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Regulation in Metabolism Group
The Regulation in Metabolism Group exists to organize meetings which promote
a better understanding of the regulation and control of biological processes
at the biochemical level. This encompasses diverse areas such as
nutrient utilsation and energy conversions, cell signalling in health and
disease and cell and protein structure and function. As such our
aims overlap with numerous other interest groups within the Society which
is reflected in the number of colloquia which we organize jointly
with these other committees. From time to time we also hold symposia with
other societies such as The Nutrition
Society and The
Physiological Society.
Committee and AGM
Recent and forthcoming colloquia:
Research Interests and Biographical Details of
Committee Members
What we are about!
New Avenues of Research in Fatty Acid Oxidation and Ketone Body Metabolism: the scientific legacy of Derek Williamson
Committee members:
| Mike Titheradge (Chair) |
University of Sussex E-mail:
m.a.titheradge@sussex.ac.uk |
| David Tosh (Secretary) |
University of Bath E-mail: bssdt@bath.ac.uk |
| Simon Eaton |
Institute of Child Health, London. E-mail: s.eaton@ich.ucl.ac.uk |
| John Harwood |
University of Cardiff, Wales, E-mail: Harwood@cardiff.ac.uk |
| David Fell |
Oxford Brookes University, E-mail: daf@brookes.ac.uk |
| Phill Hawkins |
The Babraham Institute, Cambridge E-mail: Phillip.Hawkins@bbsrc.ac.uk |
| Brendan Leighton |
Zeneca, Alderley Edge, E-mail: brendan.leighton@astrazeneca.com |
| Jennifer Rivett |
University of Bristol, E-mail: j.rivett@bristol.ac.uk |
| Victor Zammit |
Hannah Research Institute, Ayr, Scotland E-mail: ZammitV@main.hri.sari.ac.uk |
AGM
The date for the 2001 AGM will be announced soon.
Recent and forthcoming colloquia
Organisms, Organs, Cells and Organelles: in vivo and in vitro experimental
systems (Joint with Molecular
Enzymology Group) Cork 7th-9th September 1999
Research Interests and Biographical Details of
Committee Members
Dr Phillip Hawkins is a Lecturer at the Babraham
Institute, Cambridge. His research interests include: intracellular signalling
pathways in mammalian cells; inositol phospholipids, inositol phosphates
and the phosphoinositide 3-kinase (P13K) signalling pathway. The
Babraham Institute, Babraham, Cambridge, CB2 4AT. Tel: 01223 496598
Fax: 01223 496043 E-mail: Phillip.Hawkins@bbsrc.ac.uk
Dr David Tosh is a Lecturer in the Department of
Biology and Biochemistry at the University of Bath. His research
interests are currently centred on elucidating the cellular and molecular
mechanisms underlying pancreas and liver development. School
of Biology and Biochemistry, University of Bath, Claverton Down, Bath
BA2 7AY, Telephone: +44 1225 826532FAX: +44 1225 826449 or 826779 E-mail:
bssdt@bath.ac.uk
Dr Mike Titheradge is Senior Lecturer in the
School of Biological Sciences, University of Sussex. His research
interests are : Regulation of hepatic carbohydrate metabolism; liver
metabolism in septic shock; nitric oxide and the liver. School
of Biological Sciences, University of Sussex, Falmer, Brighton, BN1
9QG. Tel. 01273 678742, Fax 01273 678433. Email: m.a.titheradge@sussex.ac.uk
Dr Simon Eaton is a Non-Clinical Lecturer in the
Unit of Paediatric Surgery, Institute of Child Health, London. His research
interests are: intramitochondrial control of beta-oxidation, development
of beta-oxidation, and oxidative metabolism in neonatal sepsis. Institute
of Child Health, University College, 30 Guilford Street, London, WC1N
1EH. Telephone : +44 (0)20 79052158 Fax: +44 (0)20 7404 6181 E-mail: s.eaton@ich.ucl.ac.uk
Dr Victor Zammit is Senior Principal Research Scientist
at the Hannah Research Institute, Ayr, Scotland. His Research Aims are:
elucidation of the mechanisms through which the liver contributes different
substrates for utilisation by peripheral tissues, including the partitioning
of fatty acids between oxidation to ketone bodies and acylglyceride synthesis,
and the involvement of different signal transduction systems in the control
of these and the cholesterogenic pathway. Hannah
Research Institute, Ayr, Scotland, KA6 5HL. Telephone +44 1292 674058,
Fax +44 1292 674004 E-mail: ZammitV@hri.sari.ac.uk
Prof. John Harwood is Head of the Environmental
Biochemistry and Microbiology research group at the University of Cardiff.
