Enzyme Mechanism - A Structural Perspective
Organizers:
John Ingledew (St. Andrews, UK)
Jim Naismith (St. Andrews, UK)
Steve Chapman (Edinburgh, UK)
Oxygen activation in a copper-containing amine oxidase
Carrie Wilmot (Minnesota, MN, USA)
Diflavin reductases and oxygen activation
Nigel Scrutton (Leicester, UK)
NO synthase: a substrate-controlled conformational see-saw
Simon Daff (Edinburgh, UK)
Molecular recognition engineering in P450cam catalysis
12:00 - 14:00 Lunch and posters
Cofactor processing and catalysis in galactose oxidase
Mike McPherson (Leeds, UK)
Structural studies on the respiratory complexes
So Iwata (Imperial College, London, UK)
Mechanism of dioxygen sensing in the hypoxic response
Chris Schofield (Oxford, UK)
Haem-oxygen reactive intermediates: catalysis by the two-step
Steve Sligar (Chicago, IL, USA)
17:30 - 18:30 Reception in poster area
The reaction coordinate of glycosyltransfer: structural analysis of glycosidases and glycosyltransferases
The molecular mechanism for inhibition of HMG-CoA reductase by rosuvastatin
Geoff Holdgate (AstraZeneca, Cheshire, UK)
Unusual carbohydrate chemistry
Jim Naismith (St Andrews, UK)
Structure and reactivity in the non-mevalonate pathway of isoprenoid biosynthesis
12:00 - 13:20 Lunch and posters
Twists and turns: a tale of two shikimate pathway enzymes
Katy Brown (Imperial College, London, UK)
Experiences with the shikimate pathway enzyme as targets for rational drug design
John Coggins (Glasgow, UK)
A two-faced molecule offers NO explanation: the proximal binding of nitric oxide to haem
David Lawson (John Innes Centre, UK)
Structural biology of microbial biosynthesis: pantothenate and other systems
Tom Blundell (Cambridge, UK)