Organizers:
Jeremy Turnbull (University of Liverpool, UK)
Cathy Merry (University of Manchester, UK)
John Couchman (University of Copenhagen, Denmark)
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Development and model systems
Chairs:
Catherine Merry (University of Manchester, UK)
Tarja Kinnunen (University of Liverpool, UK)
12:00 - 14:00 Registration and lunch
Heparan sulfate proteoglycans in gradients and niche
Hiroshi Nakato (University of Minnesota, USA)
Specific heparan sulphotransferases regulate axon guidance in the mouse visual system
John Mason (Edinburgh University, UK)
Sulf1 and Sulf2 differentially modulate FGF2, GDNF and NGF growth factor signaling pathways during the postnatal development of the cerebellum
Selected oral communication - Ina Kalus (Bielefeld University, Germany)
Extracellular degradation of the RB4CD12 anti-heparan sulfate epitope in CHO cells and in the mouse brain by HSulf-1 and HSulf-2
Selected oral communication - Kenji Uchimura (National Institute for Longevity Sciences, Japan)
Tarja Kinnunen (University of Liverpool, UK)
16:00 - 16:30 Coffee/tea break
Heparan sulphate in vascular patterning
Holger Gerhardt (Cancer Research UK)
Chondroitin sulphate proteoglycans and developmental angiogenesis
Selected oral communication - Sébastien Le jan (Uppsala University, Sweden)
Control of zebrafish vascular development by fine editing of heparan sulphate
Sally Stringer (University of Manchester, UK)
Regulation of skeletal morphogenesis by sulphated proteoglycans in Zebrafish
Henry Roehl (University of Sheffield, UK)
HSPG-deficient zebrafish uncovers new aspects of multiple osteochondromas
Selected oral communication - Wiweger Malgorzata (Leiden University Medical Center, The Netherlands)
The essential role of heparan sulphate during the commitment of embryonic stem cells to mesodermal lineages
Selected oral communication - Rebecca Baldwin (University of Manchester, UK)
Fundamental differences in heparan sulfate on mouse and human embryonic stem cells
Selected oral communication - Claire Johnson (The University of Manchester, UK)
20:55 - 22:00 Poster viewing and drinks reception
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Structure-function and biosynthesis
Chairs:
David Fernig (University of Liverpool, UK)
Malcolm Lyon (University of Manchester, UK)
Heparan sulfate biosynthesis - is there a code?
Ulf Lindahl (Uppsala University, Sweden)
The heparin/heparan sulphate binding interactions of bone morphogenetic protein-7 (BMP-7)
Selected oral communication - Christopher Rider (Royal Holloway University of London, UK)
A structural characterisation of heparan sulphate binding to RPTPs
Selected oral communication - Charlotte Coles (University of Oxford, UK)
The heparin-binding domain of heparin-binding epidermal growth factor-like growth factor (HB-EGF) mediates localization to cell-cell contact sites
Selected oral communication - Robin Prince (Massachusetts Institute of Technology, USA)
Receptor activities of heparan sulfate proteoglycans
Jeff Esko (Glycobiology Research and Training Center, University of California, San Diego, USA)
10:45 - 11:15 Coffee/tea break
Heparanase: one molecule with multiple functions in cancer progression
Israel Vlodavsky (Hadassa University Hospital, Israel)
Occurrence of heparin serglycin proteoglycan in a primitive basophil from the invertebrate chordate Styela plicata (Tunicata)
Selected oral communication - Mauro Pavao (Federal University of Rio de Janeiro, Brazil)
Involvement of heparan sulfate in slit-robo interactions: evidence that specific sulfate groups are essential
Selected oral communication - Yassir Ahmed (University of Liverpool, UK)
The HIV-1 envelope glycoprotein features four HS binding domains, including the coreceptor binding site
Selected oral communication - Hugues Lortat-Jacob (Institut de Biologie Structurale, Grenoble, France)
Dynamic fluctuations of FGF-2 ligand on the cell surface
Selected oral communication - Laurence Duchesne
16:00 - 18:00 Poster session one (odd numbers) with coffee/tea
Cellular design of heparan sulfate domain structure
Lena Kjellen (Uppsala University, Sweden)
Liver heparan sulphate: expression changes of modifying enzymes and structural alterations in chronic fibrogenic diseases and hepatocellular carcinoma
Selected oral communication - Peter Tatrai (Semmelweis University, Hungary)
Redirecting the substrate specificity of heparan sulfate 2-O-sulfotransferase by structurally guided mutagenesis
Selected oral communication - Heather Bethea (University of North Carolina, Chapel Hill, USA)
Proteoglycan-specific glycosaminoglycan expression
Selected oral communication - Gerdy ten Dam (Radboud University Nijmegen Medical Center, The Netherlands)
20:55 - 22:00 Poster viewing with refreshments
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Chemical/structural biology and new tools
Chairs:
Jeremy Turnbull (University of Liverpool, UK)
Ed Yates (University of Liverpool, UK)
Phage display antibodies to glycosaminoglycans: looking at saccharide domains under the microscope
Toin van Kuppevelt (Radboud University, The Netherlands)
Visualization of functional GAG-domains in renal tissues
Selected oral communication - Jacob van den Born (University Medical Medical Centre Groningen, The Netherlands)
Development and evaluation of heparan sulfate glycoarrays for protein interaction screening
Selected oral communication - Andrew Powell (Liverpool John Moores University, UK)
Feasability of "immunosequencing" of heparan sulphates using phage display-derived antibodies
Selected oral communication - Xander van Wijk (Radboud University, The Netherlands)
Heparin binding sites on proteins of the TGF-¿Ò-like cystine-knot family
Barbara Mulloy (National Institute for Biological Standards, UK)
10:35 - 11:00 Coffee/tea break
Tackling the practical challenges of HS research
Ed Yates (University of Liverpool, UK)
An enzymatic approach for developing heparan sulphate-based therapeutics
Jian Liu (University of North Carolina, Chapel Hill, USA)
Enzymatically designed synthetic heparin substrates to probe the specificity of heparanase
Selected oral communication - Sherket Peterson (University of North Carolina, Chapel Hill, USA)
Rapid purification and high sensitivity analysis of heparan sulfate from tissues
Selected oral communication - Scott Guimond (The University of Liverpool, UK)
Artificial Golgi: redesigning the biological activities of heparan sulfate
Robert Linhardt (Rensselear Polytech Institute, USA)
14:00 - 18:00 Free time/afternoon excursion
Probing biological functions of heparan sulfate using synthetic compounds.
