Special Events
Linking endocytic cargo to clathrin : structural and functional insights into coated vesicle formation
Dr David Owen (CIMR, Cambridge, UK)
Modular proteins at the cell surface
Professor Iain Campbell (Oxford, UK)
The molecular machinery of Keilin's respiratory chain
Professor Peter Rich (University College London, UK)
Timetable
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Annual Symposium - Free Radicals: Enzymology, Signalling and Disease
Organizers:
Mike Wilson (Essex, UK)
Victor Darley-Usmar (Birmingham, AL, USA)
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Radical Enzymology
Metal/radical enzymes - an overview
Andy Thomson (Norwich, UK)
Cofactor processing in galactose oxidase
Mike McPherson (Leeds, UK)
Pascal Ferré and Mike Titheradge
Mechanisms of evolution of ribonucleotide reductases
Britt-Marie Sjoberg (Stockholm, Sweden)
The glucose-fatty acid cycle: a physiological perspective
11:00 - 11:30 Coffee/Tea Break
Linking endocytic cargo to clathrin : structural and functional insights into coated vesicle formation
Dr David Owen (CIMR, Cambridge, UK)
12:20 - 14:00 Lunch and Poster Session
Molecular mechanisms regulating hormone-sensitive lipase and lipolysis
Cecilia Holm (Lund, Sweden)
Defining substrate specificity and catalytic mechanism in ascorbate peroxidase
Emma Raven (Leicester, UK)
Fatty acid recycling in adipocytes: a role for glyceroneogenesis and phosphoenolpyruvate carboxykinase
Claude Forest (Paris, France)
Flavin radicals and electron transfer
Nigel Scrutton (Leicester, UK)
15:20 - 15:50 Coffee/Tea Break
Protein radicals in cytochrome c oxidase - tyrosine or tryptophan?
Dimitri Svistunenko (Essex, UK)
Roles of peroxisome proliferator delta in the control of muscle development and metabolism
Paul Grimaldi (Institute de Signalisation, Nice, France)
Activation of cytochrome c to a peroxidase compound I-type intermediate by H2O2: Relevance to redox signalling in apoptosis
Selected Poster Presentation - Mark Burkitt (Gray Cancer Institute, Northwood, UK)
Tyrosine nitration of muscle carnitine palmitoyl transferase I in sepsis
Simon Eaton (Institute of Child Health, London, UK)
Iron chelators reduce ferryl myoglobin and inhibit cytotoxic haem-to-protein cross-linking
Selected Poster Presentation - Brandon Reeder (Essex, UK)
The TIBS Lecture - Radical reactions of nitric oxide synthases
Dennis Stuehr (Lerner Research Institute, Cleveland, OH, USA)
18:00 - 19:30 Welcome Drinks Reception
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Radical Disease
Mitochondrial superoxide and aging
Martin Brand (Cambridge, UK)
SOD activity of prion proteins
Clinical aspects of reactive oxygen and nitrogen species biology
Thomas Munzel (Hamburg, Germany)
10:50 - 11:20 Coffee/Tea Break
Modular proteins at the cell surface
Professor Iain Campbell (Oxford, UK)
Modulation of the L-arginine-nitric oxide signalling pathway in the vasculature
Giovanni Mann (King's College London, UK)
Biological role of haem oxygenase-1 in response to oxidative and nitrosative stress
Roberto Motterlini (Imperial College London, UK)
14:30 - 15:00 Coffee/Tea Break
The molecular machinery of Keilin's respiratory chain
Professor Peter Rich (University College London, UK)
Role of S-nitrosohemoglobin in vascular dysfunction associated with Sepsis
Selected Poster Presentation - Rakesh Patel (Birmingham, AL, USA)
Proteomics analysis of cellular responses in drosophila melanogaster to oxidative stress
Selected Poster Presentation - Joanne Mathers (Dundee,UK)
Haem proteins, radicals and oxidative stress
Kevin Moore (Royal Free Hospital London, UK)
17:30 - 19:00 Drinks and Poster Session
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Radical Signalling
11:00 - 11:30 Coffee/Tea Break
The WPI Lecture - Radical signalling; from NO in mitochondria to oxidized lipids
Victor Darley-Usmar (Birmingham, AL, USA)
12:50 - 14:15 Lunch and Poster Session
Nitric oxide activation of guanylate cyclase
Doris Koesling (Bochum, Germany)
Superoxide and peroxide signalling
Dave Lambeth (Emory, GA, USA)
Nitric oxide signalling: insect brains and photocytes
