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Proteinase Structure and Function
Organizers:
Robin Leatherbarrow (Imperial College London, UK)
Brian Austen (St. Georges Hospital Medical School, London, UK)
Chris Southan (Oxford Glycosciences, UK)
John Deadman (Thrombosis Research Institute, London, UK)
18:00 - 20:00 Registration
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Wednesday morning
Chair:
Brian Austen (St. Georges Hospital Medical School, London, UK)
Wednesday 10 September 2003
Brian Austen (St. Georges Hospital Medical School, London, UK)
Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine
Tim Clausen (Institute for Molecular Pathology, Vienna, Austria)
Proteasome function in antigen presentation
Jennifer Rivett (Bristol, UK)
10:30 - 11:00 Coffee/tea break
Protease ligand conformation and inhibitor design
David Fairlie (Queensland, Australia)
Comparative modelling of angiotensin-converting enzyme-2 (ACE2)
Selected Poster Presentation - Jodie Guy (Leeds, UK)
An integrated platform for high throughput expression of human proteases
Selected Poster Presentation - Daniele Carettoni (Axxam, Italy)
FAK serves as a calpain protease-targeting adaptor molecule
Selected Poster Presentation - Neil Carragher (The Beatson Institute for Cancer Research, Glasgow, UK)
The crystal structure of the proprotein processing proteinase Furin
Selected Poster Presentation - Manuel Than (Max-Planck-Institut für Biochemie, Martinsried, Germany)
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Wednesday afternoon
Chair:
Christian Sommerhoff (Munich, Germany)
Wednesday 10 September 2003
Bioinformatic analysis of the beta secretases, BACE1 and BACE2: integrating genome and transcript data from humans, rodents and fish
Chris Southan (Oxford Glycosciences, UK)
A presenilin dimer at the core of the g-secretase enzyme? Insights from parallel analysis of Notch 1 and APP proteolysis
Raphael Kopan (St Louis, MO, USA)
15:30 - 16:00 Coffee/tea break
Proteasome inhibitors induce apoptosis in human hepatoma cells by a c-Jun/JNK pathway
Sonia Emanuele (Palermo, Italy)
Chemical genetic and chemical biological applications of protease affinity labels
Brian Walker (Belfast, UK)
17:30 - 19:00 Drinks reception and poster viewing
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Thursday morning
Chair:
Chris Southan (Oxford Glycosciences, UK)
Thursday 11 September 2003
Structural studies on acyl enzyme complexes of serine proteases
Chris Schofield (Oxford, UK)
Zinc metalloproteinases as therapeutic targets in human disease
Anthony Turner (Leeds, UK)
10:30 - 11:00 Coffee/tea break
Intramembrane proteolysis by signal peptide peptidase
Bruno Martoglio (Swiss Federal Institute of Technology, Zurich, Switzerland)
The role of the apoptosome in caspase activation and cell death
Kelvin Cain (Leicester, UK)
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Thursday afternoon
Chair:
Anthony Turner (Leeds, UK)
Thursday 11 September 2003
Subcellular trafficking and phosphorylation of endothelin-converting enzyme-1
Ian Smith (Cryptome Research, Baker Medical Institute, Melbourne, Australia)
Functional profiling of proteases: PNA-encoded small molecule probes
Jennifer Harris (Genomics Institute of the Novartis Research Foundation, San Diego, CA, USA)
15:30 - 17:30 Coffee/tea and poster session
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Friday morning
Chair:
Jennifer Rivett (Bristol, UK)
A mutagenesis approach to the understanding of TIMP specificity
Gillian Murphy (Cambridge, UK)
Mechanisms regulating protease function at the cell surface: the versatility of the plasminogen activation system
Vince Ellis (East Anglia, UK)
10:30 - 11:00 Coffee/tea break
Mast cell tryptases: unequal siblings
Christian Sommerhoff (Munich, Germany)
Substrate specificity of serine proteases
Edwin Madison (Corvas International Inc., San Diego, CA, USA)
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Friday afternoon
Chair:
Robin Leatherbarrow (Imperial College London, UK)
Human kallikreins: gene locus characterization and clinical applications
Eleftherios Diamandis (Toronto, Canada)
Signal peptidase: an atypical serine protease
Mark Lively (Winston-Salem, NC, USA)
15:30 - 16:00 Coffee/tea break
Protease-inhibitor docking and database searching for the inhibitor canonical loop conformation
Richard Jackson (Leeds, UK)
Molecular structure of human angiotensin converting enzyme (ACE)
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