Chair:
David Smith (MRI/University of Glasgow)
Organizers:
Jean-Michel Sallenave (MRC Centre for Inflammation Research, Edinburgh, UK)
John Govan (University of Edinburgh, UK)
08:45 - 09:40 Registration and coffee/tea
09:40 - 09:45 Welcome and introduction
Structural and functional studies of defensin-inspired peptides
Dominic Campopiano (University of Edinburgh, UK)
beta-defensin evolution: selection complexity and clues for residues of functional importance
Julia Dorin (MRC Human Genetics Unit, Edinburgh, UK)
Paneth cell defensins: key effector molecules of innate immunity
Charles Bevins (University of California - Davis, USA)
12:00 - 13:30 Lunch and poster session
Characterisation of the antimicrobial and antiprotease activities of AWAP IV
Selected oral communication - Claire Townes (University of Newcastle upon Tyne, UK)
¿Birth-and-Death¿ evolution of the mammalian beta-defensin loci on chromosome 20
Selected oral communication - Ed Hollox (University of Nottingham, UK)
The mechanism of specific interaction between sushi peptides and bacterial membrane lipid mimics: structure-activity relationship
Selected oral communication - Li Peng (National University of Singapore, Singapore)
Inhibition of antimicrobial peptides by Group A Streptococci: M1 SIC and M12 drs
Peter Lachman (University of Cambridge, UK)
15:00 - 15:20 Coffee/tea break
Antimicrobial peptides in inflammatory lung disease
Pieter Hiemstra (Leiden University, The Netherlands)
Antimicrobial molecules as adjuvant molecules for adaptive immunity
Jean-Michel Sallenave (MRC Centre for Inflammation Research, Edinburgh, UK)
Manipulation of dendritic cells for host defense against intracellular infections
Zhou Xing (McMaster University, Canada)
17:40 - 18:40 Wine reception