Special Events
Stephen E. Halford (Bristol, UK)
Timetable
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Molecular Communications
Host colloquium
Organizers:
George Banting (Bristol)
Philip Godfrey Memorial Lecture
Role of atypical PKC in insulin action
Masato Kasuga (Department of Internal Medicine, Kobe, Japan)
Class-II PI 3-kinases: a new mechanism for participation of PI 3-kinase in growth factor signalling
Pete Shepherd (London, UK)
Signal transduction downstrean of PI 3-kinase
Dario Alessi (Dundee, UK)
10:30 - 11:30 Coffee Break
Richard Roth (Stanford, USA)
The regulation of GSK3 activity by insulin and other signals
Philip Cohen (Dundee, UK)
Regulation of glycogen synthesis in human muscle cells
Steve Yeaman (Newcastle, UK)
Role of PI3Ks and protein kinases in GLUT4 trafficking
Morrie Birnbaum (Philadelphia, USA)
Insulin regulation of GLUT4 translocation: A Tale of Two Signals
Jeff Pessin (Iowa College of Medicine, USA)
Biogenesis and trafficking of GSVs
16:00 - 18:00 Poster Session
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Molecular communications in membrane traffic pathways
Specificity in ligand binding and intracellular signalling by insulin and IGF receptors
Ken Siddle (Clinical Biochemistry, Cambridge, UK)
The regulation and mechanism of clathrin coated vesicle formation
Insulin receptor substrate proteins and neuroendocrine function
Dominic Withers (Imperial College, London, UK)
The role of COPI in vesicular transport
Tommy Nilsson (Heidelberg, Germany)
Morris White (Boston, USA)
AP-1 and GGAs: two adaptors for TGN to endosome trafficking
Scottie Robinson (Cambridge, UK)
Pathway of neuronal SNARE complex assembly
Dirk Fasshauer (Goettingen, Germany)
Functional effects of APS and SH2-B on insulin receptor signalling
Tahir Pillay (Nottingham, UK)
11:00 - 11:30 Coffee Break
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Spatiotemporal dynamics of lipid-based cell signalling
The role and regulation of phospholipase D in cellular stimulation
Michael Wakelam (Birmingham, UK)
Phosphoinositide 3-kinase gamma signalling: a structural perspective
Roger Williams (MRC-LMB, Cambridge UK)
Identification of phosphoinositide-binding proteins by using phosphoinositide-coupled affinity matrices
Phill Hawkins (Babraham Institute, Cambridge, UK)
Molecular determinants within pleckstrin homology (PH) domains that allow for specific recognition of phosphoinositides
Mark Lemmon (Pennsylvania, Philadelphia, USA)
16:00 - 18:00 Poster Session
Welcoming all delegates to the University of Bristol
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Protein:Protein communication
The biochemical properties of interactions between membrane proteins of leukocytes
Neil Barclay (Oxford, UK)
Structural biology of gamma-herpesvirus cyclins and how they subvert cyclin-dependent kinase inhibitor function
Mechanism of protein kinase inactivation by protein phosphatases
David Barford (London, UK)
10:30 - 11:00 Coffee Break
Stephen E. Halford (Bristol, UK)
Insights from the structure of the 30S ribosomal subunit and its complex with antibiotics
Venki Ramakrishnan (MRC, Cambridge)
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DNA/RNA:Protein communication
10:30 - 11:00 Coffee Break
Stephen E. Halford (Bristol, UK)
Suicidal proteins in E. coli
Colin Kleanthous (East Anglia, UK)
13:00 - 14:40 Lunch and Poster Session
Mechanism and regulation of transcription in Archaea
Stephen Bell (Wellcome/CRC Institute, UK)
HMG1and 2:architectural DNA-binding proteins
Jean Thomas (Cambridge, UK)
Coupled transcription in discrete 'factories' within mammalian nuclei
Peter R. Cook (Oxford, UK)
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Assembly and Repair of Membrane-Bound Electron Transport Complexes: Impact on Plant Physiology and Medicine
Bioenergetics Group colloquium
Organizers:
Peter Nixon (Imperial College, London)
Conrad Mullineaux (University College, London)
Redox signalling in chloroplasts and mitochondria: genomic and biochemical evidence for two-component regulatory systems in bioenergetic organelles
John Allen (Lund, Sweden)
Protein/RNA interaction in light regulated translation in the chloroplast
Steve Mayfield (Scripps, USA)
Can we identify the forces that drive the folding of integral membrane proteins?