Barry Trimmer (Medford, MA, USA)
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Protein Synthesis and Quality Control at the Endoplasmic Reticulum
Membrane Group
Organizers:
Stephen High (Manchester, UK)
Neil Bulleid (Manchester, UK)
Nascent chain control of ribosome and translocon structure and function
Art Johnson (Texas A & M, TX, USA)
Regulation of protein targeting to the endoplasmic reticulum
Martin Pool (Manchester, UK)
Sss1p recruits Sec63p to the translocon and is required to initiate translocation of the secretory precursors bound to Sec61p
Colin Stirling (Manchester, UK)
10:50 - 11:20 Coffee/Tea Break
Modular proteins at the cell surface
Professor Iain Campbell (Oxford, UK)
Biogenesis of C tail-anchored proteins
Nica Borgese (Milan, Italy)
Intramembrane proteolysis and post-targeting functions of signal peptides
Bruno Martoglio (ETH, Zurich, Switzerland)
14:30 - 15:00 Coffee/Tea Break
The molecular machinery of Keilin's respiratory chain
Professor Peter Rich (University College London, UK)
Membrane protein biosynthesis at the ER
Stephen High (Manchester, UK)
Dissecting the roles of Sec63p in protein translocation
Selected Poster Presentation - Andy Jermy (Manchester, UK)
17:30 - 19:00 Drinks and Poster Session
Organization of translocon complexes in the ER membrane
Gert Kreibich (New York, NY, USA)
GPI - anchored membrane protein biosynthesis
Neil Bulleid (Manchester, UK)
11:00 - 11:30 Coffee/Tea Break
Pathways for disulfide bond formation living cells
Chris Kaiser (MIT, Cambridge, MA, USA)
Glycoprotein folding in the ER lumen
Ari Helenius (ETH, Zurich, Switzerland)
12:50 - 14:15 Lunch and Poster Session
Retrograde transport of toxins across the ER membrane
Protein quality control and autosomal dominant retinitis pimentosa
Ron Kopito (Stanford, CA, USA)
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Integration of Mitogenic and Migratory Signals from G-Protein-Coupled Receptors and Tyrosine Kinases
Hormone Group
Organizer:
Tim Palmer (Glasgow, UK)
12:20 - 14:00 Lunch and Poster Session
VEGF receptor signaling and its integrating role in endothelial biology
Ian Zachary (University College London, UK)
Receptor tyrosine kinase signalling and endocytosis
Ivan Dikic (Goethe University Medical School, Frankfurt, Germany)
15:20 - 15:50 Coffee/Tea Break
G-protein coupled receptor anti-apoptotic response
Andrew Tobin (Leicester, UK)
Erk2 docking and phosphorylation of PDE4 cAMP phosphodiesterases isoforms
in the control of cAMP signalling
Miles D. Houslay (Glasgow, UK)
Protease-regulated signalling by G-protein coupled receptors (GPCRs)
Nigel Bunnett (San Francisco, CA, USA)
18:00 - 19:30 Welcome Drinks Reception
Metalloprotease-dependent ErbB ligand shedding in mediating EGFR transactivation and vascular remodeling
Satoru Eguchi (Vanderbilt, TN, USA)
EGFR transactivation in cancer cells
Oliver Fischer (Martinsried, Germany)
10:50 - 11:20 Coffee/Tea Break
Modular proteins at the cell surface
Professor Iain Campbell (Oxford, UK)
Lysophosphatidic acid, mitogen and motility factor
Frank van Leeuwen (Amsterdam, The Netherlands)
Stress-induced ATP release and growth modulation of human lens and retinal pigment epithelial cells
Selected Poster Presentation - Julie Eldred (East Anglia, UK)
14:30 - 15:00 Coffee/Tea Break
The molecular machinery of Keilin's respiratory chain
Professor Peter Rich (University College London, UK)
The many hues of sphingosine-1-phosphate
Sarah Spiegel (Richmond, VA, USA)
Receptor tyrosine kinase-GPCR signal complexes
Nigel Pyne (Strathclyde, UK)
17:30 - 19:00 Drinks and Poster Session
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Superoxide: Production and Destruction
Bioenergetics Group
Organizers:
Martin Brand (Cambridge, UK)
John Moody (Plymouth, UK)
Mitochondrial targetted antioxidants
Mike Murphy (Cambridge, UK)
Mitochondrial matrix ROS production is very sensitive to mild uncoupling
Selected Poster Presentation - Satomi Miwa (Cambridge, UK)
Novel SOD and catalase mimics for the treatment of inflammatory diseases
Selected Poster Presentation - Declan Naughton (Brighton, UK)
Use of SOD/catalase mimetics to extend lifespan
