Sponsors:
GlaxoSmithKline
The British Heart Foundation
International Lecithin and Phospholipid Society
The Vascular Biology Group of the Royal Free Hospital
Timetable
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The Transport and Distribution of Triacylglycerols
Organizers:
Keith Suckling (GlaxoSmithKline, Stevenage, UK)
Richard Bruckdorfer (UCL, UK)
Geoffrey Gibbons (Radcliffe Infirmary, Oxford, UK)
David Saggerson (London, UK)
Klaus Wahle (Rowett Research Institute, Aberdeen, Scotland, Uk)
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Session I
Chair:
Keith Frayn (Oxford, UK)
14:00 - 15:30 Arrival and Regisration
15:30 - 15:45 Welcome to Delegates
Dietary fatty acids and chylomicron synthesis and secretion
Christine Williams (Reading, UK)
Synthesis and function of hepatic VLDL
Geoffrey Gibbons (Radcliffe Infirmary, Oxford, UK)
17:15 - 18:00 Coffee/tea break
Membrane cholesterol and the regulation of signal transduction
Christopher J Fielding (The Laurens Van Deenen Lecture) (UCSF, CA, USA)
19:30 Reception and buffet
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Session I (continued)
Chair:
Keith Frayn (Oxford, UK)
Genetics and protein structures regulating triglyceride-rich lipoprotein production
Carol Shoulders (MRC Clinical Sciences Centre, Imperial College, London, UK)
Enterocyte fatty acid (FA) uptake and intestinal fatty acid binding protein
Patrick Tso (Cincinnatti, OH, USA)
10:30 - 11:00 Coffee/tea break
Trevor Redgrave (Western Australia)
12:30 - 14:00 Lunch and poster session 1
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Hot topic presentations
Insulin-induced FAT/CD36 translocation increases cardiac long-chain fatty acid uptake and utilization in obese Zucker rats
Jan Glatz (Maastricht, The Netherlands)
Abnormal triglyceride fatty acyl composition in skin of Elovl3-ablated mice
Anders Jacobsson (Stockholm, Sweden )
Conversion of hexadecanoic acid to hexadecenoic acid by rat Delta 6 desaturase
Philippe Legrand (Rennes, France)
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Lipids and Transcription Factors
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Session II
Chair:
Geoff Gibbons (Oxford, UK)
FXR and LXR: Lipid sensors that control lipid homeostasis
Peter Edwards (UCLA, CA, USA)
Regulation of lipoprotein trafficking in the kidney: role of inflammatory mediators and transcription factors
LXR and HNF-4: Key regulators in reverse cholesterol transport
Maurizio Crestani (Milan, Italy)
The adipose-restricted decrease in PPARgamma induces lipodystrophy with limited metabolic consequences
Chris Knouff (INSERM, Illkirch, France)
17:00 - 18:00 Coffee/tea and poster session 1
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Session II (continued)
Chair:
Peter Edwards (UCLA, CA, USA)
Critical roles of the nuclear receptor PPAR-beta in skin wound healing
Walter Wahli (Lausanne, Switzerland)
Adipocyte cholesterol balance in obesity
Isabelle Dugail (INSERM, Paris, France)
10:45 - 11:15 Coffee/tea break
14:00 - 16:00 Boat trip on the Thames (Isis)
17:00 - 18:00 Coffee/tea and croquet on the lawn
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Hot topic presentations
10:45 - 11:15 Coffee/tea break
Transcriptional regulation of SREBP-1c: a key regulator of lipogenesis
Elizabeth Tarling (Nottingham, UK)
Molecular composition of phospholipids and gene expression in rat brain are affected by dietary fatty acids
Gwendolyn Barcelo-Coblijn (Biological Research Center, Hungary)
Chylomicron remnant-like particles modify endothelial cell production of vasoactive mediators
Michelle Evans (Royal Veterinary College, London, UK)
Saturated fatty acids with 12-16 carbons activate HNF-4a though depressing lipogenic gene expression in the liver of hyperinsulinemic rats
