University of Glasgow Meeting, 7-9 April 1999
Themed Meeting, centred around: "Complex Protein Assemblies as Molecular Machines"
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Meeting Programme
Wednesday 7 April/ Thursday 8 April/ Friday 9 April 1999
Regulation in Metabolism Group/ Membrane Group colloquium:
Phospholipids: regulators of membrane traffic and signalling
- Sponsors:
- Echelon Research Laboratories
- Eli Lilly & Co
- The Gatsby Charitable Foundation
- Merck Sharpe & Dohme
- Novartis
- SmithKline Beecham
- Unilever
- Yamanouchi
- Zeneca
- Organisers:
- S. Cockcroft (London)
- P. Hawkins (Cambridge, UK)
Wednesday 7 April
Lipids as targetting devices
- Chair:
- B. Michell (Birmingham)
- Speakers:
- 09.00 B. Michell (Birmingham)
- Chair's Introduction
- The Philip Godfrey Memorial Lecture
- 09.20 B. Hemmings (Basel)
- PH domains in cell signalling
- 09.50 T. Meyer (North Carolina)
- Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals
- 10.30 Coffee
- 11.00 Society Medal Lecture
- 12.10 M. Lemmon (Philadelphia)
- Structural bases for specific phosphoinositide binding by PH domains
- 12.50 Lunch
Cellular functions of PIP3
- Chair:
- P. Hawkins (Cambridge)
- Speakers:
- 13.50 D. Alessi (Dundee)
- Insulin signalling downstream of PI 3-kinase
- 14.30 D. Fruman (Harvard)
- PI 3-kinase gene knockouts
- 15.10 S. Watton (London)
- Localisation of Akt and 3' phosphoinositides
- 15.50 M. Wymann (Fribourg)
- PI 3-kinase signalling - no lipids
- 16.30 Poster Session
- 17.30 Membrane Group Committee Meeting
- 18.15 Membrane Group AGM
Thursday 8 April
Lipids in vesicle formation and consumption
- Chair:
- S. Cockcroft (London)
- 09.00 F. Wieland (Heidelberg)
- Biogenesis of COP1-vesicles: proteins and mechanisms
- 09.40 W. Huttner (Heidelberg)
- Lipid-protein interactions in the biogenesis of neurosecretory granules and vesicles
- 10.20 Coffee
- 11.00 Society Medal Lecture
- 12.10 N. Ktistakis (Cambridge, UK)
- Intracellular transport and organelle morphology in cell lines with inducible overexpression of PLD1, or of a PLD1-derived anti-sense fragment
- 12.50 M. De Matteis (Chieti, Italy)
- ARF regulates spectrin-skeleton assembly on the Golgi complex by stimulating PIP2 synthesis
- 13.40 Lunch and Regulation in Metabolism Group Committee Meeting
PIP2 functions
- Chair:
- W. Huttner (Heidelberg)
- 14.40 S. Cockcroft (London)
- ARF-regulated phospholipase D in membrane traffic
- 15.20 G. Schiavo (London)
- Phosphoinositides and neurotransmitter release
- 16.00 H. Yagisawa (Hyogo)
- PLC-delta and related molecules
- 16.40 R. Irvine (Cambridge, UK)
- The regulation of type II PIPkins (PI4P 5-kinases)
- 17.20 Poster Session
Friday 9 April
Cellular functions of PI3P in traffic
- Chair:
- B. Hemmings (Basel)
- 09.00 M. Clague (Liverpool)
- Regulation of endosome fusion
- 09.40 H. Stenmark (Oslo)
- EEAI, an effector for phosphatidylinositol 3-phosphate and the GTPase rab5 in endocytic membrane fusion
- 10.20 Poster Session
- 11.00 S. Ponnambalam (Dundee)
- Lipid kinases and trans-Golgi network membrane dynamics
- 11.40 S. Dove (Birmingham)
- Phosphatidylinositol 3,5-bisphopsphate: the biosynthesis and function of a "new" PtdInsP2 isomer
- 12.20 Lunch
PTDINSP2 isomer
- Chair:
- R. Irvine (Cambridge, UK)
Speakers:
- 13.30 J. Tavare (Bristol)
- Regulation of vesicle and protein trafficking by insulin in living cells
- 14.10 G. Gould (Glasgow)
- The role of phospholipid-derived signals in the control of membrane trafficking in insulin-sensitive cells
- 14.50 P. J. Cullen (Bristol)
- PI 3-kinase effector molecules
- 15.30 P. Hawkins (Cambridge)
- Searching for novel targets of PtdIns(3,4,5)P3 and PI(3,4)P2
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