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81st Harden Conference: RNA and Disease

4—7 September 2016

Norton Park Hotel, Winchester, UK



In recent years, our understanding of RNA function and metabolism has expanded rapidly. High-throughput sequencing approaches have allowed the identification of a plethora of regulatory RNAs in pathogens and in human cells. We have characterized RNA regulatory pathways that are specific to individual cell types and compartments; for example mechanisms regulating the localised translation of mRNAs, an important feature of neural development. Moreover, ribo-regulation has been shown to play a key role in bacterial stress responses and in adaptation to a variety of micro environments within the host. Advances in structural biology, cell biology and imaging have revealed a stunning diversity in the way RNA interacts with proteins, localises within cells, and responds to or facilitates pathogen invasion. 

Our molecular insight into RNA regulation has revealed associations to a broad range of pathologies from ataxia to cancer to infective disorders. The aim of this meeting is to provide a forum to explore the science linking RNA and disease. The discussions will focus on the work of speakers and delegates, on recent technological advances and on future research directions. They also focus on how specific links between RNA and disease provide the basis for the future development of therapeutics.

Organizers:
Kristine Arnvig (University College London, United Kingdom)
Andres Ramos (University College London, United Kingdom)
Sunday 4 September 2016
15:00 - 17:00 Registration

17:00 - 17:15 Welcome

Session 1

Sunday 4 September 2016
17:15 - 17:45
Some thoughts on why bacteria use regulatory RNAs
Gerhart Wagner (Uppsala University, Sweden)
17:45 - 18:15
The post-transcriptional response to bulky-adduct DNA damage
Anne Willis (MRC Toxicology Unit, University of Leicester, United Kingdom)
18:15 - 19:15 Flash poster presentations

19:30 - 21:30 Welcome reception and dinner

Session 2

Monday 5 September 2016
09:00 - 09:30
Roles for PARP14 in selective post-transcriptional regulation of gene expression in inflammation and thrombosis
Dorian Haskard (Imperial College London, United Kingdom)
09:30 - 10:00
Post-transcriptional control by multi-functional RNA-binding proteins: from infertility to mechanisms
Nicola Gray (University of Edinburgh, United Kingdom)
10:00 - 10:30 Selected oral communications

10:00 - 10:15
Regulation of initial poly(A) tail size may explain the therapeutic effects of polyadenylation inhibition
Cornelia de Moor (University of Nottingham, United Kingdom)
10:15 - 10:30
Understanding the role of eIF4B in the pathogenesis of Diffuse Large B-Cell Lymphoma
Ana Quintas (MRC Toxicology Unit, United Kingdom)
10:30 - 11:00 Refreshments

Session 3

Monday 5 September 2016
11:00 - 11:30
mRNA target selection, architectural activity and regulation by the oncofetal protein ZBP1
Andres Ramos (University College London, United Kingdom)
11:30 - 12:00
New approaches unravel functions of RNA-binding proteins in bacterial virulence
Joerg Vogel (University of Wuerzburg, Germany)
12:00 - 12:30 Selected oral communications

12:00 - 12:15
Specific G-quadruplex ligands regulate the alternative splicing of Bcl-x
Cyril Dominguez (University of Leicester, United Kingdom)
12:15 - 12:30
Ribosomal expansion segments as targets for antimicrobials
Lizzette Gomez Ramos (Georgia Institute of Technology, U.S.A.)
12:30 - 14:00 Lunch

Session 4

Monday 5 September 2016
14:00 - 14:30
Regulation of gene expression by proteins bound to retrotransposon-derived RNA elements
Jernej Ule (UCL Institute of Neurology, United Kingdom)
14:30 - 15:00
Close encounters between Salmonella and horizontally acquired small RNAs
Shoshy Altuvia (The Hebrew University of Jerusalem, Israel)
15:00 - 15:30 Selected oral communications