Matthew Gill (Buck Institute for Age Research, Novato, CA, USA)
11:00 - 11:30 Coffee/Tea Break
Linking endocytic cargo to clathrin : structural and functional insights into coated vesicle formation
Dr David Owen (CIMR, Cambridge, UK)
12:20 - 14:00 Lunch and Poster Session
Antioxidants as treatments for mitochondrial diseases
Tony Shapira (Royal Free Hospital London, UK)
Mechanisms of the development of diabetic complications
Michael Brownlee - sponsored by Woerwag Pharma (Albert Einstein College of Medicine, NY, USA)
15:20 - 15:50 Coffee/Tea Break
Does mitochondrial superoxide production occur in the living cell?
Hans Nohl (Vienna, Austria)
Cytochrome c, ideal antioxidant
Vladimir Skulachev (Moscow, Russia)
Inhibition of UCP3 causes mitochondrial oxidative damage
Selected Poster Presentation - Darren Talbot (Cambridge, UK)
Control of superoxide production in cauliflower mitochondria
Selected Poster Presentation - Vasily Popov (Voronezh State, Russia)
18:00 - 19:30 Welcome Drinks Reception
Mitochondrial superoxide and aging
Martin Brand (Cambridge, UK)
SOD activity of prion proteins
The irony of manganese superoxide dismutase
James Whittaker (Beaverton, OR, USA)
10:50 - 11:20 Coffee/Tea Break
Modular proteins at the cell surface
Professor Iain Campbell (Oxford, UK)
Prokaryotic copper/zinc superoxide dismutase
Alessandro Desideri (Rome, Italy)
Role of prokaryotic Cu/Zn superoxide dismutase in pathogenesis
Andrea Battistoni (Rome, Italy)
14:30 - 15:00 Coffee/Tea Break
The molecular machinery of Keilin's respiratory chain
Professor Peter Rich (University College London, UK)
Iron superoxide dismutase: structure and function of an archaic enzyme
Günter Schäfer (Institute für Biochemie, Lübeck, Germany)
Reduction of one-electron acceptors by cellobiose oxidoreductase
Selected Poster Presentation - Maria Mason (Essex, UK)
Kinetics of superoxide scavenging by glutathione: an evaluation of its role in the removal of mitochondrial superoxide
Selected Poster Presentation - Clare Jones (Gray Cancer Institute, Northwood, UK)
17:30 - 19:00 Drinks and Poster Session
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The Glucose/Fatty Acid Cycle 1963-2003: A Tribute to Sir Philip Randle
Regulation in Metabolism Group
Organizers:
Mike Titheradge (Sussex, UK)
Pascal Ferré (INSERM, Paris, France)
Institut de Recherches Servier
11:00 - 11:30 Coffee/Tea Break
The WPI Lecture - Radical signalling; from NO in mitochondria to oxidized lipids
Victor Darley-Usmar (Birmingham, AL, USA)
12:50 - 14:15 Lunch and Poster Session
Nitric oxide activation of guanylate cyclase
Doris Koesling (Bochum, Germany)
Superoxide and peroxide signalling
Dave Lambeth (Emory, GA, USA)
Nitric oxide signalling: insect brains and photocytes
Barry Trimmer (Medford, MA, USA)
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Overview
Metal/radical enzymes - an overview
Andy Thomson (Norwich, UK)
Cofactor processing in galactose oxidase
Mike McPherson (Leeds, UK)
Pascal Ferré and Mike Titheradge
Mechanisms of evolution of ribonucleotide reductases
Britt-Marie Sjoberg (Stockholm, Sweden)
The glucose-fatty acid cycle: a physiological perspective
11:00 - 11:30 Coffee/Tea Break
Linking endocytic cargo to clathrin : structural and functional insights into coated vesicle formation
Dr David Owen (CIMR, Cambridge, UK)
12:20 - 14:00 Lunch and Poster Session
Defining substrate specificity and catalytic mechanism in ascorbate peroxidase
Emma Raven (Leicester, UK)
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Fatty Acid Release by Adipose Tissue
12:20 - 14:00 Lunch and Poster Session
Molecular mechanisms regulating hormone-sensitive lipase and lipolysis
Cecilia Holm (Lund, Sweden)
Defining substrate specificity and catalytic mechanism in ascorbate peroxidase
Emma Raven (Leicester, UK)
Fatty acid recycling in adipocytes: a role for glyceroneogenesis and phosphoenolpyruvate carboxykinase
Claude Forest (Paris, France)
Flavin radicals and electron transfer
Nigel Scrutton (Leicester, UK)
15:20 - 15:50 Coffee/Tea Break
Protein radicals in cytochrome c oxidase - tyrosine or tryptophan?
