Special Events
Wellcome Trust Award for Research in Biochemistry Related to Medicine Lecture
Tony Kouzarides (Cambridge, UK)
Sir Frederick Gowland Hopkins Memorial Lecture
Edwin Southern (Oxford, UK)
Timetable
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Proteases and the Regulation of Biological Processes
Annual Symposium - in honour of Dr. Alan Barrett
Organizers:
Guy Salvesen (The Burnham Institute, San Diego, CA, USA)
Hideaki Nagase (Imperial College London, UK)
Jeremy Saklatvala (Imperial College London, UK)
Daiichi Fine Chemicals Co Ltd
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Bioinformatics, structure and function
Role of polyamine metabolism in neoplastic growth
Anthony Pegg (Hershey, PA, USA)
Wolfram Bode (Max-Planck-Institute, Munich, Germany)
Papain-like lysosomal cysteine proteases and their inhibitors:
drug discovery targets?
Dusan Turk (Jozef Stefan Institute, Ljubljana, Slovenia)
The role of polyamine catabolism in antitumor drug response
Robert Casero (Johns Hopkins, Baltimore, MD, USA)
Polyamine dependence of normal cell cycle progression
Stina Oredsson (Lund, Sweden)
Wellcome Trust Award for Research in Biochemistry Related to Medicine Lecture
Tony Kouzarides (Cambridge, UK)
Bcl-2 overexpression prevents the cytotoxic effects of the unsymmetrically substituted polyamine analogues in human leukaemic cells
Selected poster presentation - Alison Fraser (Aberdeen, UK)
Defective cell cycle progression in MCF-7 breast cancer cells treated with the spermine analogue N1,N11-diethylnorspermine
Selected poster presentation - Louise Myhre (Helgonavägen,
Lund, Sweden)
CYP1A1 genotype and colorectal cancer
Selected poster presentation - Nigel Brockton (Dundee, UK)
Gene expression analysis of mouse polyamine oxidase (PAOm)
Selected poster presentation - Paolo Mariottini (Università degli Studi di Roma Tre, Roma, Italy)
Acrolein produced from polyamines as one of the uremic toxins
Kasuei Igarashi (Chiba, Japan)
14:50 - 16:20 Tea and poster session
Role of polyamines in prostatic cancer
Raymond Schipper (Nijmegen, Netherlands)
Polyamines and colon cancer
Vladan Milovic (Frankfurt, Germany)
18:30 - 20:00 Drinks Reception in Main Dining Hall
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Proteasome and antigen presentation
Role of polyamine metabolism in neoplastic growth
Anthony Pegg (Hershey, PA, USA)
The role of polyamine catabolism in antitumor drug response
Robert Casero (Johns Hopkins, Baltimore, MD, USA)
Regulation of proteasome complexes
Jennifer Rivett (Bristol, UK)
Polyamine dependence of normal cell cycle progression
Stina Oredsson (Lund, Sweden)
Wellcome Trust Award for Research in Biochemistry Related to Medicine Lecture
Tony Kouzarides (Cambridge, UK)
Antigen processing in the endocytic compartment
Bcl-2 overexpression prevents the cytotoxic effects of the unsymmetrically substituted polyamine analogues in human leukaemic cells
Selected poster presentation - Alison Fraser (Aberdeen, UK)
Defective cell cycle progression in MCF-7 breast cancer cells treated with the spermine analogue N1,N11-diethylnorspermine
Selected poster presentation - Louise Myhre (Helgonavägen,
Lund, Sweden)
CYP1A1 genotype and colorectal cancer
Selected poster presentation - Nigel Brockton (Dundee, UK)
Gene expression analysis of mouse polyamine oxidase (PAOm)
Selected poster presentation - Paolo Mariottini (Università degli Studi di Roma Tre, Roma, Italy)
Acrolein produced from polyamines as one of the uremic toxins
Kasuei Igarashi (Chiba, Japan)
14:50 - 16:20 Tea and poster session
Role of polyamines in prostatic cancer
Raymond Schipper (Nijmegen, Netherlands)
Polyamines and colon cancer
Vladan Milovic (Frankfurt, Germany)
18:30 - 20:00 Drinks Reception in Main Dining Hall
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Extracellular and pericellular proteolysis
Role of polyamine metabolism in neoplastic growth