Luciano Binaglia (Perugia, Italy)
B-lymphocyte antigen receptor (BCR) directs the activation of transcription factors NFAT and NF-kB via distinct molecular mechanisms
Wasif Khan (Nashville, TN, USA)
17:00 - 18:00 Coffee/tea and croquet on the lawn
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New Aspects in Cholesterol Research
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Session III
Chair:
Keith Suckling (GlaxoSmithKline, Stevenage, UK)
Wednesday 10 September 2003
SR-BI in HDL metabolism, atherosclerosis and heart disease: Lessons from knockout mice
Bernardo Trigatti (McMaster, Canada) and Monty Krieger (MIT, MA, USA)
Caveolins and membrane cholesterol
Elina Ikonen (National Institute for Public Health, Helsinki, Finland)
10:45 - 11:15 Coffee/tea break
ABC-A1 transporters - regulation of cholesterol efflux
Brian Knight (Hammersmith Hospital, London, UK)
12:45 - 14:00 Lunch and poster session 2
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Hot topic presentations
Wednesday 10 September 2003
10:45 - 11:15 Coffee/tea break
The effect of cellular lipid imbalance on insulin receptor activation
Saara Vainio (Helsinki, Finland)
Circulating levels of chemokines JE and KC in female C3H apoE-/- and C57BL apoE-/- mice as potential markers of atherosclerosis
Suzanne Parkin (Royal Free and University College Medical School, London, UK)
Fecal sterol output is increased by arachidyl amido cholanoic acid (aramchol) in rats
Alicia Leiken-Frenkel (Tel Aviv, Israel)
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Lipid Oxidation: a Key Process in Pathology or an Epiphenomenon?
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Session IV
Chair:
Richard Bruckdorfer (UCL, UK), Victor Darley-Usmar (Birmingham, AL, USA)
Wednesday 10 September 2003
Lipid oxidation and its role in atherosclerosis: an overview
Wendy Jessup (New south Wales, Australia)
Measurement of lipid peroxidation in vivo
Kevin Moore (Royal Free Hospital, London, UK)
16:45 - 18:00 Coffee/tea and poster session 2
Triglyceride transport and metabolism. Where is the regulation?
Thomas Olivecrona (The 50th Anniversary Lecture)
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Hot topic presentations
Wednesday 10 September 2003
Lipid oxidation products as markers of oxidative stress: validation studies in animal models
Maria Kadiiska (Research Triangle Park, North Carolina, USA)
Specific markers of lipid peroxidation issued from n-3 and n-6 fatty acids
Michel Guichardant (Villeurbanne, France)
A novel antioxidant action of ethanolamine plasmalogens in lowering the oxidizability of membranes
Ryouta Maeba (Teikyo University School of Medicine, Tokyo, Japan)
Connection of lipid peroxide oxidation with sphingomyelin cycle pathway in the development of alzheimer disease
Alice Alessenko (Institute of Biochemical Physics, Moscow, Russia)
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Session IV (continued)
Chair:
Wendy Jessup (New South Wales, Australia), Klaus Wahle (Rowett Research Institute, Aberdeen, UK)
Thursday 11 September 2003
Phosphatidylethanolamines and lipid oxidation
Bernd Englemann (Ludwig-Maximilians, Munich, Germany)
Mechanisms of signal transduction mediated by oxidized lipids
Victor Darley-Usmar (Birmingham, AL, USA)
10:30 - 11:00 Coffee/tea break
Antioxidant and atherosclerosis
Etsuo Niki (National Institute of Advanced Industrial Science and Technology, Osaka, Japan)
What does this lipoprotein oxidation phenomenon mean?
Gorden Ferns (Open Discussion) (Surrey, UK)
12:30 - 13:00 Closing Ceremony (Followed by Lunch and Departure)
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