Dimitri Svistunenko (Essex, UK)
The TIBS Lecture - Radical reactions of nitric oxide synthases
Dennis Stuehr (Lerner Research Institute, Cleveland, OH, USA)
SCHAD deficiency associated with hyperinsulinism: a novel glucose-fatty acid cycle?
Selected Poster Presentation - Simon Eaton (Institute of Child Health, London, UK)
Identification of adipocyte glyceroneogenesis as a major target for the hypolipidemic action of thiazolidinediones
Selected Poster Presentation - Bénédicte Antoine (Inserm-Université René Descartes, Paris, France)
Mechanism of glucose sensing in the small intestine
Selected Poster Presentation - Jane Dyer (Liverpool, UK)
18:00 - 19:30 Welcome Drinks Reception
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Fatty Acid Uptake and Oxidation in Muscle
12:20 - 14:00 Lunch and Poster Session
Defining substrate specificity and catalytic mechanism in ascorbate peroxidase
Emma Raven (Leicester, UK)
Flavin radicals and electron transfer
Nigel Scrutton (Leicester, UK)
15:20 - 15:50 Coffee/Tea Break
Protein radicals in cytochrome c oxidase - tyrosine or tryptophan?
Dimitri Svistunenko (Essex, UK)
Roles of peroxisome proliferator delta in the control of muscle development and metabolism
Paul Grimaldi (Institute de Signalisation, Nice, France)
Tyrosine nitration of muscle carnitine palmitoyl transferase I in sepsis
Simon Eaton (Institute of Child Health, London, UK)
The TIBS Lecture - Radical reactions of nitric oxide synthases
Dennis Stuehr (Lerner Research Institute, Cleveland, OH, USA)
SCHAD deficiency associated with hyperinsulinism: a novel glucose-fatty acid cycle?
Selected Poster Presentation - Simon Eaton (Institute of Child Health, London, UK)
Identification of adipocyte glyceroneogenesis as a major target for the hypolipidemic action of thiazolidinediones
Selected Poster Presentation - Bénédicte Antoine (Inserm-Université René Descartes, Paris, France)
Mechanism of glucose sensing in the small intestine
Selected Poster Presentation - Jane Dyer (Liverpool, UK)
18:00 - 19:30 Welcome Drinks Reception
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Biochemical Basis for the Glucose/Fatty Acid Cycle
Mitochondrial superoxide and aging
Martin Brand (Cambridge, UK)
Regulation of pyruvate dehydrogenase activity by reversible phosphorylation
SOD activity of prion proteins
Phosphofructokinases-hexokinase
Louis Hue (Brussels, Belguim)
Clinical aspects of reactive oxygen and nitrogen species biology
Thomas Munzel (Hamburg, Germany)
10:50 - 11:20 Coffee/Tea Break
Modular proteins at the cell surface
Professor Iain Campbell (Oxford, UK)
Modulation of the L-arginine-nitric oxide signalling pathway in the vasculature
Giovanni Mann (King's College London, UK)
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Physiopathological and New Aspects of the Glucose/Fatty Acid Cycle
Mitochondrial superoxide and aging
Martin Brand (Cambridge, UK)
SOD activity of prion proteins
Clinical aspects of reactive oxygen and nitrogen species biology
Thomas Munzel (Hamburg, Germany)
Fatty acids, insulin resistance and glucose transport
Yannick Le Marchand-Brustel (Nice, France)
10:50 - 11:20 Coffee/Tea Break
Modular proteins at the cell surface
Professor Iain Campbell (Oxford, UK)
Modulation of the L-arginine-nitric oxide signalling pathway in the vasculature
Giovanni Mann (King's College London, UK)
