Organizers:
Timothy Thomson (IBMB-CSIC, Barcelona, Spain)
Bernat Crosas (IBMB-CSIC, Barcelona, Spain)
Gemma Marfany (University of Barcelona, Spain)
Rosa Farràs (Prince Felipe Research Centre (CIPF), Spain)
Manuel Rodríguez (CICbioGUNE–CIBERhed, Spain)
Timetable
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Session I: Mechanisms of specificity regulating the Ubiquitin-Proteasome System
Chair:
Alfred Vertegaal (Leiden University Medical Center, The Netherlands)
08:00 - 09:00 Registration
09:00 - 09:15 Welcome and introduction from the organizers
Chaperone-mediated assembly of the proteasome RP
Daniel Finley (Harvard Medical School, USA)
Regulation of gate opening into the 20S proteasome
Alfred Goldberg (Harvard Medical School, USA)
Regulation of the ubiquitin receptor Rpn10 by monoubiquitination
Bernat Crosas (IBMB-CSIC, Barcelona, Spain)
The assembly pathway of the 19S regulatory particle of the proteasome
Anne Peyroche (Institute of Biology Technologies, France)
11:05 - 11:30 Coffee/tea break
Chaperone-assisted assembly of the proteasome core particle
Juergen Dohmen (University of Cologne, Germany)
A family of ubiquitin conjugating enzymes involved in plant cell death regulation senses oxidative signals
Karolin Eifler (University of Vienna, Austria)
The UBA-UIM domains of USP25 regulate the enzyme ubiquitination state and modulate substrate recognition
Gemma Marfany (University of Barcelona, Spain)
Differential Ufd2-binding properties of budding yeast UBL-UBA proteins Rad23 and Dsk2 adds up to their functional diversity
Shahri Raasi (University of Konstanz, Germany)
Versatile use of Tandem Ubiquitin Binding Entities (TUBEs) for the functional characterisation of ubiquitin-regulated macromolecular complexes
Fabienne Aillet (CICbioGUNE–CIBERhed, Spain)
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Session II: SUMO-regulated processes
Chair:
Bernat Crosas (IBMB-CSIC, Barcelona, Spain)
Control of promyelocytic leukaemia protein metabolism by SUMO
Ron Hay (University of Dundee, UK)
Two functionally non-equivalent Ubc9 molecules in the RanBP2 SUMO E2/E3 ligase
Frauke Melchior (University of Göttingen, Germany)
Crosstalk between SUMO-2/3 and the ubiquitin-proteasome system
Alfred Vertegaal (Leiden University Medical Center, The Netherlands)
SIRT1 stabilizes PML through sumoylation and protects against viral infection
Michela Campagna (Universidad Autónoma de Madrid, Spain)
16:50 - 17:15 Coffee/tea break
Sumoylation modulates Spalt activity
Rosa Barrio (CICbioGUNE, Spain)
SUMO activation as a regulatory step in the conjugation cascade
Maria Lois (University of Barcelona, Spain)
Double-strand break repair: chromosome behaviour and regulation by SUMO
Stefan Jentsch (Max Planck Institute of Biochemistry, Germany)
18:30 - 21:00 Poster session 1 and welcome cocktails reception
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Session III: Ubiquitin and the cell cycle
Chair:
Olivier Coux (CRBM-CNRS, Montpellier, France)
Genetic and proteomic analysis of the ubiquitin system
Wade Harper (Harvard Medical School, USA)
Chaining ubiquitin to the spindle
Michael Rape (University of California at Berkeley, USA)
Control of mammalian development and cell proliferation by the Anaphase Promoting Complex (APC/C) ubiquitin ligase
Marcos Malumbres (Centro Nacional de Investigaciones Oncológicas (CNIO) Madrid, Spain)
Roles for Cks in APC/C-Cdc20-dependent destruction of cyclin A and cyclin B1
Rob Wolthuis (The Netherlands Cancer Institute, The Netherlands)
10:50 - 11:15 Coffee/tea break
Protection by protein binding - a novel mechanism for synchronized degradation
Michael Brandeis (The Hebrew University of Jerusalem, Israel)
Degradation of cyclin A is regulated by acetylation
Miriam Vidal-Laliena (University of Barcelona, Spain)
Regulation of Aurora kinase B by the lipid raft protein Flotillin-1
Rosanna Paciucci (Institut de Recerca Hospital Vall d’Hebrón Barcelona, Spain)
