2016
15:00 - 17:30 Registration

17:30 - 18:30 Drinks Reception

18:30 - 20:00 Dinner

20:00 - 21:00
The use of recent advances in electron microscopy to study ribosome structure.
Keynote Lecture- Venki Ramakrishnan (MRC Cambridge, United Kingdom)
Monday 1 August 2016
09:00 - 09:30
Visualizing recombination and replication machines on single molecules of DNA – genes
Stephen Kowalczykowski (University of California, Davis, U.S.A.)
09:30 - 10:00
A new paradigm for base excision repair
Brandt Eichman (Vanderbilt University, U.S.A.)
10:00 - 10:20
tructural insights into the regulation of RecBCD helicase-nuclease complex from cryo-EM
Selected Oral Communication- Martin Wilkinson (Imperial College london, United Kingdom)
10:20 - 10:40
Analysis of double-strand break processing in vivo at nucleotide-level resolution reveals roles for RecA and chi sites in limiting resection
Selected Oral Communication- Anjana Badrinarayanan (Massachusetts Institute of Technology, U.S.A.)
10:40 - 11:00
Mechanism of directional DNA site-specific recombination by serine integrases
Selected Oral Communication- Marshall Stark (University of Glasgow, United Kingdom)
11:00 - 11:20 Tea/Coffee Break

11:20 - 11:50
Resolution of Holliday junctions in eukaryotes : The structure of the GEN1-DNA junction complex
David Lilley (University of Dundee, United Kingdom)
11:50 - 12:10
Mechanism of translocation-coupled nucleolytic activity of an ATP-dependent restriction-modification enzyme
Selected Oral Communication- Sai Kayarat (Indian Institute of Science Education and Research, India)
12:10 - 12:30
Inhibitors of Human Flap Endonuclease 1
Selected Oral Communication- Jane Grasby (University of Sheffield, United Kingdom)
12:30 - 12:50
A new paradigm for nucleotide excision repair
Selected Oral Communication- Pawel Zawadzki (Oxford University, United Kingdom)
12:50 - 14:00 Lunch

14:00 - 16:00 Poster Session (Odd numbers)

16:00 - 16:30 FEI Presentation

16:30 - 17:00
Activation of MUS81 structure-selective endonuclease by formation of the SMX complex
Stephen West (The Francis Crick Institute, United Kingdom)
17:00 - 17:30
Trapping transient states in DNA mismatch repair
Titia Sixma (Netherlands Cancer Institute, Netherlands)
17:30 - 17:45 Tea/Coffee Break

17:45 - 18:15
Elucidating the roles of Primase-Polymerases in DNA replication and repair
Aidan Doherty (University of Sussex, United Kingdom)
18:15 - 18:35
Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution
Selected Oral Communication- David Rueda (Imperial College London, United Kingdom)
19:00 - 20:30 Dinner

20:30 - 21:20
Biochemical Society Centenary Award
Transcription of the genome: from molecular movies to regulatory systems
Patrick Cramer (Max Planck Institute for Biophysical Chemistry, Germany)
Tuesday 2 August 2016
09:00 - 09:30
Regulation of polyA tail length by cellular machines
Lori Passmore (MRC Laboratory of Molecular Biology, United Kingdom)
09:30 - 10:00
The hammerhead ribozyme: A machine that is a gene
Barbara Golden (Purdue University, United Kingdom)
10:00 - 10:20
The structure of the Dcp2-Dcp1-Edc1 complex reveals the activated conformation of the mRNA decapping enzyme
Selected Oral Communication-Stefanie Jonas (ETH Zürich, Switzerland)
10:20 - 10:40
Yeast ribosome synthesis factor Tsr1 acts as a structural mimic of translational GTPases.
Selected Oral Communication- Atlanta Cook (Wellcome Trust Centre for Cell Biology, United Kingdom)
10:40 - 11:00 Tea/ Coffee Break

11:00 - 11:30
Quality Control During 40S Ribosome Assembly
Katrin Karbstein (Scripps Research Institute, U.S.A.)
11:30 - 12:00
In vivo single-molecule studies of the transcription organization in the bacterial nucleoid
Achillefs Kapanidis (University of Oxford, United Kingdom)
12:00 - 12:20
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
Selected Oral Communication- Ines Fonfara (Max Planck Institute for Infection Biology, Germany)
12:20 - 13:30 Lunch

