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Regulation of protein function by SUMO modification

25—27 June 2007

Manchester Conference Centre, UK



Organizers:
Andy Sharrocks (University of Manchester, UK)
Ron Hay (University of Dundee, UK)

Timetable

Monday 25 June 2007Tuesday 26 June 2007Wednesday 27 June 2007
17:10 - 18:30
The SUMO pathway machinery

09:00 - 10:40
In vivo roles of SUMO

11:10 - 13:00
SUMO and nuclear functions (1)

15:30 - 17:10
SUMO and nuclear functions (2)

09:00 - 10:30
Specificity and regulation of Sumoylation (1)

11:00 - 12:40
Specificity and regulation of Sumoylation (2)


The SUMO pathway machinery

Chair:
Hugues de The (University of Paris, France)
Monday 25 June 2007
15:00 - 17:00 Registration

17:00 - 17:10 Opening address by Andy Sharrocks

17:10 - 17:40
Role of SUMO modification in the control of gene expression
Ron Hay (University of Dundee, UK)
17:40 - 18:10
Regulation of E2 function by SUMO
Titia Sixma (Netherlands Cancer Institute, The Netherlands)
18:10 - 18:30
SUMO-1, SUMO-2 and SUMO-3 polymerize in vivo via the internal sumoylation sites of SUMO-2 and SUMO-3
Selected oral communication - Alfred Vertegaal (Leiden University Medical Center, The Netherlands)
18:30 - 20:30 Welcome reception with buffet

In vivo roles of SUMO

Chair:
Titia Sixma (Netherlands Cancer Institute, The Netherlands)
Tuesday 26 June 2007
09:00 - 09:30
Role of SUMO modification in cellular senescence and telomere maintenance
Anne Dejean (Pasteur Institute, France)
09:30 - 09:50
SUMO Modification of Httex1p in HD pathogenesis
Selected oral communication - Jacqueline Gire (UC Irvine, USA)
09:50 - 10:10
Sumoylation dependent function of a T-box transcriptional repressor in C. elegans
Selected oral communication - Peter Okkema (University of Illinois, Chicago, USA)
10:10 - 10:40
Role of sumolation in APL pathogenesis and therapy response
Hugues de The (University of Paris, France)
10:40 - 11:10 Coffee/tea break

SUMO and nuclear functions (1)

Chair:
Hsiu-Ming Shih (Academia Sinica, Taiwan)
Tuesday 26 June 2007
11:10 - 11:40
The role of SUMO ligases in genome tability in S. pombe
Felicity Watts (University of Sussex, UK)
11:40 - 12:10
Control of DNA replication and damage bypass by SUMO and ubiquitin
Helle Ulrich (Cancer Research UK, UK)
12:10 - 12:30
Dissecting the SUMOylation pathway in DT40
Selected oral communication - Kevin Hiom (MRC Laboratory of Molecular Biology, UK)
12:30 - 13:00
Regulation of epigenetic gene silencing by SUMO and PIAS proteins
Irina Stancheva (University of Edinburgh, UK)
13:00 - 15:30 Lunch and poster session

SUMO and nuclear functions (2)

Chair:
Jorma Palvimo (University of Kuopio, The Netherlands)
Tuesday 26 June 2007
15:30 - 16:00
Regulation of the dual function transcription factor Sp3 by SUMO modification
Grace Gill (Tufts University School of Medicine, USA)
16:00 - 16:20
Sumoylation of the RNA helicase p68 and its role in transcriptional regulation
Selected oral communication - Frances Fuller-Pace (University of Dundee, UK)
16:20 - 16:50
Daxx mediates SUMO-dependent transcriptional control and subnuclear compartmentalization
Hsiu Ming Shih (Academia Sinica, Taiwan)
16:50 - 17:10
Regulation of MOT1 by SUMO modification and SLX5/SLX8 in Saccharomyces cerevisiae
Selected oral communication - Greg Prelich (Albert Einstein College of Medicine, USA)

Specificity and regulation of Sumoylation (1)

Organizer:
Susanna Chiocca (European Institute of Oncology, Italy)
Wednesday 27 June 2007
09:00 - 09:30
Pc2 regulates sumoylation and Akt-dependent phosphorylation of CtBP
David Wotton (University of Virginia, USA)
09:30 - 10:00
Regulation of transcription factors by PIAS proteins
Jorma Palvimo (University of Kuopio, Finland)
10:00 - 10:30
Specificity and regulation of sumoylation in gene transcription
Lea Sistonen (Turku Centre for Biotechnology, Finland)
10:30 - 11:00 Coffee/tea break

Specificity and regulation of Sumoylation (2)

Chair:
Grace Gill (Tufts University School of Medicine, USA)
Wednesday 27 June 2007
11:00 - 11:30
Dynamic interactions between the SUMO pathway and other post-translational modifications
Andy Sharrocks (University of Manchester, UK)
11:30 - 11:50
Identification of constitutive and induced SUMOylation and analysis of its function using the Ubc9 fusion-directed SUMOylation (UFDS) system
Selected oral communication - Rainer Niedenthal (Hannover Medical School, Germany)
11:50 - 12:10
Sumoylation of papillomavirus E2 proteins
Selected oral communication - Van Wilson (Texas A&M University, USA)
12:10 - 12:40
Viral control of the SUMO pathway
Susanna Chiocca (European Institute of Oncology, Italy)
12:40 - 13:00 Closing remarks by Ron Hay