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8th International Symposium on P450 biodiversity and biotechnology

23—27 July 2006

Swansea Medical School, Wales, UK



Organizers:
Professor Steven L. Kelly
Dr Diane E. Kelly
Professor David C. Lamb
Sponsors:
Insect P450
Speakers:
To be confirmed
Caroline McCart (University of Bath, UK)
Transcriptional regulation of insect cyt.P450 genes by plant allelochemicals and insecticides
Cynthia McDonnell (University of Illinois, USA)
Expression of Halloween P450 genes mediating ecdysteroid biosynthesis in the tobacco hornworm Manduca sexta
Kim Furbo Rewitz (Rosklide University, Denmark)
The potential for cytochrome P450s to confer Insecticide Resistance in Drosophila melanogaster
Phillip Daborn (University of Melbourne, Australia)
Evolution of insect P450s
Rene Feyereisen (INRA Antibes, France)
Ecotoxicology/Biotechnology and P450
Speakers:
Oxidative metabolic profiling of xenobiotics by human p450's expressed in tobacco cell suspension cultures
Burkhard Schmidt (RWTH Aachen University, Germany)
The involvement of cyt.P450 system in the fate of 2,4,6-trinitrotoluene in european eel
Camilla Della Torre (University of Sienna, Italy)
Bioassays for Persistant Organic Pollutants in Transgenic Plants carrying AhR and GUS Reporter Genes
Hideo Ohkawa (Fukuyama University, Japan)
Ema p450's
Istan Molnar (University of Arizona, USA)
Monooxygenation of methoxychlor in the channel catfish, Ictalurus punctatus
Margaret James (University of Florida, USA)
Biodegradation of explosives by the cytochrome P450 XpIA from Rhodococcus and its targeted application for phytoremediation of RDX
Neil Bruce (University of York, UK)
Proteomic analysis of cyt. P450 enzymes
William Griffiths (University of London, UK)
P450 Biodiversity/Evolution and Function
Speakers:
Walking the Line of Cytochrome P450 evolution
David Nelson (University of Tennessee, USA)
Biodiversity of CYP51 in Trypanosomes. A single amino-acid substitution alters substrate preferences of sterol 14á-demethylases
Galina Lepesheva (Vanderbilt University, USA)
P450ome of the white rot fungus Phanerochaete chrysosporium; structure, evolution and regulation of expression of genomic P450 clusters
Jagjit Yadav (University of Cincinnati College of Medicine, USA)
Diversity of cytochromes P450 and pathway evolution in early Deuterostomes
Jed Goldstone (Woods Hole Oceanographic Inst. USA)
Antiquity of chordate CYP Gene families: structural a Funtional Evolution of CYP1 and CYP3 lines
John Stegman (Woods Hole Oceanographic Institute, USA)
P450 Activity and Redox Partners
Speakers:
P450 oxidoreductase deficiency; a new disorder of steroidogenesis affecting all microsomal P450 enzymes
Amit Pandey (Bern University, Switzerland)
Flavoprotein P450 BM3: Biotechnological exploitation and novel mechanistic insights
Andrew Munro (University of Manchester, UK)
Cytochrome P450 systems in the pathogen Mycobacterium tuberculosis
Kirsty McLean (University of Manchester, UK)
Protein-mediated control of P450 Catalysis
Paul Ortiz de Montellano (University of Caifornia, USA)
Streptomyces P450 electron donors
Young-Jin Chun (Verderbilt University, USA)
P450 Protein Structure/Proteomics
Speakers:
Structural Diversity of Human Drug Metabolizing P450's
Eric Johnson (The Scripps Institue, USA)
Structural determinants of diverse hydroxylation patterns of polyketides by the P450 monooygenase PikC (CYP107L1)
Larissa Podust (Vanderbilt University, USA)
CYP74C3 and CYP74A2: plant cyt. P450 enzymes whose activity is regulated by detergent micelle-association
Richard Hughes (John Innes, UK)
Title to be confirmed
Tom Poulos (University College Irvine, USA)
Plant P450
Speakers:
RNAi-mediated suppression of CYP82E4 allows transgenic reduction of nornicotine content in Nicotiana tabacum
Balazs Siminszky (North Carolina State University, USA)
Abietadienol/ abietadienol oxidase PtAO (CYP720B1)
Bjoern Hamberger (University of British Columbia, Canada)
Functions and evolution of the CYP98 family in higher plants
Daniele Werck-Reichart (IBMP-CNRS, France)
Cytochrome P450 CYP710AEncodes the Sterol C-22 Desaturase in Plants
Diasaku Ohta (Kyoto University, Japan)
The Role of Cytochrome P450 Enzymes in the Biosynthesis of Camalexin
Erich Glawischnig (Munich Technical University, Germany)
Dwarfism and P450 mediated C-6 oxidation of plant steroid hormones
Gerrad Bishop (Imperial College, UK)
A Bioinformatics/Meta approach to map the P450 superfamily onto metabolic pathways based on public expression data
Juergen Ehlting (IBMP-CNRS, France)
CYP703A, an ancient P450 involved in microspore development of terrestial plants
Marc Morant (Royal Vet. And Agri. University, Denmark)
Functional genomic analysis of tropane alkaloid biosynthesis, Hyoscyamus niger, reveals a cytochrome P450 involved in rearrangement of littorine
Patrick Covello (NRC Plant Biotechnology Inst. Canada)
The impact of Cytochromes P450 in evolution of Cyanogenic glucosides in terrestrial plants
Søren Bak (Royal Vet. and Agri. University, Denmark)
Microbial P450
Speakers:
Title to be confirmed
Hans Cools (Rothamsted Research, UK)
Improvement of enzyme functions of a cytochrome P450 from Nonomuraea recticatena by directed evolution
Hiroki Kabumoto (Mercian Corporation, Japan)
Engineered topogenesis of recombinant drug metabolising enzymes (CYP and P450 reductases) to the cell peripheral zones for efficient biotransformations
Mustak Kaderbhai (UWA, UK)
15beta-hydroxylase from B.megaterium
Rita Bernhardt (University of Saarland, Germany)
The CYP102A Subfamily: Similar, but Different
Sabine Eiben (University of Stuttgart, Germany)
Structure and function of cytochromes P450 CYP120A1 from Synechocystics spp. 6803
Stephen Sligar (University of Illinois, USA)