John Harwood has research interests on the regulation of metabolism of
acyl lipids. These interests concentrate on plant lipids, especially the
role of the environment in changing metabolism. However, environmental
factors such as temperature, xenobiotics and heavy metals are being investigated
in relation to other organisms. Medical topics include lung surfactant
and infammatory responses. Regulation is being studied by flux control
analysis of whole systems, at the enzyme level and in relation to changed
gene expression. Cardiff
School of Biosciences, PreClinical Building, Cardiff University, PO
Box 911, Cardiff, Wales, CF1 3US. Telephone : +44 1222 874108, Fax: + 44
1222 874116 E-mail: Harwood@cf.ac.uk
Dr Brendan Leighton is a Team Leader in the CardioVascular
& GastroIntestinal Discovery Department at AstraZeneca. His research
interests include: understanding the mechanisms underlying the development
of insulin resistance in skeletal muscle; the role of nitric oxide/cGMP
in regulating carbohydrate metabolism in muscle; in vivo analysis of mechanisms
of action of drugs that lower blood glucose concentrations. AstraZeneca
Pharmaceuticals, 3S36, Mereside, Macclesfield, SK10 4TG, Telephone: +44
1625 515766 Fax: +44 1265 517738 E-mail: brendan.leighton@astrazeneca.com
Professor David Fell is Deputy Head of the School
of Biological and Molecular Sciences at Oxford Brookes University. The
unifying theme in his research is the attempt to understand the general
principles governing the organization, regulation and control of metabolism.
This involves the development and application of suitable theoretical tools:
metabolic control analysis, computer simulation and other forms of algebraic
and numerical analysis. Potential applications are the rational design
of changes in metabolism (metabolic engineering) and improved understanding
of how hormonal and environmental signals can cause large changes in specific
metabolic processes with minimal other disruption to the cell. He is author
of "Understanding
the Control of Metabolism" published by Portland Press. School
of Biological and Molecular Sciences, Oxford Brookes University, Headington,
Oxford, OX3 0BP Telephone +44 (0)1865 483247 Fax: +44 (0)1865 484017
Dr. A. Jennifer Rivett is Reader in Biochemistry
in the Department of Biochemistry, Univeristy of Bristol. Her research
interests centre on proteasomes. Proteasomes are the major nonlysosomal
proteolytic machinery of eukaryotic cells. They are found in the nucleus
and in the cytoplasm and play a key role in the degradation of regulatory
proteins (including cyclins and transcription factors). Department
of Biochemistry, Univeristy of Bristol., University Walk, Bristol,
BS8 1TD Tel: (0117) 928 8929 E-mail: j.rivett@bristol.ac.uk
Details about Publication of the Proceedings
of the Sussex Fatty Acid Oxidation & Ketone Body Metabolism Meeting.
We are intending to publish all the proceedings from the meeting, including
the Pre-Doctoral day. Speakers from the main meeting will be published
as usual in Biochemical
Society Transactions. In addition, we are intending to publish
all presenters of posters from both the main meeting and the predoctoral
day and presenters of talks from the predoctoral day. The deadline for
submission of manuscripts is 31st January 2001, please contact E-mail:
s.eaton@ich.ucl.ac.uk if you
would like further details.
What we are about!
Any suggestions or enquiries about this page, please e-mail s.eaton@ich.ucl.ac.uk
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