Organizers:
Alan Clark (Organon, UK)
Brian Henry (Organon, UK)
Jeremy Presland (Organon, UK)
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GPCR Allosterism and Accessory Proteins: New Insights into Drug Discovery
09:00 - 10:00 Registration and coffee/tea
GPCR allosterism: the promise and the problem(s)
Arthur Christopoulos (Melbourne, Australia)
GPCR allosterism: challenges for drug discovery
Stephen Rees (GlaxoSmithKline, UK)
11:20 - 11:40 Coffee/tea break
Allosteric modulators of metabotropic glutamate receptors: Lessons learned from mGlu1, mGlu2 and mGlu5 potentiators and antagonists
Michael Johnson (Lilly Research Laboratory, USA)
13:00 - 14:30 Lunch and poster session
GPCR accessory proteins: targets for future GPCR drug discovery?
Jeremy Presland (Organon, UK)
Interactions between G protein-coupled receptors and periplakin: a selective means to regulate G protein activation
Graeme Milligan (Glasgow, UK)
15:50 - 16:10 Coffee/tea break
BRET2 assays in industry and academia
Anders Heding (7TM Pharma, Denmark)
Interaction between the beta2-adrenergic receptor and arrestin is dependent on both receptor phosphorylation and the presence of agonists
Cornelius Krasel (Wuerzburg, Germany)
17:30 - 19:00 Drinks Reception
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