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Protein S-palmitoylation: from Mechanism to Application

21—23 September 2016

St Hilda's College, Oxford, UK

William Fuller (University of Dundee, United Kingdom)
Piers Hemsley (University of Dundee and the James Hutton Institute, United Kingdom)
Wednesday 21 September 2016
13:00 - 14:00 Registration

14:00 - 14:15 Welcome and Introduction

Session 1: Regulating Reversible S-palmitoylation

14:15 - 14:45
Mechanism and Function of zDHHC S-Palmitoyltransferases
Maurine Linder (Cornell University, U.S.A.)
14:45 - 15:15
Substrate selectivity in the zDHHC family of S-acyltransferases
Luke Chamberlain (University of Strathclyde, United Kingdom)
15:15 - 15:30
Agonist-induced S-palmitoylation of a novel site within the β2-adrenergic receptor is associated with a novel intracellular itinerary and mechanism of receptor desensitization
Selected Oral Communication - Naoko Adachi (Kobe University)
15:30 - 16:00 Refreshment Break

16:00 - 16:30
Identification of novel protein depalmitoylases that regulate palmitate turnover on N-Ras
Elizabeth Conibear (Centre for Molecular Medicine and Therapeutics, Canada)
16:30 - 16:45
Structural features of the acyl protein thioesterases APT1 and APT2 discriminate isoform-selective competitive inhibitors
Selected Oral Communication - Sang Joon Won (University of Michigan)
16:40 - 17:00
Dynamics of a palmitoylation cascade
Selected Oral Communication - Laurence Abrami (epfl)
17:00 - 17:30 Flash Poster Presentations

17:30 - 19:00 Poster Session 1

19:00 Dinner

Session 2: Regulation of Cellular Function by S-palmitoylation

09:00 - 09:30
Unpicking the workings of the cell surface acyl transferase DHHC5
William Fuller (University of Dundee, United Kingdom)
09:30 - 10:00
S-acylation and cell specific control of ion channel physiology
Michael Shipston (University of Edinburgh, United Kingdom)
10:00 - 10:15
Control of cancer growth and drug sensitivity byEGFR palmitoylation
Selected Oral Communication - Eric Witze (University of Pennsylvania School of Medicine)
10:15 - 10:30
Autophagy proteins are getting fat: Emergence of palmitoylation as a regulator of autophagy and neurodegeneration
Selected Oral Communication - Dale Martin (University of British Columbia)
10:30 - 11:00 Refreshment Break

11:00 - 11:30
DHHC9 in the development and function of neuronal circuits
Shernaz Bamji (University of British Columbia, Canada)
11:30 - 12:00
S-acylation in plants - the same but different
Piers Hemsley (University of Dundee & The James Hutton Institute, United Kingdom)
12:00 - 12:15
An essential role for palmitoylation in neurodevelopmental axon degeneration
Selected Oral Communication - Gareth Thomas (Temple University School of Medicine)
12:15 - 12:30
Dynamic S-acylation of the SNARE protein SNAP25
Selected Oral Communication - Jennifer Greaves (University of Strathclyde)
12:30 - 12:45
Breaking news and paper highlights (3 minute max talks submitted at registration)
12:45 - 13:45 Lunch

Session 3: New Tools and Approaches

13:45 - 14:15
Identification and modeling of palmitoylation systems
Gisou van der Goot (Ecole Polytechnique Fédérale de Lausanne, Switzerland)
14:15 - 14:45
Challenges and emerging approaches for targeting protein interfaces in Wnt signaling
Rami Hannoush (Genentech, Inc., U.S.A.)
14:45 - 15:00
Blocking substrate recruitment by DHHC-protein acyl transferase enzymes for therapeutic gain
Selected Oral Communication - Niall Fraser (University of Dundee)
15:00 - 15:30 Refreshment Break

15:30 - 16:00
APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells
Selected Oral Communication - Brent Martin (University of Michigan)
16:00 - 16:15
The molecular mechanism of a conserved regulatory region in zDHHC PAT C-termini
Selected Oral Communication - Krishna Reddy (University of South Florida)
16:15 - 16:30
Mass-tag labeling reveals site-specific and endogenous levels of protein S-fatty acylation
Selected Oral Communication - Emmanuelle Thinon (The Rockefeller University)
16:30 - 17:00
Emerging methods, requests for help and collaboration (3 minute max talks submitted at registration)
17:00 - 18:30 Poster Session 2

19:00 Conference Dinner

Session 4: S-palmitoylation Interplay with Membrane Dynamics

09:30 - 10:00
Ankyrin-G, zDDH5, and zDDHC8 and the Control of Plasma Membrane Dynamics
Paul Jenkins (University of Michigan, U.S.A.)
10:00 - 10:30
Palmitoylation-dependent membrane domains and endocytosis in cell stress
Donald Hilgemann (UT Southwestern, U.S.A.)
10:30 - 10:45
10:45 - 11:15 Refreshment Break

11:15 - 11:30
Regulation of the plant V-ATPase by S-acylation
Selected Oral Communication - Upendo Lupanga (University of Heidelberg)
11:30 - 11:45
Metabolic stress alters the balance between palmitoylation and glutathionylation of the Na pump regulatory protein phospholemman
Selected Oral Communication - Jacquie Howie (University of Dundee)
11:45 - 12:00
Exploring the links between the ZDHHC9 gene and intellectual disability
Selected Oral Communication - Marianna Kouskou (University of Strathclyde)
12:00 - 12:30 Concluding Remarks

12:30 Lunch and Depart