Paula Booth (Bristol, UK)
The first green: assembly of quantum traps in higher plant plastids
Lutz Eichacker (Munchen, Germany)
11:00 - 11:30 Coffee Break
A role for molecular chaperones in assembly and repair of photosystem II?
Christoph Beck (Freiburg, Germany)
Identification of protease involved in the repair of photosystem II in Synechocystis 6803
Paulo Silva (Imperial College, London)
The role of the FtsH protease in the maintenance and assembly of photosynthetic reaction centres
Shaun Bailey (Warwick, UK)
Incorporation of iron-sulphur clusters into membrane-bound proteins
Andreas Seidler (Bochum, Germany)
16:00 - 18:00 Poster Session
Welcoming all delegates to the University of Bristol
Assembly-controlled regulation of chloroplast gene translation
Yves Choquet (Paris France)
Degradation of unassembled and damaged thylakoid proteins
Zach Adam (Rehovot, Israel)
The role of subunit III in the assembly of cytochrome oxidase in yeast
Brigitte Meunier (University College, London)
10:30 - 11:30 Coffee Break
Mitochondrial AAA proteases: control of biogenesis and maintenance of respiratory chain complexes
Thomas Langer (Muenchen, Germany)
Assembly of cytochrome c oxidase: implications for disease and ageing
Robert Poyton (Colorado, USA)
Impact of mitochondrial mutations on the assembly and activity of complex I in Chlamydomonas
Dr Claire Remacle (University of Liege, Belgium)
Assembly of cytochrome-c oxidase - what can we learn from the patients with cytochrome-c oxidase deficiency?
Jan-Willem Taanman (University College, London)
Chlamydomonas nuclear mutants that fail to assemble photosynthetic or respiratory electron transfer complexes
Saul Purton (University College, London)
16:00 - 18:00 Poster Session
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Membrane Active Peptides
Protein and Peptide Science Group colloquium
Organizers:
Brian Austen (London)
Parvez Haris (De Montfort)
De novo design, synthesis and characterization of membrane active peptides
Jim D. Lear (Philadelphia, USA)
Simulations studies of peptide/bilayer interactions
Peptaibols: models for ion channels
Bonnie Wallace (London, UK)
10:30 - 11:30 Coffee Break
Structural implications for the transformation of the Bacillus thuringiensis delta-endotoxins from water soluble to membrane inserted form
Developing structural models of K+ channels and their relatives based on analyses of distantly related sequences
H. Robert Guy (Bethesda, USA)
Insertion of transmembrane helices into the ER membrane
Gunnar von Heijne (Stockholm, Sweden)
Self-assembly of membrane protein monolayers on gold
Jeremy Lakey (Newcastle, UK)
Application of electron spin resonance for investigating peptide-lipid interactions
Derek Marsh (Gottingen, Germany)
Conformational analysis of synthetic potassium ion-channel peptides
Parvez I. Haris (Leicester, UK)
16:00 - 18:00 Poster Session
Binding of a signal sequence peptide: role of bilayer properties
Why and how are peptide-lipid interactions utilized for self-defence?