Anthony Pegg (Hershey, PA, USA)
The role of polyamine catabolism in antitumor drug response
Robert Casero (Johns Hopkins, Baltimore, MD, USA)
Polyamine dependence of normal cell cycle progression
Stina Oredsson (Lund, Sweden)
Wellcome Trust Award for Research in Biochemistry Related to Medicine Lecture
Tony Kouzarides (Cambridge, UK)
Bcl-2 overexpression prevents the cytotoxic effects of the unsymmetrically substituted polyamine analogues in human leukaemic cells
Selected poster presentation - Alison Fraser (Aberdeen, UK)
Defective cell cycle progression in MCF-7 breast cancer cells treated with the spermine analogue N1,N11-diethylnorspermine
Selected poster presentation - Louise Myhre (Helgonavägen,
Lund, Sweden)
CYP1A1 genotype and colorectal cancer
Selected poster presentation - Nigel Brockton (Dundee, UK)
Gene expression analysis of mouse polyamine oxidase (PAOm)
Selected poster presentation - Paolo Mariottini (Università degli Studi di Roma Tre, Roma, Italy)
Acrolein produced from polyamines as one of the uremic toxins
Kasuei Igarashi (Chiba, Japan)
Substrate specificity and inducibility of TACE revisited: the Ala-Val preference, and induced intrinsic activity
Roy Black (Immunex Corporation, USA)
14:50 - 16:20 Tea and poster session
Regulation of meprins at the cell surface
Judith Bond (Hershey, PA, USA)
Role of polyamines in prostatic cancer
Raymond Schipper (Nijmegen, Netherlands)
The role of TIMPs in pericellular proteolysis: the specificity is in the detail
Gillian Murphy (East Anglia, UK)
Polyamines and colon cancer
Vladan Milovic (Frankfurt, Germany)
Collagen-platelet interactions: recognition and signalling
Richard Farndale (Cambridge, UK)
18:30 - 20:00 Drinks Reception in Main Dining Hall
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Inflammation and tissue destruction
Polyamine reduced diet in metastatic hormone-refractory prostate cancer (HRPC) patients
Bernard Cipolla (Rennes, France)
Intracellular signals regulating proteinase production in inflammation
Jeremy Saklatvala (Imperial College, London, UK)
Polyamine analogues as potential anticancer agents
Heather Wallace (Aberdeen, UK)
Metalloproteases and cartilage degradation
John Mort (McGill, Montreal, Canada)
Polyamines as modifiers of genetic risk factors in human intestinal cancers
Eugene Gerner (Tucson, AZ, USA)
Cytokine synergy, collagenases and cartilage collagen breakdown
Tim Cawston (Newcastle Upon Tyne, UK)
Sir Frederick Gowland Hopkins Memorial Lecture
Edwin Southern (Oxford, UK)
Polyamines and novel polyamine conjugates interact with DNA in ways that can be exploited in non-viral gene therapy
Ian Blagbrough (Bath, UK)
The biological activities of new polyamine derivatives as potential therapeutic agents
14:50 - 16:20 Tea and poster session
Can cellular uptake of polyamines be exploited in drug delivery?
Paul Cullis (Leicester, UK)
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Proteinase inhibitors and potential for therapy
Polyamine reduced diet in metastatic hormone-refractory prostate cancer (HRPC) patients
Bernard Cipolla (Rennes, France)
Polyamine analogues as potential anticancer agents
Heather Wallace (Aberdeen, UK)
Polyamines as modifiers of genetic risk factors in human intestinal cancers
Eugene Gerner (Tucson, AZ, USA)
Sir Frederick Gowland Hopkins Memorial Lecture
Edwin Southern (Oxford, UK)
Polyamines and novel polyamine conjugates interact with DNA in ways that can be exploited in non-viral gene therapy
Ian Blagbrough (Bath, UK)
Protein oxidation, proteolysis and atherogenesis
Roger Dean (Heart Research Institute, Sydney, Australia)
Proteases as drug targets
Andy Docherty (Celltech Ltd., UK)
The biological activities of new polyamine derivatives as potential therapeutic agents
14:50 - 16:20 Tea and poster session
Can cellular uptake of polyamines be exploited in drug delivery?
