Organizers:
Dominic Walsh (University College Dublin, Republic of Ireland)
Veronica Campbell (Trinity College Dublin, Republic of Ireland)
Maria Fitzgibbon (Trinity College Dublin, Republic of Ireland)
Brent Irvine (Queen's University Belfast, Northern Ireland)
Tim Lynch (University College Dublin, Republic of Ireland)
Janet Johnston (Queen's University Belfast, Northern Ireland)
Cora O'Neill (University College Cork, Republic of Ireland)
Michael Farrell (Royal College of Surgeons in Ireland, Dublin, Republic of Ireland)
Timetable
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Plenary Session 1
Chairs:
Cora O'Neill (University College Cork, Republic of Ireland)
Christian Haass (Munich, Germany)
Disease modifying therapies for the treatment of Alzheimer¿s disease targeted at modulating levels of the amyloid-b peptide
Menelas Pangalos (Wyeth Research, Madison, NJ, USA)
Ab-APP interactions and neuronal cell death
Edward Koo (California, CA, USA)
Wim Annaert (Leuven, Belgium)
10:45 - 11:15 Coffee/tea break
The molecular basis of memory failure in Alzheimer¿s disease
Dennis Selkoe (Harvard, MA, USA)
Tau aggregation and tau aggregation inhibitors
Eckhard Mandelkow (Max Planck Unit for Structural Biology, Hamburg, Germany)
Immunization against b-amyloid in Alzheimer's disease
Roger Nitsch (Zurich, Switzerland)
13:05 - 15:00 Lunch and poster session
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Open Session - Basic Science
Chairs:
Caroline Herron (University College Dublin, Republic of Ireland)
Roger Nitsch (Zurich, Switzerland)
Regulation of gene expression and cell death by the amyloid precursor protein
Jochen Prehn (Royal College of Surgeons of Ireland, Dublin, Republic of Ireland)
Synaptic plasticity disruption by amyloid ß protein: mechanisms and modulation
Michael Rowan (Trinity College Dublin, Republic of Ireland)
Presenilins involvement in signal transduction pathways
Justin McCarthy (University College Cork, Republic of Ireland)
Mechanisms of memory consolidation as therapeutic targets
Ciaran Regan (University College Dublin, Republic of Ireland)
The effects of presenilin2 mutation and inhibition of g-secretase on p75NTR signalling
Stephen McIlroy (Queen's University of Belfast, Northern Ireland)
Is the increased susceptibilty of the aged brain to insult associated with inflammatory changes?
Marina Lynch (Trinity College Dublin, Republic of Ireland)
17:30 - 18:30 Poster Session
Poster prizes to be awarded, judged by Janet Johnston and John Hardy
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Plenary Session 2
Chairs:
Brent Irvine (Queen's University Belfast, Northern Ireland)
Edward Koo (California, CA, USA)
The g-secretase complex : issues and opportunities
Mark Shearman (Merck Sharp & Dohme Research Laboratories, UK)
g-secretase complex assembly and function
Christian Haass (Munich, Germany)
Genetic dissection of the etiologies and pathogeneses of Alzheimer¿s and Parkinson¿s diseases and related disorders
John Hardy (National Institutes of Health, Bethesda, MD, USA)
10:45 - 11:15 Coffee/tea break
Pathophysiology, pleiotrophy and paradigm shifts: genetic lessons from Parkinson's disease
Matt Farrer (Mayo Clinic, Jacksonville, FL, USA)
Mechanisms of memory loss in Ab and tau Alzheimer mouse models
Karen Ashe (Minnesota, MN, USA)
b-secretase and disease modification
Martin Citron (Amgen Inc, Thousand Oaks, CA, USA)
13:05 - 15:00 Lunch and poster session
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Open Session - Clinical
Chairs:
Tim Lynch (University College Dublin, Republic of Ireland)
Karen Ashe (Minnesota, MI, USA)
Video-based presentation on the neuropsychiatric syndromes of Alzheimer's disease
Brian Lawlor and Robert Coen (Mercer's Institute of Research on Ageing (MIRA), Dublin, Republic of Ireland)
The effects of A b immunization on the neuropathology of Alzheimer¿s disease
James Nicoll (Southampton, UK)
Video based presentations of Parkinsonism - including idiopathic PD and familial PD (Parkin, DJ-1, PINK)
Mark Gibson and Tim Counihan (Belfast City Hospital, Northern Ireland and University College Hospital Galway)
The clinicopathological features of the tauopathies
Brian Murray and Michael Farrell (Mater Hospital Dublin & Royal College of Surgeons in Ireland, Dublin, Republic of Ireland)
Panel Question and Answer Session
17:50 - 18:50 Poster Session
Poster prizes to be awarded, judged by Veronica Campbell and Wim Annaert
19:30 Government Hosted State Reception (pre-reserved tickets only)
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Satellite Symposium
Chairs:
Ingrid Allen (Queen's University Belfast, Northern Ireland)
Mark Rogers (University College Dublin, Republic of Ireland)
Welcome and introductory remarks on neurodegeneration research in Ireland
Ingrid Allen (Queen's University Belfast, Northern Ireland)
Harnessing chaperones to generate potent small molecule inhibitors of amyloid b aggregation
Isabella Graef (Stanford, CA, USA)
The production of hydrogen peroxide during early-stage protein aggregation - a common pathological mechanism in different neurodegenerative diseases
David Allsop (Lancaster, UK)
ADDL-directed therapeutics for treatment of Alzheimer¿s disease and related memory disorders
Grant Krafft (Acumen Pharmaceuticals, Inc., USA)
Tau and Alzheimer's disease: role in axonal traffic and APP transport
Eva-Maria Mandelkow (Max Planck Unit for Structural Biology, Hamburg, Germany)
The secretases as therapeutic targets in Alzheimer's disease
Bart DeStrooper (Leuven, Belgium)
Molecular chaperones - as therapeutic targets in ALS
Linda Greensmith (Institute of Neurology, London, UK)
Ab oligomers and their cognitive effects
Jim Cleary (Veterans Affairs Medical Center, Minneapolis, MN, USA)
18:15 - 19:15 Welcome Drinks Reception sponsored by Trinity College Institute of Neuroscience
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