Molecular mechanisms in human insulin resistance
Stephen O'Rahilly (Cambridge, UK)
Bypassing the glucose fatty acid cycle: AMP-activated protein kinase
David Carling (Imperial College London, UK)
Biological role of haem oxygenase-1 in response to oxidative and nitrosative stress
Roberto Motterlini (Imperial College London, UK)
14:30 - 15:00 Coffee/Tea Break
The molecular machinery of Keilin's respiratory chain
Professor Peter Rich (University College London, UK)
Extending the glucose-fatty acid cycle: a glucose-adipose tissue cycle
Michèle Guerre-Millo (Paris, France)
Haem proteins, radicals and oxidative stress
Kevin Moore (Royal Free Hospital London, UK)
AZD7545, a novel inhibitor of PDHK2, activates PDH in vivo and improves blood glucose control in obese (fa/fa) Zucker rats
Selected Poster Presentation - Rachel Mayers (AstraZeneca, UK)
AZD7545 is a Selective Inhibitor of Pyruvate Dehydrogenase Kinase2
Selected Poster Presentation - Jenny Morrell (AstraZeneca, UK)
17:30 - 19:00 Drinks and Poster Session
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Exercise Metabolism: Nutrition, Substrate Utilization and Regulation
Organizers:
Gareth Jones (Essex, UK)
Jeremy Shearman (Essex, UK)
Experiment and computer aided simulation as tools to understand exercise metabolism
Nutritional status, metabolic responses to exercise and implications for performance
Ronald Maughan (Aberdeen, UK)
11:00 - 11:30 Coffee/Tea Break
Modulation of carbohydrate and fat utilization by diet, exercise and environment
Asker Jeukendrup (Birmingham, UK)
Regulation of PDH activity, isoform expression, diet and exercise
Sandra Peters (Brock, Ontario, Canada)
12:50 - 14:15 Lunch and Poster Session
Insulin signalling, exercise and cellular integrity
John Kirwan (Case Western Reserve, OH, USA)
The genetics of human physical performance
Hugh Montgomery (Royal Free and University College London, UK)
Trangenic models- Scientific tool to understand exercise induced metabolism
Jorgen Wojtaszewski (Copenhagen, Denmark)
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The Enzymatic Defence against Glycation in Health, Disease and Therapeutics
Organizer:
Paul Thornalley (Essex, UK)
Sponsors:
Cancer Research UK
Fresenius Medical Care AG, Germany
Dynamis Therapeutics Inc., USA
Functional plasticity of the protein folds of glyoxalases and glutathione transferases
Bengt Mannervik (Uppsala, Sweden)
Amadoriase enzymes: structure function studies
Vincent Monnier (Cleveland, OH, USA)
Fructosamine 3-kinase: an enzyme involved in protein deglycation
Ghislain Delpierre (Louvain, Belgium)
11:00 - 11:30 Coffee/Tea Break
Linking endocytic cargo to clathrin : structural and functional insights into coated vesicle formation
Dr David Owen (CIMR, Cambridge, UK)
12:20 - 14:00 Lunch and Poster Session
Aldose reductase and the importance of experimental design
James Crabbe (Reading, UK)
Mechanisms of the development of diabetic complications
Michael Brownlee - sponsored by Woerwag Pharma (Albert Einstein College of Medicine, NY, USA)
15:20 - 15:50 Coffee/Tea Break
 -oxoaldehyde metabolism and diabetic complications
Paul Beisswenger (Dartmouth Medical School, Hanover, NH, USA)
Therapeutic potential of fructosamine 3-phosphokinase inhibitors
Truman Brown (Dynamis Therapeutics Inc. and Columbia, NY, USA)
Physiological function of RAGE?