Paul Cullis (Leicester, UK)
How serpins change their shape for better and for worse
Robin Carrell (Cambridge, UK)
Magnus Abrahamson (Lund, Sweden)
Engineering of selective TIMPs
Hideaki Nagase (Imperial College, London, UK)
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Processing
Wednesday 18 December 2002
Memapsin 2, a drug target for Alzheimer's disease
Jordan Tang (Oklahoma, USA)
Turnover of trypanosomal ornithine decarboxylases
Lo Persson (Lund, Sweden)
Polyamine biosynthetic enzymes as drug targets in parasitic protozoa
Regulation of lipid metabolism by proteolysis of SREBPs
Robert Rawson (Southwestern Medical Center, Dallas, TX, USA)
10:20 - 11:50 Coffee and poster session
Polyamine metabolism in microsporidia
Cy Bacchi (Pace, NY, USA)
Translational regulation of the plant S-adenosylmethionine decarboxylase
Anthony Michael (Institute of Food Research, Norwich, UK)
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Intracellular proteolysis and apoptosis
Wednesday 18 December 2002
Turnover of trypanosomal ornithine decarboxylases
Lo Persson (Lund, Sweden)
Polyamine biosynthetic enzymes as drug targets in parasitic protozoa
10:20 - 11:50 Coffee and poster session
Polyamine metabolism in microsporidia
Cy Bacchi (Pace, NY, USA)
A unified model of caspase activation
Guy Salvesen (The Burnham Institute, San Diego, CA, USA)
Translational regulation of the plant S-adenosylmethionine decarboxylase
Anthony Michael (Institute of Food Research, Norwich, UK)
The proteolytic mechanism of chromosome segregation
Frank Uhlmann (Cancer Research UK, London, UK)
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Proteolysis and cell migration
Wednesday 18 December 2002
Turnover of trypanosomal ornithine decarboxylases
Lo Persson (Lund, Sweden)
Polyamine biosynthetic enzymes as drug targets in parasitic protozoa
10:20 - 11:50 Coffee and poster session
Polyamine metabolism in microsporidia
Cy Bacchi (Pace, NY, USA)
Translational regulation of the plant S-adenosylmethionine decarboxylase
Anthony Michael (Institute of Food Research, Norwich, UK)
Membrane-type 1 MMP in cell migration
Motoharu Seiki (Tokyo, Japan)
Cathepsin B in malignant progression
Bonnie Sloane (Wayne State, MI, USA)
Proteolytic and non-proteolytic tumor cell migration
Peter Friedl (Wuerzburg, Germany)
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Polyamines and their Role in Human Disease
Organizer:
Heather Wallace (Aberdeen, UK)
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Polyamine metabolism and disease
Role of polyamine metabolism in neoplastic growth
Anthony Pegg (Hershey, PA, USA)
Wolfram Bode (Max-Planck-Institute, Munich, Germany)
Papain-like lysosomal cysteine proteases and their inhibitors:
drug discovery targets?
Dusan Turk (Jozef Stefan Institute, Ljubljana, Slovenia)
The role of polyamine catabolism in antitumor drug response
Robert Casero (Johns Hopkins, Baltimore, MD, USA)
Regulation of proteasome complexes
Jennifer Rivett (Bristol, UK)
Polyamine dependence of normal cell cycle progression
Stina Oredsson (Lund, Sweden)
Wellcome Trust Award for Research in Biochemistry Related to Medicine Lecture
Tony Kouzarides (Cambridge, UK)
Antigen processing in the endocytic compartment
Substrate specificity and inducibility of TACE revisited: the Ala-Val preference, and induced intrinsic activity
Roy Black (Immunex Corporation, USA)
14:50 - 16:20 Tea and poster session
Regulation of meprins at the cell surface
Judith Bond (Hershey, PA, USA)
The role of TIMPs in pericellular proteolysis: the specificity is in the detail
Gillian Murphy (East Anglia, UK)
Collagen-platelet interactions: recognition and signalling
Richard Farndale (Cambridge, UK)
18:30 - 20:00 Drinks Reception in Main Dining Hall
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Polyamines and cancer
Wolfram Bode (Max-Planck-Institute, Munich, Germany)
Papain-like lysosomal cysteine proteases and their inhibitors:
drug discovery targets?