Katsumi Matsuzaki (Kyoto, Japan)
Membrane properties and amyloid fibril formation of lung surfactant protein C
Jan Johansson (Stockholm, Sweden)
10:30 - 11:00 Coffee Break
Stephen E. Halford (Bristol, UK)
Connexin mimetic peptides; specific inhibitors of gap junctional communication
W. Howard Evans (Cardiff, Wales)
Tethered bilayer lipid membranes as a support for membrane active peptides
Bruce Cornell (NSW, Australia)
13:00 - 14:40 Lunch and Poster Session
Membrane disordering effects of beta-amyloid peptides
Walter E. Mueller (Frankfurt, Germany)
Influenza fusion peptides
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Insulin Action
Regulation in Metabolism Group colloquium
Organizers:
Jeremy Tavaré (Bristol)
Sponsors:
GlaxoSmithKline
Phosphoinositide 3-kinase gamma signalling: a structural perspective
Roger Williams (MRC-LMB, Cambridge UK)
Identification of phosphoinositide-binding proteins by using phosphoinositide-coupled affinity matrices
Phill Hawkins (Babraham Institute, Cambridge, UK)
Molecular determinants within pleckstrin homology (PH) domains that allow for specific recognition of phosphoinositides
Mark Lemmon (Pennsylvania, Philadelphia, USA)
16:00 - 18:00 Poster Session
Welcoming all delegates to the University of Bristol
13:00 - 14:40 Lunch and Poster Session
Mechanism and regulation of transcription in Archaea
Stephen Bell (Wellcome/CRC Institute, UK)
HMG1and 2:architectural DNA-binding proteins
Jean Thomas (Cambridge, UK)
Coupled transcription in discrete 'factories' within mammalian nuclei
Peter R. Cook (Oxford, UK)
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Receptors and substrates
Specificity in ligand binding and intracellular signalling by insulin and IGF receptors
Ken Siddle (Clinical Biochemistry, Cambridge, UK)
The regulation and mechanism of clathrin coated vesicle formation
Insulin receptor substrate proteins and neuroendocrine function
Dominic Withers (Imperial College, London, UK)
The role of COPI in vesicular transport
Tommy Nilsson (Heidelberg, Germany)
Morris White (Boston, USA)
AP-1 and GGAs: two adaptors for TGN to endosome trafficking
Scottie Robinson (Cambridge, UK)
Pathway of neuronal SNARE complex assembly
Dirk Fasshauer (Goettingen, Germany)
Functional effects of APS and SH2-B on insulin receptor signalling
Tahir Pillay (Nottingham, UK)
11:00 - 11:30 Coffee Break
The role and regulation of phospholipase D in cellular stimulation
Michael Wakelam (Birmingham, UK)
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Lipid kinases and downstream regulation
Philip Godfrey Memorial Lecture
Role of atypical PKC in insulin action
Masato Kasuga (Department of Internal Medicine, Kobe, Japan)
Class-II PI 3-kinases: a new mechanism for participation of PI 3-kinase in growth factor signalling
Pete Shepherd (London, UK)
Signal transduction downstrean of PI 3-kinase
Dario Alessi (Dundee, UK)
10:30 - 11:30 Coffee Break
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Glycogen synthase and other targets
10:30 - 11:30 Coffee Break
Richard Roth (Stanford, USA)
The regulation of GSK3 activity by insulin and other signals
Philip Cohen (Dundee, UK)
Regulation of glycogen synthesis in human muscle cells
Steve Yeaman (Newcastle, UK)
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Glucose transport
Role of PI3Ks and protein kinases in GLUT4 trafficking
Morrie Birnbaum (Philadelphia, USA)
Insulin regulation of GLUT4 translocation: A Tale of Two Signals
Jeff Pessin (Iowa College of Medicine, USA)
Biogenesis and trafficking of GSVs
16:00 - 18:00 Poster Session
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Translation and protein synthesis
Insulin-stimulated phosphorylation of the translational regulator, 4E-BP1
Kate Heesom (Bristol, UK)
The biochemical properties of interactions between membrane proteins of leukocytes
Neil Barclay (Oxford, UK)
Interplay between insulin and nutrients in the regulation of protein synthesis
Structural biology of gamma-herpesvirus cyclins and how they subvert cyclin-dependent kinase inhibitor function
10:00 - 10:30 Selected Oral Presentations
Mechanism of protein kinase inactivation by protein phosphatases
David Barford (London, UK)
10:30 - 11:00 Coffee Break
Stephen E. Halford (Bristol, UK)
SREBP-1c, a mediator of insulin action on hepatic gene expression
Pascal Ferré (INSERM, Paris, France)
Insights from the structure of the 30S ribosomal subunit and its complex with antibiotics
Venki Ramakrishnan (MRC, Cambridge)
Suicidal proteins in E. coli