13:30 - 18:00 Free time

18:00 - 19:00 Networking event- Meet the Experts

19:00 - 20:30 Dinner

20:30 - 21:20
Molecular mechanisms of RNA degradation: the exosome complex
The EMBO Keynote Lecture- Elena Conti (Max Planck Institute of Biochemistry, Germany)
Wednesday 3 August 2016
09:00 - 09:30
Bacterial chromosome unlinking and segregation
David Sherratt (University of Oxford, United Kingdom)
09:30 - 10:00
Reprogramming the Genetic Code
Jason Chin (MRC Laboratory of Molecular Biology, United Kingdom)
10:00 - 10:20
The C-terminal domain of ParB enables DNA binding and bridging interactions to condense the bacterial centromere
Selected Oral Communication- Gemma Fisher (University of Bristol, United Kingdom)
10:20 - 10:40
Stochastic activation of a DNA damage response causes cell-to-cell mutation rate variation
Selected Oral Communication- Stephan Uphoff (University of Oxford, United Kingdom)
10:40 - 11:10 Tea/ Coffee Break

11:10 - 11:30
DNA recognition and packaging during viral assembly
Selected Oral Communication- Fred Antson (University of York, United Kingdom)
11:30 - 11:50
Structural coordination between the CMG helicase and the leading strand polymerase epsilon in the eukaryotic replisome
Selected Oral Communication- Jin Chuan Zhou (The Francis Crick Institute, United Kingdom)
11:50 - 12:50
The seemingly unending complexity of nucleic-acid dependent AAA+ ATPases: some assembly required (instructions not included)
Royal Society of Chemistry Gait Lectureship- James Berger (John Hopkins University, U.S.A.)
12:50 - 14:00 Lunch

14:00 - 16:00 Poster Session (Even numbers)

16:00 - 16:30
Architecture and Function of the Eukaryotic ReplisomevbNewLine
Michael O'Donnell (Rockefeller University, U.S.A.)
16:30 - 17:00
Single molecule investigations of transcription factor kinetics living bacterial cells
Johan Elf (Uppsala University, Sweden)
17:00 - 17:20
Single-molecule visualisation of fast polymerase turnover in the bacterial replisome
Selected Oral Communication- Jacob Lewis (University of Wollongong, Australia)
17:20 - 17:45 Tea/ Coffee Break

17:45 - 18:15
The consequences of replisome passage on gene expression
Houra Merrikh (University of Washington , U.S.A.)
18:15 - 18:45
Gene expression regulation at high resolution
Stirling Churchman (Harvard Medical School, U.S.A.)
19:00 - 20:30 Dinner

20:30 - 21:20
Biochemical Society Colworth Medal
The hidden complexities of bacterial transcription
David Grainger (University of Birmingham, United Kingdom)
Thursday 4 August 2016
09:00 - 09:30
Structure and mechanism of the Ino80 chromatin remodelling complex
Dale Wigley (Imperial College London, United Kingdom)
09:30 - 10:00
Role of DNA mechanics in nucleosome transfer
Michelle Wang (Cornell University, U.S.A.)
10:00 - 10:20
The 7-repeat domain of yeast eIF4B is essential for modulation of the eIF4A conformational cycling and for stimulation of its helicase activity
Selected Oral Communication- Ulf Harms (University of Muenster, Germany)
10:20 - 10:40
Modular assembly of the bacterial large ribosomal subunit
Selected Oral Communication- Joseph Davis (The Scripps Research Institute, USA)
10:40 - 11:00
A localized phosphoprotein network fine-tunes Ddc2(ATRIP)-RPA assembly in DNA damage response
Selected Oral Communication- Luke Yates (Imperial College London, United Kingdom)
11:00 - 11:30 Tea/ Coffee Break

11:30 - 12:00
New tricks for an old dog: novel roles for RNA Polymerase III gene transcription machinery in oxidative stress and cancer
Alessandro Vannini (The Institute of Cancer Research, United Kingdom)
12:00 - 12:30
Structure and function of the major variant bacterial sigma factor for enhancer dependent transcription
Martin Buck (Imperial College London, United Kingdom)
12:30 - 15:00 Lunch/ Free time

15:00 - 16:00 Networking Event- Job Hunting/ Funding

16:00 - 16:30
Zika, Dengue & West Nile: Viral RNA Structure and the Art of Molecular Warfare
Jeffrey Kieft (University of Colorado, Denver, U.S.A.)
16:30 - 17:00
Molecular insight into RNA polymerase I and III transcription
Christoph Mueller (EMBL, Germany)
17:00 - 17:30
Structural biology and structural biophysics of transcription
Richard Ebright (Rutgers University, USA)
17:30 - 17:50
Mechanism of Promoter Melting by the Bacterial RNA-polymerase
Selected Oral Communication- Andrey Feklistov (The Rockefeller University, U.S.A.)
17:50 - 18:10
Sequence-Encoded Pause Signals Modulate Initial Transcription in Bacteria
Selected Oral Communication- David Bauer (University of Oxford, United Kingdom)
19:00 Drinks reception/ Conference Dinner