Dusan Turk (Jozef Stefan Institute, Ljubljana, Slovenia)
Regulation of proteasome complexes
Jennifer Rivett (Bristol, UK)
Wellcome Trust Award for Research in Biochemistry Related to Medicine Lecture
Tony Kouzarides (Cambridge, UK)
Antigen processing in the endocytic compartment
Bcl-2 overexpression prevents the cytotoxic effects of the unsymmetrically substituted polyamine analogues in human leukaemic cells
Selected poster presentation - Alison Fraser (Aberdeen, UK)
Defective cell cycle progression in MCF-7 breast cancer cells treated with the spermine analogue N1,N11-diethylnorspermine
Selected poster presentation - Louise Myhre (Helgonavägen,
Lund, Sweden)
CYP1A1 genotype and colorectal cancer
Selected poster presentation - Nigel Brockton (Dundee, UK)
Gene expression analysis of mouse polyamine oxidase (PAOm)
Selected poster presentation - Paolo Mariottini (Università degli Studi di Roma Tre, Roma, Italy)
Acrolein produced from polyamines as one of the uremic toxins
Kasuei Igarashi (Chiba, Japan)
Substrate specificity and inducibility of TACE revisited: the Ala-Val preference, and induced intrinsic activity
Roy Black (Immunex Corporation, USA)
14:50 - 16:20 Tea and poster session
Regulation of meprins at the cell surface
Judith Bond (Hershey, PA, USA)
Role of polyamines in prostatic cancer
Raymond Schipper (Nijmegen, Netherlands)
The role of TIMPs in pericellular proteolysis: the specificity is in the detail
Gillian Murphy (East Anglia, UK)
Polyamines and colon cancer
Vladan Milovic (Frankfurt, Germany)
Collagen-platelet interactions: recognition and signalling
Richard Farndale (Cambridge, UK)
18:30 - 20:00 Drinks Reception in Main Dining Hall
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Polyamines and anticancer strategies
Polyamine reduced diet in metastatic hormone-refractory prostate cancer (HRPC) patients
Bernard Cipolla (Rennes, France)
Intracellular signals regulating proteinase production in inflammation
Jeremy Saklatvala (Imperial College, London, UK)
Polyamine analogues as potential anticancer agents
Heather Wallace (Aberdeen, UK)
Metalloproteases and cartilage degradation
John Mort (McGill, Montreal, Canada)
Polyamines as modifiers of genetic risk factors in human intestinal cancers
Eugene Gerner (Tucson, AZ, USA)
Cytokine synergy, collagenases and cartilage collagen breakdown
Tim Cawston (Newcastle Upon Tyne, UK)
Sir Frederick Gowland Hopkins Memorial Lecture
Edwin Southern (Oxford, UK)
Protein oxidation, proteolysis and atherogenesis
Roger Dean (Heart Research Institute, Sydney, Australia)
Proteases as drug targets
Andy Docherty (Celltech Ltd., UK)
14:50 - 16:20 Tea and poster session
How serpins change their shape for better and for worse
Robin Carrell (Cambridge, UK)
Magnus Abrahamson (Lund, Sweden)
Engineering of selective TIMPs
Hideaki Nagase (Imperial College, London, UK)
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Novel Inhibitors
Intracellular signals regulating proteinase production in inflammation
Jeremy Saklatvala (Imperial College, London, UK)
Metalloproteases and cartilage degradation
John Mort (McGill, Montreal, Canada)
Cytokine synergy, collagenases and cartilage collagen breakdown
Tim Cawston (Newcastle Upon Tyne, UK)
Sir Frederick Gowland Hopkins Memorial Lecture
Edwin Southern (Oxford, UK)
Polyamines and novel polyamine conjugates interact with DNA in ways that can be exploited in non-viral gene therapy
Ian Blagbrough (Bath, UK)
Protein oxidation, proteolysis and atherogenesis
Roger Dean (Heart Research Institute, Sydney, Australia)
Proteases as drug targets
Andy Docherty (Celltech Ltd., UK)
The biological activities of new polyamine derivatives as potential therapeutic agents
14:50 - 16:20 Tea and poster session
Can cellular uptake of polyamines be exploited in drug delivery?
Paul Cullis (Leicester, UK)
How serpins change their shape for better and for worse
Robin Carrell (Cambridge, UK)
Magnus Abrahamson (Lund, Sweden)
Engineering of selective TIMPs
Hideaki Nagase (Imperial College, London, UK)
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Polyamines and parasitic disease
Wednesday 18 December 2002
Turnover of trypanosomal ornithine decarboxylases
Lo Persson (Lund, Sweden)
Polyamine biosynthetic enzymes as drug targets in parasitic protozoa
10:20 - 11:50 Coffee and poster session
Polyamine metabolism in microsporidia
Cy Bacchi (Pace, NY, USA)
Translational regulation of the plant S-adenosylmethionine decarboxylase
Anthony Michael (Institute of Food Research, Norwich, UK)
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Sulphotransferases in Glycobiology
Host Colloquium
Glycobiology Group
Organizers:
Tony Corfield (Bristol, UK)
Jeremy Turnbull (Birmingham, UK)
Anne Dell (Imperial College London, UK)
Sulphation and lymphocyte homing
Steve Rosen (San Francisco, CA, USA)
Sulphotransferases acting on mucin type oligosaccharides
Inka Brockhausen (Kingston, Canada)
Glycoprotein hormone GalNAc-4-sulphotransferase
Jacques Baenziger (Washington University Medical School, St. Louis, MO, USA)
Wellcome Trust Award for Research in Biochemistry Related to Medicine Lecture
Tony Kouzarides (Cambridge, UK)
Structure and function of heparan sulphate N-deacetylase/N-sulphotransferase
Masahiko Negishi (NIH Research Triangle Park, NC, USA)
2-O-sulphate groups promote the catalytic activity of heparan sulphate 6-O-sulphotransferases
Selected poster presentation - Emanuel Smeds (Uppsala, Sweden)
Chondroitin and heparan sulphotransferases in the injured CNS: their role in the formation of the glial scar and in the inhibition of axon regrowth
Selected poster presentation - Francesca Properzi (Cambridge, UK)
Expression of heparan sulphate glucosaminyl 6-O-sulphotransferases in human kidney 293 cells
Selected poster presentation - Anh-Tri Do (Uppsala, Sweden)
Expression of heparan sulphate glucosaminyl 6-O-sulphotransferases in human kidney 293 cells
Selected poster presentation - Anh-Tri Do (Uppsala, Sweden)
Glial cell line-derived neurotrophic factor (GDNF) binds to heparin with a particular dependence on 2-O-sulphates
Selected poster presentation - Christopher Rider (Royal Holloway, London, UK)
14:50 - 16:20 Tea and poster session
Sulphation patterns in heparan sulphate
John Gallagher (Manchester, UK)
NDSTs in heparan sulphate biosynthesis and biology
Lena Kjellen (Uppsala, Sweden)
Heparan sulphate sulphotransferase expression in mice and C elegans
Jeremy Turnbull (Birmingham, UK)
18:30 - 20:00 Drinks Reception in Main Dining Hall
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Proteasome Interactions with Viral and Cellular Proteins
Regulation in Metabolism Group
Organizers:
Jenny Rivett (Bristol, UK)
Martin Allday (Imperial, UK)
An interaction map of proteasome subunits
Olivier Coux (CRBM-CNRS, Montpellier, France)
Proteasomal interactors control activities as diverse as the cell cycle and glutaminergic neurotransmission
R. John Mayer (Nottingham, UK)
Inhibition of MHC class I antigen presentation by a viral ubiquitin E3-ligase
Selected poster presentation - Paul Lehner (Cambridge Institute for Medical Research, UK)
Interactions between Epstein-Barr Virus (EBV) nuclear antigens and the proteasome
Selected poster presentation - Jude Heaney (Imperial College London, UK)
Sir Frederick Gowland Hopkins Memorial Lecture
Edwin Southern (Oxford, UK)
Ubiquitin-mediated proteolysis: at the crossroads of apoptosis
Aaron Ciechanover (Technion-Israel Institute of Technology, Haifa, Israel)
Regulation of the ubiquitin-proteasome system in virus infected and tumor cells
Maria Masucci (Karolinska Institute, Stockholm, Sweden)
14:50 - 16:20 Tea and poster session
Protecting the p53 tumour suppressor from degradation
HPV E6 activation of SRC family kinases
Peter Howley (Harvard Medical School, MA, USA)
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Human Ageing: From the Bench to the Clinic
Biochemical Society and the British Society for Research on Ageing
Organizers:
Janet Lord (Birmingham,UK)
Richard Aspinall (Imperial, UK)
Yvonne Barnett (Coleraine, UK)
Cellular senescence and ageing phenotypes
Judith Campisi (Berkeley, CA, USA)
A study of mitochondrial DNA mutations in peripheral lymphocytes in an ageing cohort
Selected Poster Presentation - Beatrice Baiping Zhang (Southampton, UK)
Age effects on antibody affinity maturation
Selected Poster Presentation - Deborah Dunn-Walters (Guy's Hospital, London, UK)
Neutrophil superoxide generation and phagocytosis are reduced in elderly trauma patients: relation to increased infection rates
Selected Poster Presentation - Stephen Butcher (Birmingham, UK)
A critique of the demographic evidence that the oldest oldflies and humans age very slowly
Selected Poster Presentation - Aubrey de Grey (Cambridge, UK)
Skeletal muscles of aged male mice fail to adapt following contractile activity
Selected Poster Presentation - Aphrodite Vasilaki (Liverpool, UK)
Wellcome Trust Award for Research in Biochemistry Related to Medicine Lecture
Tony Kouzarides (Cambridge, UK)
Centenarians as models for healthy ageing
Claudio Francheschi (Bologna, Italy)
Exercise models of ageing and possible intervention strategies
Jonathan Powell (Unilever, UK)
14:50 - 16:20 Tea and poster session
Osteoporosis and clinical intervention
Graham Russell (Oxford, UK)
Nutritional approaches to delaying ageing
Kay-Tee Khaw (Cambridge, UK)
18:30 - 20:00 Drinks Reception in Main Dining Hall
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Drug Discovery and Design
Industrial Biochemistry and Biotechnology Group
Organizers:
Diane Kelly (Aberystwyth, UK)
Genomics in target and drug discovery
Marcel van Duin (Organon Laboratories Ltd., Lanarkshire, UK)
Gene chip technology and the use of expression arrays in drug discovery programs
Eric Schadt (Merck & Co. Inc., USA)
The use of I.T. in discovery of new therapeutics
Scott Kahn (Accelrys Ltd., Cambridge, UK)
Sir Frederick Gowland Hopkins Memorial Lecture
Edwin Southern (Oxford, UK)
Connecting drug, target and network
Adele Rowley (Cellzome, Elstree, UK)
Structure based drug discovery
Adrian Gill (Astex Technology Ltd., UK)
14:50 - 16:20 Tea and poster session
The role of therapeutic antibodies in drug discovery
Steven Holmes (Oxford Glycosciences (UK) Ltd., UK)
The future of drug discovery
Malcolm Weir (Inpharmatica Ltd, London, UK)
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Research Colloquium - Biological Functions of Sulphated Glycoproteins
Inflammation, heparin, and endothelial heparan sulphate
Invited Speaker - Jeff Esko (San Diego, CA, USA)
Role of heparan sulphate domain organisation in endostatin action
Maarten Vanwildemeersch (Uppsala, Sweden)
Differential modulation of TSG-6 function by heparin
David Mahoney (Oxford, UK)
A gravimetric analysis of protein-oligosaccharide interactions
Molecular recognition and modulation of hepatocyte growth factor activity by heparan and dermatan sulphates
Krista Catlow (Paterson Institute for Cancer Research, Manchester, UK)
Sir Frederick Gowland Hopkins Memorial Lecture
Edwin Southern (Oxford, UK)
Promega UK Young Biochemist 2002
Interactions between vascular endothelial growth factor 165 and heparan sulphate
Chris Robinson (Patterson Institute for Cancer Research, Manchester, UK)
Endothelial heparan sulphate proteoglycans bind IL-8 in the rheumatoid synovium
Angela Patterson (RJAH Orthopaedic Hospital, Owestry, UK)
14:50 - 16:20 Tea and poster session
Localisation of heparan sulphate 6-O-sulphotransferases 1,2 and 3 in the developing mouse brain
Katherine Drummond (Birmingham, UK)
Signalling through a cell surface proteoglycan
Invited Speaker - John Couchman (Imperial College, London)
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