Selected Poster Presentation - Angelika Bierhaus (Heidelberg, Germany)
Relationship between genetic polymorphism of antioxidant enzyme and diabetic complications
Selected Poster Presentation - Katerina Kankova (Masaryk University Brno, Czech Republic)
18:00 - 19:30 Welcome Drinks Reception
Protecting the genome: defence against nucleotide glycation and emerging role in multidrug resistance in cancer chemotherapy
Paul Thornalley (Essex, UK)
The Cancer Research Lecture - Glyoxalase I inhibitors in cancer chemotherapy
Don Creighton (Baltimore, MD, USA)
Intake of exogenous AGEs: glycation in food and metabolic transit
Thomas Henle (Dresden, Germany)
10:50 - 11:20 Coffee/Tea Break
Modular proteins at the cell surface
Professor Iain Campbell (Oxford, UK)
Renal clearance of glycation adducts: anti-glycation defence in uraemia and dialysis
Anne Dawnay (University College London Hospitals, UK)
Glyoxal , oxidative stress and thiamine deficiency induced colon cancer
Selected Poster Presentation - Nandita Shangari (Toronto, ON, Canada)
Removal of advanced glycation end products in clinical renal failure by peritoneal dialysis and haemodialysis
Selected Poster Presentation - Stamatina Agalou (Essex, UK)
14:30 - 15:00 Coffee/Tea Break
The molecular machinery of Keilin's respiratory chain
Professor Peter Rich (University College London, UK)
Anti-glycation defences in Alzheimer¿s disease
Gerald Munch (Leipzig, Germany)
The role of glyoxalase-1 inhibition on endothelial cell activation
Selected Poster presentation - Meriem Bourajjaj (Institute for Cardiovascular Research ¿Vrije Universiteit, Amsterdam, The Netherlands.)
Tissue protein modification by advanced Maillard adducts can be modulated by dietary polyunsaturated fatty acids
Selected Poster Presentation - Manuel Portero-Otin (Lleida, Spain)
17:30 - 19:00 Drinks and Poster Session
Methylglyoxal production in bacteria: suicide or survival?
The anti-glycation defences in yeast
Ana Ponces-Freire (Lisbon, Portugal)
11:00 - 11:30 Coffee/Tea Break
Pyridoxamine inhibits AGE/ALE formation and development of chronic complications in diabetic and obese rats: mechanisms of action of pyridoxamine
John Baynes (South Carolina, SC, USA)
Application of LC-MS/MS for the quantitation and peptide mapping of glycation, oxidation and nitrosation adducts
12:50 - 14:15 Lunch and Poster Session
Application of monoclonal antibody libraries for the measurement of glycation adducts
Seikoh Horiuchi (Kumamoto, Japan)
Accumulation of fructosyl-lysine and advanced glycation endproducts in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats
Selected Poster Presentation - Nikolaos Karachalias (Essex, UK)
Proteomic analysis of N-omega-(carboxymethyl)arginine formation in ribonuclease-glyoxal model systems
Selected Poster Presentation - Jennifer Ames (Reading, UK)
Enzymatic deglycation - a new paradigm or an epiphenomenon?
Ben Szwergold (Dartmouth Medical School, Hanover, NH, USA)
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Molecular Mechanisms of Signalling
Pfizer Research Colloquium
Nitric oxide and cell respiration: physiology and pathophysiology
Salvador Moncada (Wolfson Institute for Biomedical Research, UK)
MnSOD overexpression-induced senescence is independent of Nox1 activity
Selected Poster Presentation - Lars Behrend (Ulm, Germany)
A functional polymorphic variant of DDAH2 in a basal promoter element
Selected Poster Presentation - Cam Thanh Tran (University College London, UK)
Sprouty-attenuator in RTK signalling pathway
Selected Poster Presentation - Xuan Li (Birmingham, UK)
Age-related vasomotor dysfunction may be due to altered Akt status in the endothelium
Selected Poster Presentation - Anthony Smith (Linus Pauling Institute, Oregon, USA)
11:00 - 11:30 Coffee/Tea Break
Rapid S-nitrosothiol metabolism by platelets and megakaryocytes
Selected Poster Presentation - Chirag Shah (Westminster, UK)
Colocalisation of cell surface receptors at high spatial solution by single particle fluorescence imaging
Selected Poster Presentation - Ioannis Karakikes (Essex, UK)
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