Organizers:
Mark Wheatley (University of Birmingham, UK)
David Poyner (University of Aston, UK)
Timetable
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Ligand Binding
09:00 - 10:00 Registration
10:00 - 10:15 Welcome and introduction by Organizers
Secretin receptor structure and mechanism of activation
Laurence Miller (Mayo Clinic, USA)
Identifying residues involved in selective peptide binding at Family B GPCRs
Dan Donnelly (University of Leeds, UK)
A fine line between agonism and antagonism at chemokine receptor CCR3
Selected oral communication - Emma Wise (Imperial College London, UK)
Extracellular loops and ligand binding to Family A GPCRs
Mark Wheatley (University of Birmingham, UK)
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Activation of Family B GPCRs
Structural characterization of ligand binding and activation of the parathyroid hormone receptor
Dale Mierke (Brown University, USA)
14:50 - 15:20 Coffee/tea break
Visualization of differential conformational changes within the 3rd intracellular loop of the alpha2A-adrenergic receptor for full and partial agonists by optical recording in living cells
Selected oral communication - Carsten Hoffman (University of Würzburg, Germany)
Molecular mechanisms involved in activation and regulation of the vasoactive intestinal peptide receptors: current knowledge, similarities and differences with the A family of G protein coupled receptors
Ingrid Langer (University of Brussels (ULB), Belgium)
Ligand binding and activation of the CGRP receptor
David Poyner (University of Aston, UK)
Extracellular loop flexibility and ligand binding: lessons from the M2 muscarinic receptor
Patrick Sexton (Monash University, Australia)
17:35 - 19:00 Poster session
19:00 - 21:00 Meeting dinner
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Receptor theory
Mechanisms underlying agonist efficacy
Philip Strange (University of Reading, UK)
Neurotensin Receptor 1: E.coli expression, purification, characterisation and biophysical studies
Selected oral communication - Peter Harding (University of Oxford, UK)
Crystal structure of a rhodopsin stabilizing mutant expressed in mammalian cells
Gebhard Schertler (Medical Research Council, UK)
Differential orexin receptor internalization and recycling kinetics attributed to distinct beta-arrestin interactions
Selected oral communication - Kevin Pfleger (Western Australian Institute for Medical Research, Australia)
10:50 - 11:20 Coffee/tea break
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Activation of Family A GPCRs
Coupling selectivity of the human oxytocin receptor
Bice Chini (CNR Institute of Neuroscience, Italy)
Phenotypic classification of mutants: A tool for understanding ligand binding and activation of muscarinic acetylcholine receptors
Ed Hulme (National Institute for Medical Research, UK)
Novel cell based assay approaches to monitor GPCR activation
Richard Eglen (PerkinElmer, USA)
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Mutual mechanisms?
A novel ß-arrestin assay for monitoring GPCR activation
Selected oral communication - Anne Fowler (DiscoveRx, UK)
The MC4 receptor: organisation, ligand binding and activation
John Findlay (University of Leeds, UK)
Computational studies of class A and class B GPCRs
Christopher Reynolds (University of Essex, UK)
15:55 - 16:15 Summary and closing remarks from Organizers
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