Stress, Signalling and Control

University of Essex, UK

2 - 4 July 2003

Poster abstract submission is now closed.

Pfizer Research Colloquium: Molecular Mechanisms of Signalling
4 July 2003

Annual Symposium - Free Radicals: Enzymology Signalling and Disease
2 - 4 July 2003

POSTER SESSIONS

Abstracts first published on the Internet 23 June 2003

Free Radicals: Enzymology, Signalling and Disease
Annual Symposium

Wednesday 2 July 12:20 - 14:00 - Posters A1 - A10, A43 - A44

Thursday 3 July 17:30 - 19:00 - Posters A11 - A30, A40 - A42

Friday 4 July 12:50 - 14:15 - Posters A31 - A39

A1 Iron chelators reduce ferryl myoglobin and inhibit cytotoxic haem-to-protein cross-linking

Brandon J. Reeder, Robert Hider and Michael T. Wilson

A2 Poster withdrawn

A3 Characterization of the peroxynitrite-generating capacity of xanthine oxidase

Timothy M. Millar

A4 Rates of intrinsic ligand binding in Met80 mutants of ferrocytochrome c as a probe for flexibility of the distal haem pocket

Gary Silkstone and Michael T. