Organizers:
Annette Dolphin (University College London, UK)
Jeff McIlhinney (MRC, Anatomical Neuropharmacology Unit, Oxford, UK)
Jeremy Henley (University of Bristol, UK)
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Session 1
Chair:
Annette Dolphin (University College London, UK)
Wednesday 10 September 2008
12:00 - 14:00 Registration and lunch
Potassium channel contribution to synaptic plasticity
Lily Yeh Jan (University of California, San Francisco, USA)
Nitric oxide is an activity-dependent modulator at the calyx of Held/MNTB synapse
Ian Forsythe (University of Leicester, UK)
15:20 - 15:40 Coffee/tea break
Structural and functional aspects of voltage-dependent ion channel signalling
Joel Hirsch (University of Tel Aviv, Israel)
Reciprocal alpha1-beta interactions are involved in membrane expression and synaptic targeting of calcium channels
Selected oral communication - Gerald Obermair (Innsbruck Medical University, Austria)
Trafficking of Kv4.2 channels and KChIP1 from the ER to the Golgi
Selected oral communication - Sarah Flowerdew (University of Liverpool, UK)
17:00 - 18:30 Drinks reception and poster session
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Session 2
Chair:
Angus Silver (University College London, UK)
Thursday 11 September 2008
Sculpting cell membranes: understanding pathways of endocytosis and exocytosis
Harvey McMahon (MRC-LMB, Cambridge, UK)
The transmitter release site organelle
Elise Stanley (University of Toronto, Canada)
Chronic exposure to lipids alters CaV distribution and inhibits insulin secretion
Selected oral communication - Michael Hoppa (Churchill Hospital, Oxford, UK)
11:10 - 11:40 Coffee/tea break
Shedding light on the assembly of synapse structure and function
Stephan Sigrist (European Neuroscience Institute, Germany)
Genetic dissection of the endocytic functions of the dynamins
Shawn Ferguson (Yale University, USA)
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Session 3
Chair:
Graham Collingridge (University of Bristol, UK)
Thursday 11 September 2008
Assembly and function of the presynaptic cytomatrix at active zone
Eckart Gundelfinger (Leibniz Institute for Neurobiology, Germany)
Timothy A. Ryan (Cornell University, USA)
Acute photoinactivation of clathrin heavy chain inhibits synaptic recycling but allows bulk membrane uptake upon stimulation
Selected oral communication - Jaroslaw Kasprowicz (Katholieke Universiteit Leuven, Belgium)
16:10 - 16:30 Coffee/tea break
A genetically-encoded reporter for imaging synaptic activity in vivo
Leon Lagnado (MRC-LMB, Cambridge, UK)
Synaptic AMPA receptor desensitization and neural computation
Angus Silver (University College London, UK)
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Session 4
Chair:
Ian Forsythe (University of Leicester, UK)
Regulating synaptic strength: integrins and homeostatic mechanisms
Yukiko Goda (LMCB, London, UK)
Unexpected features of neuronal signaling involving synapses and channels
Richard Tsien (Stanford University, USA)
10:20 - 10:40 Coffee/tea break
Single molecule tracking of glutamate receptor diffusion in and out synapses: a new function for AMPAR mobility in tuning fast synaptic transmission
Daniel Choquet (Institut François Magendie, France)
Efficient NR1/NR2 NMDA receptor cell surface trafficking is regulated by a functional ER quality control checkpoint, the integrity of the co-agonist glycine binding site
Selected oral communication - Anna Kenny (School of Pharmacy, University of London, UK)
Jeremy Henley (University of Bristol, UK)
12:20 - 13:20 Lunch and poster viewing
Memory and membrane dynamics in dendritic microdomains
Michael Ehlers - The Philip Godfrey Fund Memorial Lecture (Howard Hughes Medical Institute, USA)
Assembly of N-methyl-D-aspartate receptors
Jeff McIlhinney (University of Oxford, UK)
14:40 - 19:00 Free time (organised trip)
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Session 5
Chair:
Yukiko Goda (University College London, UK)
Saturday 13 September 2008
Ca2+-dependent release control at individual mossy fibre synapses
Dmitri Rusakov (University College London, UK)
Calcium channel regulation and short-term synaptic plasticity
William Catterall (University of Washington, USA)
Biophysical characterization of ion channels in the neocortex based on differential gene expression
Selected oral communication - Rajnish Ranjan (Brain Mind Institute, Switzerland)
10:40 - 11:00 Coffee/tea break
Role of N-terminal domain of GluR2 in spinogenesis
Maria Passafaro (Institute of Neuroscience, Italy)
Greater caliber dendrites have more spines and contain more microtubules as a subcellular supply route
Kristen Harris (University of Texas, USA)
Synergistic interactions between kainate and mGlu receptors in the induction of hippocampal mossy fibre LTP
Graham Collingridge (University of Bristol, UK)
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Session 6
Chair:
Jeremy Henley (University of Bristol, UK)
Saturday 13 September 2008
Genetic analysis of glutamate receptor signalling complexes reveals an evolutionarily conserved role for TARPs in synaptic transmission
Andres Villu Maricq (University of Utah, USA)
PTEN inhibition via leptin mediates subunit specific regulation of AMPA receptor trafficking
Selected oral communication - Peter Moult (University of Dundee, UK)
Synaptic calcium channels and migraine: enhanced glutamate release at cortical pyramidal cell synapses in a CaV2.1 hemiplegic migraine mouse model
Daniela Pietrobon (University of Padova, Italy)
16:10 - 16:30 Coffee/tea break
Calcium channel alpha2delta subunits, dysregulation in disease and therapeutic target
Annette Dolphin (University College London, UK)
The effect of familial hemiplegic migraine type 1 mutations on activation of migraine pathways: lessons from two FHM1 mouse models
Selected oral communication - Curtis Barrett (Leiden University Medical Centre, The Netherlands)
Translating ion channelopathy in epilepsy
Jeffrey Noebels (Baylor College of Medicine, USA)
18:10 - 19:00 Bar open/free time
19:00 - 21:00 Conference Dinner
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