Organizers:
Mike Sutcliffe (University of Manchester, UK)
Mike Williamson (University of Sheffield, UK)
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Session 1
10:00 - 11:30 Registration with tea and coffee
Evolution and assembly of protein complexes
Plenary lecture - Sarah Teichmann (MRC Laboratory of Molecular Biology, UK)
12:30 - 12:45 Semantic Biochemical Journal presentation
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Session 2
Study of protein complexes using Tandem Affinity Purification-Mass Spectrometry
Pierre-Olivier Angrand (CNRS, France)
Calorimetry as a tool for understanding biomolecular interactions and an aid in drug design
John Ladbury (M. D. Anderson Cancer Center, USA)
Molecular architecture of the stressosome, a signal integration and transduction hub
Selected oral communication - Richard Lewis (Newcastle University, UK)
Selectivity in a barren landscape: The P450BioI-ACP complex
Selected oral communication - Max Cryle (Max-Planck Institute for Medical Research, Germany)
15:10 - 15:40 Coffee/tea break
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Session 3
Protein: protein interactions of complement factor H using a multidisciplinary strategy
Steve Perkins (University College London, UK)
Insight into protein:protein interactions from analytical ultracentrifugation
Stephen Harding (University of Nottingham, UK)
Inducible protein dimerisation for signal transduction
Selected oral communication - Dominik Erhart (University of Basel, Switzerland)
17:00 - 19:00 Poster Session 1 and networking event
19:30 - 22:00 Conference dinner at Firth Hall
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Session 4
Synchrotron Radiation Circular Dichroism (SRCD) Spectroscopy - A new method for examining protein conformations and protein:protein interactions
Bonnie Wallace - AstraZeneca Award lecture (University of London, UK)
Information-driven modelling of biomolecular complexes
Alexandre Bonvin (Utrecht University, The Netherlands)
Protein-Protein interaction using isotope-edited Fourier transform infrared spectroscopy
Selected oral communication - Parvez Haris (De Montfort University, Leicester, UK)
10:40 - 11:10 Coffee/tea break
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Session 5
Optimising expression of mammalian proteins for interaction studies
Michael Dyson (University of Cambridge, UK)
Complexes of ceruloplasmin with proteins of neutrophils and their probable biochemical roles
Selected oral communication - Vadim Vasilyey (Institute for Experimental Medicine, Saint-Petersburg, Russia)
Probing protein interactions using single molecule fluorescence
David Klenerman (University of Cambridge, UK)
12:30 - 13:30 Lunch and Poster Session 2
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Session 6
Large-scale screening for novel low affinity extracellular protein interactions
Gavin Wright (The Wellcome Trust Sanger Institute, UK)
Proteomic Complex Detection using Sedimentation (ProCoDeS): A methodology for identification of proteins in complexes
Paul Dupree (University Of Cambridge, UK)
14:30 - 14:40 Presentation of the poster prize
14:40 - 15:15 General discussion and concluding remarks
15:15 Coffee/tea break and close of meeting
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