Colin Kleanthous (East Anglia, UK)
Insulin-regulated gene expression
Richard O'Brien (Vanderbilt, Nashville, USA)
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The Interface of Receptor Signalling and Trafficking
Membrane Group and Neuroscience Group colloquium
Organizers:
Craig McArdle (Bristol)
New insights into golgi function from 3-D structure and proteomics
Kathryn Howell (Denver, USA)
Molecular dissection of secretory granule biogenesis
Sharon Tooze (London, UK)
Control of membrane fusion dynamics during regulated exocytosis
Bob Burgoyne (Liverpool, UK)
10:30 - 11:30 Coffee Break
Disecting the functions of proteins in clathrin-coated vesicle formation
Harvey McMahon (Cambridge, UK)
Regulation of receptor trafficking and signalling by phosphatidylinositol 3-phosphate
Harald Stenmark (Oslo, Norway)
The relationship between endosomes and lysosomes
Paul Luzio (Cambridge, UK)
Internalization of the EGF receptor: role in signalling
Alexander Sorkin (Denver, USA)
Lipids and trafficking in neurons
Carlos Dotti (Heidelberg, Germany)
HRS Regulates Endosomal trafficking and tyrosine kinase receptor signalling
The role of phosphatidylinositol 3-kinases in sorting of EGF receptors within multivesicular endosomes
Regulation of EGF receptor traffic by RhoB
16:00 - 18:00 Poster Session
Proteins involved in the synaptic organisation of AMPA receptors
Jeremy Henley (Bristol, UK)
Beta-arrestin and GPCR internalization, desensitization and signalling (MAPK)
Stephane Laporte (Duke, USA)
Lysosmal degradation of the growth hormone receptor is regulated by the ubiquitin-proteasome pathway
Peter van Kerkhof (Utrecht, Netherlands)
10:30 - 11:00 Coffee Break
Stephen E. Halford (Bristol, UK)
Caveolins in Signaling, Oncogenic Transformation, and Muscular Dystrophy
Michael Lisanti (New York, USA)
Signalling and non-caveolar rafts
Justin Hsuan (London, Uk)
13:00 - 14:40 Lunch and Poster Session
Role of endocytosis in signaling and regulation of G protein-coupled receptors
Mark von Zastrow (San Fransisco,USA)
Multiple pathways of dynamin-regulated G protein-coupled receptor internalization
CJ van Koppen (Essen, Germany)
A role for receptor internalisation in muscarinic receptor association with ARF and activation of phospholipase D
Tethering proteins in ER-Golgi trafficking
Molecular communication across a membrane: spatial and temporal regulation of ER-to-Golgi transport
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Curriculum 2000: The Impact of Changes in Post-16 Curricula on University Biochemistry Teaching
Professional and Education Committee colloquium
Organizers:
Chris Skidmore (Reading)
Hilary Evans (Liverpool John Moores)
Curriculum 2000: the QCA view
David Mackay (Qualifications and Curriculum Authority)
Curriculum 2000: a teacher's view
Roger Barnes (St. Edmunds School, Canterbury)
Curriculum 2000: an Examination's Board's view
Curriculum 2000: an admissions tutor's view
16:00 - 18:00 Poster Session
16:20 - 17:00 Discussion followed by buffet and drinks
Welcoming all delegates to the University of Bristol
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Promega UK Young Life Scientist of the Year Award Final - 2001
Modelling and docking of the endothelin (ETA) G-protein coupled receptor
A.J.W. Orry - Biochemical Society Candidate
(Brikbeck College)
Somatostatin receptor subtype expression in human heart
William Smith - Biochemical Society Candidate
(University of Leeds)
Monitoring of CMV antigen specific T-cells
Geraldine Aubert - British Society for Histocompatibility and Immunogenetics Candidate
(Anthony Nolan Centre)
Evidence for a genetically stable clone of Campylobacter jejuni
Gina Manning - Society for General Microbiology Candidate
(Veterinary Laboratory Agency)
HSV-1 Latency in the central nervous system
Chris Smith - Society For General Microbiology Candidate
(University of Cambridge)
16:00 - 18:00 Poster Session
Amplifying DNA flanking an enhancer trap construct in Arabidopsis
Charles Hagen - The Genetics Society Candidate
(University of Exeter)
Difference in CD8+ T cell maturation according to viral specifity
Victor Appy - British Society for Immunology Candidate
(Institute of Molecular Medicine)
MAPKinase activation and chemotaxis induced by MCP-1, 2, 3 and 4 through the chemokine receptor CCR2b
Julie Wain - British Society for Immunology Candidate
(Newcastle Univeristy)
Welcoming all delegates to the University of Bristol
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