MPF and MAPK are required for inhibiting premature destruction of securin by APC/Cdh1 in mouse oocytes
Ibtissem Nabti (University College London, UK)
Beta-TrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis
Michele Pagano (New York University School of Medicine, USA)
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Session IV: Ubiquitin and DNA damage repair
Chair:
Gemma Marfany (University of Barcelona, Spain)
RNF8 and RNF168 define orchestrate the response to DNA double-strand breaks
Dan Durocher (University of Toronto, Canada)
The role of ubiquitination in DNA damage response: proteomic analysis to identify new DNA-damage induced ubiquitinated proteins
Jogitha Selvarajah (St George’s University of London, UK)
The Gid-E3 and Cdc48 machines are central components in ubiquitin-proteasome triggered regulation of carbohydrate metabolism in yeast
Lise Barbin (University of Stuttgart, Germany)
BRCA1 activity is regulated by the SUMO modification pathway in response to genotoxic stress
Jo Morris (King’s College London, UK)
16:35 - 17:00 Coffee/tea break
Cross-talks between ubiquitylation and acetylation in the regulation of p53
Olivier Coux (CRBM-CNRS, Montpellier, France)
Control of PCNA deubiquitylation in yeast
Avelino Bueno (University of Salamanca-CSIC, Spain)
REV7-mediated polyubiquitination and degradation of human REV1
Abel Chun (The University of Hong Kong, Hong Kong)
Ubiquitylation in DNA damage signalling, checkpoint control, and relevance to cancer
Jiri Bartek (Danish Cancer Society, Denmark)
18:35 - 21:00 Poster session 2
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Session V: Drug discovery in UPS
Chair:
Alfred Goldberg (Harvard Medical School, USA)
Chemistry of ubiquitination, proteolysis and antigen presentation
Huib Ovaa (Netherlands Cancer Institute, The Netherlands)
A genome-wide siRNA screen for modulators of bortezomib-induced cell death
Eric Lightcap (Millennium Pharmaceuticals, Inc., Cambridge, USA)
Development of a high-throughput assay to profile proteasome inhibition and activation in live cells
Celia Berkers (Netherlands Cancer Institute, The Netherlands)
Observations and insights into the mechanisms of Ub and Ubl activating enzymes
James Gavin (Millennium: The Takeda Oncology Company, USA)
Discovery of novel proteasome inhibitors, using a high-content cell-based screening system
Irena Lavelin (Weizmann Institute of Science, Israel)
10:55 - 11:20 Coffee/tea break
A comprehensive approach for detecting inhibitors of the therapeutic target USP7
Seth Goldenberg (Progenra, Inc, Malvern, USA)
Recent progress towards the identification of selective inhibitors of ubiquitin specific proteases
Frédéric Colland (Hybrigenics Pharma, Paris, France)
Live imaging and quantification of proteasome activity in C. elegans
Olli Matilainen (University of Helsinki, Finland)
Targeting ubiquitin networks
Ivan Dikic (Goethe University Medical School, Germany)
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Session VI: Ubiquitin and UBL in intracellular traffic
Chair:
Timothy Thomson (IBMB-CSIC, Barcelona, Spain)
15:00 - 17:25 Poster session 3
How ubiquitin controls EGFR endocytosis and fate
Sara Sigismund (The FIRC Institute for Molecular Oncology, Italy)
A late domain-based pathway plays a key role during virus entry
Harald Wodrich (University of Bordeaux 2, France)
Parkin-mediated K63-linked polyubiquitination targets misfolded proteins to the aggresome-autophagy pathway
Lih-Shen Chin (Emory University School of Medicine, Atlanta, USA)
The novel Alzheimer's disease-associated protein ubiquilin-1 regulates presenilin-1 aggregation and formation of aggresomes
Annakaisa Haapasalo (University of Kuopio, Finland)
COP9 signalosome controls signal functions in the NF-kB system
Katrin Schweitzer (Otto von Guericke University, Germany)
Conclusions and farewell remarks
Manuel Rodríguez (CICbioGUNE–CIBERhed, Spain)
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