Organizers:
Andrew Munro (Manchester Interdisciplinary Biocentre, UK)
Martin J. Warren (University of Kent, UK)
Timetable
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Hot topics
Chair:
Andrew Munro (Manchester Interdisciplinary Biocentre, UK)
16:00 - 18:00 Registration
From Pasteur and Darwin to new enzyme activities
Alan Berry (University of Leeds, UK)
Stereochemical control on antibiotic-producing polyketide synthase multienzymes
Plenary Lecture - Peter Leadlay (University of Cambridge, UK)
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Coenzymes and metabolic pathways
Chair:
Chris Abell (University of Cambridge, UK)
Catalytic mechanisms of the catechol and carotenoid dioxygenases
Timothy Bugg (University of Warwick, UK)
Structures of acyl carrier protein synthase and ketoreductase: modules in type II polyketide synthesis, suggest a common structural motif for ACP recognition
Selected oral communication - Andrea Hadfield (University of Bristol, UK)
Structural determination of the 6,4-photolyase from Drosophila Melanogaster
Selected oral communication - Max Cryle (Max-Planck Institute for Medical Research, Heidelberg, Germany)
The riboflavin synthase family
Markus Fischer (University of Hamburg, Germany)
11:00 - 11:30 Coffee/tea break
Unusual molecular strategies of enzymes involved in heme and chlorophyll biosynthesis
Dieter Jahn (Technical University of Braunschweig, Germany)
The making of metabolic microcompartments in bacteria
Martin J. Warren (University of Kent, UK)
12:50 - 15:30 Lunch and free time
15:30 - 17:30 Poster session 1 (Posters P001-P027)
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Emerging concepts
Chair:
Nigel Scrutton (University of Manchester, UK)
Proton/electron coupling in cytochrome oxidase: insights from IR spectroscopy
Peter Rich (University College London, UK)
Assessing the chemical versatility of catalytic residues and cofactors
Selected oral communication - Gemma Holliday (EMBL-EBI, Cambridge, UK)
High-resolution ultrasonic spectroscopy for real-time monitoring of enzyme kinetics and protein conformational transitions
Selected oral communication - Vitaly Buckin (University College Dublin, Ireland)
The modification and degradation of heme in biological systems
Emma Raven (University of Leicester, UK)
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Redox enzymes
Chair:
Tadhg Begley (Cornell University, USA)
Mechanisms that control catalysis: what tunes reactivity of the NO synthase enzyme-product complex?
Dennis Stuehr (Lerner Institute, Cleveland, USA)
Structure-function studies on berberine bridge enzyme
Selected oral communication - Andreas Winkler (Graz University of Technology, Austria)
The crystal structure of CYP125: P450 drug targeting and cholesterol metabolism in the pathogen Mycobacterium tuberculosis
Selected oral communication - Kirsty McLean (Manchester Interdisciplinary Biocentre, UK)
Experimental probes of hydrogen tunnelling in enzyme systems
Nigel Scrutton (University of Manchester, UK)
11:00 - 11:30 Coffee/tea break
Mechanistic studies of oxidative halophenol dehalogenation by Heme-containing peroxidases
John Dawson (University of South Carolina, USA)
Hemoproteins: catalysts and sensors
Paul Ortiz de Montellano (University of California, San Francisco, USA)
13:50 - 16:00 Free Time and Boat trip on Lake Windermere
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Novel enzymes and processes
Chair:
Emma Raven (University of Leicester, UK)
Getting in a flap with DNA: how flap endonucleases achieve structure specific DNA cleavage
Jane Grasby (University of Sheffield, UK)
Structure and mechanism in cytochrome P450 redox systems
Andrew Munro (Manchester Interdisciplinary Biocentre, UK)
Thiamin biosynthesis - still yielding fascinating biological chemistry
Tadhg Begley (Cornell University, USA)
Advances in precision microvolume spectrophotometry and fluorescence spectroscopy
Bob Keighley (Varian Ltd, UK)
18:15 - 20:15 Conference Dinner
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Enzyme mechanism and chemical biology
Chair:
Paul Ortiz de Montellano (University of California, San Francisco, USA)
New approaches in enzymology
Chris Abell (University of Cambridge, UK)
Flavins: the winners and losers of B12 biosynthesis
Selected oral communication - Andrew Lawrence (University of Kent, UK)
How to interchange decarboxylase and oxidase activities with a single amino acid substitution
Selected oral communication - Stephen Bornemann (John Innes Centre, Norwich, UK)
Evolution of enzyme activity
Richard Pickersgill (Queen Mary, University of London, UK)
11:00 - 11:30 Coffee/tea break
Dynamics of domain movements and their role in force generation by myosin motors
Mike Geeves (University of Kent, UK)
How to BLUF ¿ insights into blue light signaling
Ilme Schlichting (Max Planck Institute, Heidelberg, Germany)
12:50 - 16:00 Lunch and free time
16:00 - 18:00 Poster session 2 (Posters P028-P055)
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Synthetic biology
Chair:
Richard Pickersgill (Queen Mary, University of London, UK)
Dissecting structure and mechanism of enzyme inhibition - practical lessons from drug discovery
Alan Wallace (AstraZeneca, Charnwood, UK)
Sugar and proteins: strategies in synthetic biology
Ben Davis (University of Oxford, UK)
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Structural and biophysical methods
Chair:
Martin Warren (University of Kent, UK)
The machine's smallest cog: unpaired electrons as probes of enzyme structure and function
Steve Rigby (Manchester Interdisciplinary Biocentre, UK)
Role of metals in E. coli copper amine oxidase
Michael McPherson (University of Leeds, UK)
C-H bond activation in heme proteins
Mike Green (Pennsylvania State University, USA)
11:00 - 11:30 Coffee/tea break
The DMGO-family, ¿simple¿ substrate channelling in a ¿primitive¿ enzyme?
David Leys (University of Manchester, UK)
Folding and unfolding by chaperone machines
Helen Saibil (Birkbeck College, University of London, UK)
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