15:00 - 15:15
A novel cytoprotective function for the DNA repair protein Ku in regulating p53 mRNA translation and function
Stefania Millevoi (INSERM, France)
15:15 - 15:30
A novel mechanism for bacteriophage encoded inhibition of the RNA degradosome assembly
Steven Hardwick (University of Cambridge, United Kingdom)
15:30 - 16:00 Refreshments

Session 5

Monday 5 September 2016
16:00 - 16:30
Role of a new endoribonuclease in selective mRNA turnover in B. subtilis
Ciaran Condon (Institut de Biologie Physico-Chimique, France)
16:30 - 17:00
Biogenesis and turnover of small RNAs in health and disease
Javier Caceres (MRC Human Genetics Unit. Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom)
17:00 - 18:30 Poster session 1

19:00 - 20:30 Dinner

20:30 - 21:30
2016 Novartis Medal and Prize Lecture
Identification of in vivo targets for small nucleolar RNAs and bacterial sRNAs
David Tollervey (WTCCB, University of Edinburgh, United Kingdom)

Session 6

Tuesday 6 September 2016
09:00 - 09:30
Unexpected versatility in bacterial riboswitches : lessons from Listeria
Pascale Cossart (Unité des Interactions Bactéries-cellules, Institut Pasteur, France)
09:30 - 10:00
Discovery of new post-initiation regulatory mechanisms in bacteria
Wade Winkler (University of Maryland, U.S.A.)
10:00 - 10:45 Selected oral communications

10:00 - 10:15
Unusual RNA/DNA structures and their function in disease
Natalia Gromak (University of Oxford, United Kingdom)
10:00 - 10:15
Regulation of RNA stability in development and disease.
Sarah Newbury (University of Sussex, United Kingdom)
10:30 - 10:45
Regulated assembly and diversity of lipopolysaccharide by non-coding sRNAs
Satish Raina (Gdansk University of Technology, Poland)
10:45 - 11:15 Refreshments

Session 7

Tuesday 6 September 2016
11:15 - 11:45
Regulation of neuronal granules in space and time
Florence Besse (Institute of Biology Valrose, France)
11:45 - 12:15
The dynamic machinery of bacterial RNA degradation, processing and riboregulation
Ben Luisi (University of Cambridge, United Kingdom)
12:15 - 13:00 Selected oral communications

12:15 - 12:30
Characterisation of DrrS, a small RNA in Mycobacterium tuberculosis
Alexandra Moores (University College London, United Kingdom)
12:30 - 12:45
miRISC assembly and function is initiated by the interaction of phosphorylated AGO2 with the tumour suppressor LIMD1
Tyson Sharp (Queen Mary University London, United Kingdom)
12:45 - 13:00
TRBP and PACT pose stoichiometric questions for Dicer complex assembly
Michael Plevin (University of York, United Kingdom)
13:00 - 14:00 Lunch

14:30 - 17:30 Excursion to Winchester

18:00 - 19:30 Poster session 3

20:00 - 22:30 Conference dinner

Session 8

Wednesday 7 September 2016
09:00 - 09:30
Regulation of the cell cycle by RNA binding proteins
Martin Turner (The Babraham Institute, United Kingdom)
09:30 - 10:00
Not just ncRNAs: overlap between protein coding and regulation
Gisela Storz (NIH, U.S.A.)
10:00 - 10:30 Selected oral communications

10:00 - 10:15
Small RNAs-mediated repression reveals positive control of translation initiation by a secondary structure within a bacterial mRNA
Maude Guillier (Institut de Biologie Physico-Chimique, France)
10:15 - 10:30
Signal transduction in microRNA biogenesis and the lifecycle of mammalian mRNAs
Dimitris Lagos (University of York, United Kingdom)
10:30 - 11:00 Refreshments

Session 9

Wednesday 7 September 2016
11:00 - 11:30
RNA Arrays: A novel opportunity for RNA research
Anastasia J Callaghan (University of Portsmouth)
11:30 - 12:00
Structural polymorphism and inhibition of noncoding RNAs in human cancer
Gabriele Varani (University of Washington, U.S.A.)
12:15 Packed lunches and conference closes