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Future Events > Determination of Binding Affinities and Molecular Mechanisms

Determination of Binding Affinities and Molecular Mechanisms

2 May 2014

Charles Darwin House, London, UK



A Biochemical Society Training Day

 

Biochemical Society Training Days are designed to address a specific scientific training need within the bioscience community, aimed at PhD level and beyond. These events aim to create a platform for participants to gain hands-on experience, and an opportunity to ask questions and discuss problems with experts in the field.

 

Scientific background

 

This Training Day will focus on the analysis of biochemical equilibrium binding data, with the goal to determine the underlying molecular mechanism and the corresponding binding constants.  All mathematical models are automatically derived by the free software package DynaFit.  Participants will solve practical problems from published literature or generated in their own laboratories.

 

Attendance is by application only, and places are limited.

 

Application deadline: Application has now closed.

If you wish to apply to attend this Training Day, please contact the Conference Office.

 

 

Topics

  • Single-site and multiple-site binding 
  • Co-operativity 
  • Competitive displacement 
  • Thermodynamic cycles 
  • Statistical factors 
  • D-Optimal experimental design  
  • Confidence intervals for binding constants
  • Monte Carlo methods 
  • "Differential Evolution" global fit
  • Binding  model selection: Bayesian and Akaike information Criteria