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Autophagy Week

Autophagy Week


September 2013 sees the release of the latest volume of Essays in Biochemistry, 'Autophagy: Molecules and Mechanisms.' To celebrate, the Biochemical Society and Portland Press Limited are offering free access to relevant content in their publications. This includes a newly launched Themed Collection from the Biochemical Journal.

What is autophagy?


Autophagy (‘self-eating’) is an essential process important for cell survival and homoeostasis. Although widely studied, there are still a number of questions about the mechanisms governing autophagy that need to be addressed. In recent years, autophagy has emerged as an important player in human disease, and therefore understanding its biological role and regulation has become the latest challenge for researchers.


Themed Collection


The Biochemical Journal, published by Portland Press Limited on behalf of the Biochemical Society, has released its second Themed Collection. The collection is on autophagy and has been made freely available to all for three months.


Reviews & Papers from the Biochemical Journal 


Biochemistry of cardiomyopathy in the mitochondrial disease Friedreich's ataxia

Darius J. R. Lane, Michael Li Hsuan Huang, Samantha Ting, Sutharshani Sivagurunathan and Des R. Richardson


Aggrephagy: lessons from C. elegans

Qun Lu, Fan Wu and Hong Zhang


Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

Jisun Lee, Samantha Giordano and Jianhua Zhang


Structural basis for phosphorylation-triggered autophagic clearance of Salmonella

Vladimir V. Rogov, Hironori Suzuki, Evgenij Fiskin, Philipp Wild, Andreas Kniss, Alexis Rozenknop, Ryuichi Kato, Masato Kawasaki, David G. McEwan, Frank Löhr, Peter Güntert, Ivan Dikic, Soichi Wakatsuki and Volker Dötsch


Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability 

Jing Zou, Fei Yue, Xianhan Jiang, Wenjiao Li, Jinglin Yi and Leyuan Liu


Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts 

Qiuli Liang, Gloria A. Benavides, Athanassios Vassilopoulos, David Gius, Victor DarleyUsmar and Jianhua Zhang


PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress 

Joshua K. Salabei, Timothy D. Cummins, Mahavir Singh, Steven P. Jones, Aruni Bhatnagar and Bradford G. Hill


Glucose induces autophagy under starvation conditions by a p38 MAPK-dependent pathway 

Jose Félix MorunoManchón, Eva PérezJiménez and Erwin Knecht


Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival 

Luke R. G. Pike, Dean C. Singleton, Francesca Buffa, Olga Abramczyk, Kanchan Phadwal, JiLiang Li, Anna Katharina Simon, James T. Murray and Adrian L. Harris


Myostatin is a novel tumoral factor that induces cancer cachexia 

Sudarsanareddy Lokireddy, Isuru Wijerupage Wijesoma, Sabeera Bonala, Meng Wei, Siu Kwan Sze, Craig McFarlane, Ravi Kambadur and Mridula Sharma


Induction of oxidative stress, lysosome activation and autophagy by nanoparticles in human brain-derived endothelial cells 

Blanka Halamoda Kenzaoui, Catherine Chapuis Bernasconi, Seher GuneyAyra and Lucienne JuilleratJeanneret



Papers from Bioscience Reports


The invasion of tobacco mosaic virus RNA induces endoplasmic reticulum stress-related autophagy in HeLa cells

Li Li, Li Wang, Ruijing Xiao, Guoguo Zhu, Yan Li, Changxuan Liu, Ru Yang, Zhiqing Tang, Jie Li, Wei Huang, Lang Chen, Xiaoling Zheng, Yuling He and Jinquan Tan


Knockdown of cathepsin D in zebrafish fertilized eggs determines congenital myopathy

Carlo Follo, Matteo Ozzano, Claudia Montalenti, Massimo Mattia Santoro and Ciro Isidoro


Snapin deficiency is associated with developmental defects of the central nervous system

Bing Zhou, Yi‑Bing Zhu, Lin Lin, Qian Cai and Zu‑Hang Sheng



Early Career Research Award from Biochemical Society Transactions


Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers

Sovan Sarkar 



Papers from Clinical Science


Autophagy in disease: a double-edged sword with therapeutic potential

Wim Martinet, Patrizia Agostinis, Barbara Vanhoecke, Michael Dewaele and Guido R. Y. De Meyer


Dining in with BCL-2: new guests at the autophagy table

Marc Germain and Ruth S. Slack


Sirtuins and renal diseases: relationship with aging and diabetic nephropathy

Munehiro Kitada, Shinji Kume, Ai Takeda‑Watanabe, Keizo Kanasaki and Daisuke Koya


Cardioprotection against ischaemia/reperfusion by vitamins C and E plus n−3 fatty acids: molecular mechanisms and potential clinical applications

Ramón Rodrigo, Juan C. Prieto and Rodrigo Castillo


AMP-activated protein kinase, stress responses and cardiovascular diseases

Shaobin Wang, Ping Song and Ming‑Hui Zou


Ubiquitin–proteasome system inhibitors and AMPK regulation in hepatic cold ischaemia and reperfusion injury: possible mechanisms

Susagna Padrissa‑Altés, Mohamed Amine Zaouali, Ramon Bartrons and Joan Roselló‑Catafau


Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP

Bo‑Shi Wang, Yi‑Zhen Liu, Yang Yang, Yu Zhang, Jia‑Jie Hao, Hai Yang, Xiao‑Min Wang, Zi‑Qiang Zhang, Qi‑Min Zhan and Ming‑Rong Wang


Protein metabolism and gene expression in skeletal muscle of critically ill patients with sepsis

Maria Klaude, Maiko Mori, Inga Tjäder, Thomas Gustafsson, Jan Wernerman and Olav Rooyackers



Essays in Biochemistry


Autophagy: Molecules and Mechanisms
Guest edited by Jon Lane, Bristol, U.K.


This latest volume of Essays in Biochemistry explores the mechanics of autophagy (assembly, maturation and emerging of the autophagosome), early signalling events, and the varied roles of autophagy during aging and disease. Concise chapters provide self-contained summaries on all aspects of autophagy, written by leaders in the field.

Cell Signalling Biology






Cell Signalling Biology - Autophagy


A free online resource, written by one of the world's leading signalling experts - Professor Sir Michael Berridge. 


The Biochemist


The Biochemist


The Biochemist

Vol. 34 No. 2 April 2012

Features include mammalian autophagy, signals controlling autophagy and much more. 



Webcasts of presentations given at the Biochemical Society Hot Topic Event "Role of Mitophagy in Physiology and Pathology" held in December 2011.


Sharon Tooze (Cancer Research, United Kingdom)


Michelangelo Campanella (University of London, United Kingdom)

John Lemasters (Medical University of South Carolina, U.S.A.)