Organizers:
Guy Brown (University of Cambridge, UK)
Michael Murphy (MRC Dunn Human Nutrition Unit, UK)
Timetable
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Welcome and introduction
14:00 - 16:00 Registration
Organizer welcome and introduction
Rod Capaldi (University of Oregon, USA)
Mitochondrial function and avoidance of apoptosis in an invertebrate extremophile
Steve Hand (Louisiana State University, USA)
Mitochondria as ATP consumers: the cell biology of the endogenous inhibitory protein IF-1
Michael Duchen (University College London, UK)
Mitochondria: Key to complexity
Guest Lecture - Author: Nick Lane (University College London, UK)
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In vivo energetics
Mitochondrial dysfunction in sepsis and multi-organ failure
Mervyn Singer (University College London, UK)
Exogenous cytochrome C restores myocardial cytochrome oxidase activity in late sepsis and improves survival
Selected oral communication - Richard Levy (New York Medical College, USA)
Do mitochondrial reactive oxygen species (ROS) cause damage to endoplasmic reticulum under systemic inflammatory response to endotoxin in liver?
Selected oral communication - Andrey Kozlov (Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austria)
Problems in assessing human skeletal muscle mitochondrial function in vivo: the example of type 2 diabetes
Selected oral communication - Graham Kemp (University of Liverpool, UK)
Energy metabolism in brain and muscle in vivo of patients with Huntington disease
Selected oral communication - Bjørn Quistorff (Copenhagen University, Denmark)
21:40 - 23:00 Welcome Reception
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ROS & RNS
Saturday 15 September 2007
In search of ¿superantioxidant¿. Mitochondria-targeted plastoquinone (SkQ) prevents peroxidation of mitochondrial lipids and prolongs lifespan
Vladimir Skulachev (Moscow State University, Russia)
Mitochondrial NO synthase
Cecilia Giulivi (University of California, USA)
Mitochondria and cell signaling by oxidized lipids
Victor Darley-Usmar (University of Alabama, USA)
A dynamic kinetic model of nitric oxide inhibition of mitochondrial oxygen consumption
Chris Cooper (University of Essex, UK)
Signalling events preventing mitochondrial permeability transition in monocytes/macrophages exposed to peroxynitrite
Orazio Cantoni (University of Urbino, Italy)
10:50 - 11:10 Coffee/tea break
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Signalling
Saturday 15 September 2007
Mitochondria-targeted antioxidants in the treatment of disease
Michael Murphy (MRC Dunn Human Nutrition Unit, UK)
Infrared A radiation triggers retrograde mitochondrial signalling to modulate gene expression
Selected oral communication - Peter Schroeder (Institut für Umweltmedizinische Forschung (IUF) an der Heinrich-Heine-Universität, Germany )
Tyrosine Phosphorylation of cytochrome c oxidase during cellular stress
Selected oral communication - Maik Hüttemann (Wayne State University School of Medicine, USA)
An intimate social triangle ¿ mitochondria, endoplasmic reticulum and plasma membrane. Who keeps company with who and why?
Selected oral communication - Mariusz Wieckowski (Nencki Institute of Experimental Biology, Poland)
12:30 - 14:30 Lunch and poster session 1
14:30 - 17:30 Self-guided walking tour of the Lake District
20:00 - 21:00 Poster session 1 and drinks reception
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Permeability transition and death
Saturday 15 September 2007
Toward a mitochondrial therapy of collagen VI muscular dystrophies
Paolo Bernardi (University of Padova, Italy)
The permeability transition: from molecular composition to reperfusion injury and cardioprotection
Andrew Halestrap (University of Bristol, UK)
The mitochondrial permeability transition in reperfusion injury
John Lemasters (Medical University of South Carolina, USA)
The permeability transition and its role in reperfusion injury
Martin Crompton (University College London, UK)
22:20 - 22:30 General discussion
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Uncoupling
Cardioprotective signalosomes migrate from sarcolemma to mitochondria to open MitoKATP and inhibit MPT
Plenary Lecture: Keith Garlid (Portland State University, USA)
Uncoupling proteins and ROS
Martin Brand (University of Cambridge, UK)
Detection of UCP 1 in thymocytes using confocal microscopy
Richard Porter (Trinity College Dublin, Ireland)
Mitochondrial ATP synthase levels in brown adipose tissue are governed by the c-Fo subunit P1 isoform
Selected oral communication - Barbara Cannon (Stockholm University, Sweden)
Fatty acids as regulators of the Uncoupling Proteins: Keys to an ongoing debate
Selected oral communication - Eduardo Rial (CSIC, Spain)
10:50 - 11:15 Coffee/tea break
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Bioenergetics and transport
Mitochondrial swelling induced by creation of lipophilic cation radicals by oxidoreductases of the outer membrane. A study using lucigenin as a probe
Selected oral communication - Nils-Erik Saris (University of Helsinki, Finland)
Modular Control and Regulation Analysis (MoCA) of muscle and heart contraction
Selected oral communication - Philippe Diolez (CNRS, France)
Respiratory control of cytochrome c oxidase
Selected oral communication - Peter Nicholls (University of Essex, UK)
Tissue-specific variations in mitochondrial respiratory control by multiple substrates in permeabilized muscle fibers
Selected oral communication - Helene Lemieux (Medical University of Innsbruck, Austria)
UCP2 contributes significantly to high mitochondrial proton leak in INS-1E pancreatic beta cells and attenuates glucose-stimulated insulin secretion
Selected oral communication - Charles Affourtit (University of Cambridge, UK)
12:30 - 14:30 Lunch and poster session 2
20:00 - 20:30 Discussion - Are mitochondrial ROS/RNS insignificant?
