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60th Harden Conference - Inositol Phosphates and Lipids - Regulation and Functions

13—18 August 2005

St Martin's College, Ambleside, Lake District, UK



Organizers:
Robin Irvine (University of Cambridge, UK)
Pete Cullen (University of Bristol, UK)
CellSignals, Inc.
Phil Godfrey Memorial Fund
Trends in Cell Biology

Special Events

Wednesday 17 August 2005
Chair:
Len Stephens
20:00 - 21:00
Plenary Speaker
Phosphoinositide kinases and human disease
Lew Cantley (Harvard University, USA) (Harvard University, USA)

Timetable

Saturday 13 August 2005Sunday 14 August 2005Monday 15 August 2005Tuesday 16 August 2005Wednesday 17 August 2005
21:30 - 21:45
PtdIns(3,4,5)P3 signalling

09:00 - 22:00
PtdIns(3,4,5)P3 signalling

12:00 - 12:30
Other 3-phosphorylated lipids

21:15 - 21:30
PIP kinases

11:45 - 21:45
PtdIns(4,5)P2 functions and tools

12:00 - 12:30
Inositol phosphates

21:15 - 21:30
Enzymes

09:45 - 12:30
Enzymes


PtdIns(3,4,5)P3 signalling

Chair:
Peter Downes (University of Dundee, UK)
Saturday 13 August 2005
21:30 - 21:45
Redox regulation of inositol lipid signalling
Selected oral communication - Peter Downes (University of Dundee, UK)
Sunday 14 August 2005
09:00 - 09:45
Spatially encoded PKC signals
Peter Parker (Cancer Research UK)
09:45 - 10:30
Regulation of endocytic receptor down-regulation by phosphoinositides
Harald Stenmark (Norwegian Radium Hospital, Norway)
11:00 - 11:45
Phosphatidylinositol 3,5-bisphosphate, the ¿newest¿ PtdInsP2 isomer: metabolism and multiple functions
Bob Michell (University of Birmingham, UK)
11:45 - 12:00
ArPIKfyve-PIKfyve-PtdIns 3,5-P2 axis in hyperosmotic- and insulin-regulated glucose transport in 3T3-L1 adipocytes
Selected oral communication - Assia Shisheva (Wayne State University School of Medicine, USA)
12:30 - 13:00
General discussion
19:30 - 20:15
Phosphoinositide signalling at the neuronal synapse
Pietro De Camilli (Yale University, USA)
20:15 - 21:00
Molecular mechanisms for spatial PIP2 generation
Richard Anderson (University of Wisconsin-Madison, USA)
21:00 - 21:15
Investigating the roles of class II phosphoinositide 3-kinases
Selected oral communication - Michael Fry (University of Reading, UK)
21:30 - 22:00
General discussion

Other 3-phosphorylated lipids

Sunday 14 August 2005
10:30 - 11:00 Coffee/tea break

12:00 - 12:15
S. cerevisiae AP-1 complex is required for Fab1p-dependent protein sorting to the vacuole lumen
Selected oral communication - John Phelan (University College London, UK)
12:15 - 12:30
Regulatory interactions between myotubularin PI 3-phosphatases and inactive pseudophosphatases.
Selected oral communication - Fred Robinson (University of California San Diego, USA)
13:00 - 14:00 Lunch

PIP kinases

Sunday 14 August 2005
16:00 - 18:00 Poster session

18:30 - 19:30 Dinner

21:15 - 21:30
Role of class II phosphoinositide 3-kinases in cell signalling
Selected oral communication - Tania Maffucci (University College London, UK)

PtdIns(4,5)P2 functions and tools

Monday 15 August 2005
10:30 - 11:00 Coffee/tea break

11:45 - 12:00
Role of PIP kinases in Drosophila phosphoinositide signalling
Selected oral communication - Deepti Trivedi (The Babraham Institute, UK)
12:15 - 12:30
Nuclear inositide signalling: role of PLC beta1 in erythroleukemia cells
Selected oral communication - Lucio Cocco (University of Bologna, Italy)
13:00 - 14:00 Lunch

19:30 - 20:15
Co-incidence detection in phosphoinositide signalling
Harvey McMahon (MRC-LMB, UK)
20:15 - 21:00
Molecular mechanisms of phosphoinositide 3-kinase alpha regulation and oncogenesis
Roger Williams (MRC-LMB, Cambridge, UK)
21:00 - 21:15
Gb residues relevant for interaction and stimulation of phosphoinositide 3-kinase g (PI3Kg) enzymatic activities
Selected oral communication - Aliaksei Shymanets (University of Duesseldorf, Germany)
21:15 - 21:45
General discussion

Structural Aspects

Monday 15 August 2005
16:00 - 18:00 Poster session

18:30 - 19:30 Dinner

Inositol phosphates

Tuesday 16 August 2005
10:30 - 11:00 Coffee/tea break

12:00 - 12:15
Inositol phosphate metabolism and its role in cell motility and lithium sensitivity in Dictyostelium discoideum
Selected oral communication - Jason King (Cardiff University, UK)
12:15 - 12:30
The complexation and precipitation behaviour of myo-inositol hexakisphosphate in the presence of multivalent cations
Selected oral communication - Alvaro Diaz (UDELAR, Uruguay)
13:00 - 14:00 Lunch

16:00 - 18:00 Poster session

18:30 - 19:30 Dinner

Pyro-phosphorylated inositol phosphates


Enzymes

Tuesday 16 August 2005
21:15 - 21:30
Phosphorylation of proteins by inositol pyrophosphates
Selected oral communication - Rashna Bhandari (Johns Hopkins University, USA)
Wednesday 17 August 2005
09:45 - 10:30
Detection of a trace amount of phosphoinositides by phosphoinositide-binding domains
Tadeomi Takenawa (University of Tokyo, Japan)
10:30 - 11:00 Coffee/tea break

11:45 - 12:00
Breakdown of plasma membrane PtdIns(4,5)P2 is required for mast cell exocytosis
Selected oral communication - Gerry Hammond (Cancer Research UK London Research Institute)
12:00 - 12:15
The role of FAPP, CERT and OSBP1 PI4P-binding proteins at the Golgi
Selected oral communication - Maria Antonella De Matteis (Consorzio Mario Negri Sud, Santa Italy)
12:15 - 12:30
Type I alpha inositol polyphosphate 4-phosphatase generates and terminates PI3-kinase signals on endosomes and the plasma membrane
Selected oral communication - Ivan Ivetac (Monash University, Australia)
13:00 - 14:00 Lunch

18:30 - 20:00 Conference dinner

Chair:
Len Stephens
20:00 - 21:00
Plenary Speaker
Phosphoinositide kinases and human disease
Lew Cantley (Harvard University, USA) (Harvard University, USA)