Geert-Jan Boons (The University of Georgia, USA)
Inhibition of vaccinia virus infection using synthesized heparin oligosaccharides
Selected oral communication - Shang-Cheng Hung (Genomics Research Center, Taiwan)
Ion mobility MS for the elucidation of GAG structure: specificity for protein binding
Julie Leary (University of California, Davis, USA)
Ion mobility mass spectrometry; a new tool for structural biology
Sponsor presentation - Andrew Rogers (Waters Ltd UK)
Analysing the heparin interactome: a new method for the localisation of heparin-binding sites
Selected oral communication - Alessandro Ori (University of Liverpool, UK)
20:50 - 22:00 Poster viewing with refreshments
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Signalling and cell biology
Chairs:
John Couchman (University of Copenhagen, Denmark)
Sally Stringer (University of Manchester, UK)
Regulation of cell signaling by glypicans
Jorge Filmus (University of Toronto, Canada)
Regulation of alphaVbeta3 integrin by Syndecan-1 in tumorigenesis and angiogenesis
Alan Rapraeger (University of Madison, USA)
Perlecan heparan sulfate and heparanase control the terminal differentiation of chondrocytes by modulating the signaling of FGF18
Selected oral communication - John Michael Whitelock (University of New South Wales, Australia)
Role of heparan sulfate in fibroblast growth factor signalling
Dorothe Spillmann (Uppsala University, Sweden)
Heparan sulphate dependent formation of ¿undisruptable¿ hedgehog multimers
Selected oral communication - Kay Grobe (University of Münster, Germany)
10:40 - 11:00 Coffee/tea break
A dual role of Syndecan-4 in neural development: differentiation and migration
Roberto Mayor (University College London, UK)
A cell adhesion pathway for syndecan-4 to signal in trans to integrin beta1
Selected oral communication - James Whiteford
Src-mediated syndecan-4 phosphorylation regulates focal adhesion stability, integrin trafficking and cell migration
Selected oral communication - Mark Morgan (University of Manchester, UK)
Guido David (Leuven University, Belgium)
3-O-sulfation increases FGFR2b function during submandibular gland epithelial branching morphogenesis
Matthew Hoffman (NIH Maryland, USA)
16:00 - 18:00 Poster session two (even numbers) with coffee/tea
Reflections on HS: defining a molecular code
John Gallagher (University of Manchester, UK)
20:00 - 21:30 Conference Dinner
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Disease and therapies
Chairs:
Anthony Day (University of Manchester, UK)
Jeremy Turnbull (University of Liverpool, UK)
The Sulfs as modulators of heparan sulfate dependent signalling
Steve Rosen (University of California, San Francisco, USA)
Y402H variants of complement factor H have different GAG-binding sites within human macula
Selected oral communication - Anthony Day (University of Manchester, UK)
Roles of heparan sulfate in amyloidosis
Jin-Ping Li (Uppsala University, Sweden)
The roles of heparan sulfate and heparanase in the pathophysiology of diabetes type 1
Craig Freeman (Australian National University, Australia)
10:30 - 11:00 Coffee/tea break
Heparanase: a multifunctional regulator of the tumor microenvironment and target for cancer therapy
Ralph Sanderson (University of Alabama, USA)
Defining the cell surface proteoglycan signature of a malignant tumour cell. I. differential roles of glypicans 5 and 6
Selected oral communication - Katia Lacrima (University of Parma, Italy)
Are glycosaminoglycans amenable drug targets?
Selected oral communication - Andreas Kungl (ProtAffin Biotechnologie, Austria)
Small molecule inhibitors of glycosaminoglycan biosynthesis as a substrate reduction therapy for mucopolysaccharidosis
Selected oral communication - Brett Crawford (Zacharon Pharmaceuticals, USA)
Heparan sulphate mimetics as anticancer ¿small-glyco drugs
Selected oral communication -Eric Cabannes (Endotis Pharma, France)
Heparan sulphate and the mucopolysaccharidoses
John Hopwood (Adelaide Childrens Hospital, Australia)
Discussion and meeting close
13:00 Lunch and depart (packed lunch)
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