20:30 - 21:00 Discussion - Are mitochondria poorly designed?
Mitochondrial respiratory control: the Q-junction
Plenary lecture: Erich Gnaiger (University of Innsbruck, Austria)
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Brain and heart
Mitochondria in excitotoxicity
Plenary Lecture: David Nicholls (Buck Institute for Age Research, USA)
Intra-mitochondrial degradation of Tim23 is induced by apoptotic stimuli and curtails the survival of cells caspase-independently
Aviva Tolkovsky (University of Cambridge, UK)
Mitochondrial dysfunction and neurodegeneration
Simon Heales (Institute of Neurology, UK)
Nitro-alkenes & mitochondrial uncoupling: a novel cardioprotective pathway
Selected oral communication - Paul Brookes (University of Rochester Medical Center, USA)
Mitochondria in ischaemic pathology of the heart
Fabio Di Lisa (University of Padova, Italy)
10:50 - 11:10 Coffee/tea break
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Cell death
Mechanisms of cytochrome c release from mitochondria
Martin Ott (Karolinska Institute, Sweden)
Pulling the strings: Cause and consequence of mitochondrial dynamics
Selected oral communication - Werner Koopman (Radboud University, The Netherlands)
The role of ceramide channels in mitochondria-mediated apoptosis
Selected oral communication - Marco Colombini (University of Maryland, USA)
Mitochondria regulate apoptosis via the redox state of cytosolic cytochrome c
Selected oral communication - Vilma Borutaite (Kaunas University of Medicine, Lithuania)
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UMDF pathology
Mitochondrial function in skeletal muscle of arm and leg in patients with type 2 diabetes
Selected oral communication - Flemming Dela (University of Copenhagen, Denmark)
Intramitochondrial pH links modulation of potassium conductance with the mitochondrial permeability transition - implications for preconditioning and tolerance
Selected oral communication - Magnus Hansson (Lund University, Sweden)
Telomerase protects mitochondria and lowers oxidative stress
Selected oral communication - Gabriele Saretzki (University of Newcastle, UK)
Mitochondrial function and tumour growth control
Selected oral communication - Hanne Hagland (University of Bergen, Norway)
Fatty acids as regulators of mitochondrial uncoupling through UCPs and ANTs: structural requirements and coactivator demands
Selected oral communication - Jan Nedergaard (Stockholm University, Sweden)
The common deletion of the mitochondrial genome increases oxidative stress and alters cellular functions in human dermal fibroblasts in a dermal 3D environment
Selected oral communication - Jean Krutmann (Institut fuer umweltmedizinische Forschung an der Heinrich-Heine-Universitaet, Germany)
16:30 - 17:00 Coffee/tea break
Young member selected oral communication
Young member selected oral communication
Young member selected oral communication
Young member selected oral communication
Young member selected oral communication
18:30 - 22:30 Dinner and musical entertainment
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Fission, structure and function
Tuesday 18 September 2007
The role of nitric oxide and its control of mitochondrial dynamics in differentiating skeletal muscle
Selected oral communication - Emilio Clementi (University of Milan, Italy)
Mitofusin-2 regulates interaction between endoplasmic reticulum and mitochondria
Selected oral communication - Olga Martins de Brito (Venetian Institure of Molecular Medicine, Italy)
Characterising the cellular localisation, activation and activity of the mitochondria-targeted antioxidant MitoQ
Selected oral communication - Meredith Ross (University of Cambridge, UK)
Mitochondrial complex III declines with aging due to nitration of catalytic subunits
Charles Hoppel (Case Western Reserve University, USA)
Mitochondria: An attractive target for drug discovery and a concern for drug safety
Commercial talk: David Ferrick (Seahorse Bioscience, UK)
10:30 - 10:50 MiP general meeting
10:50 - 11:00 Organizer thanks and meeting close
11:00 - 11:30 Coffee/tea break
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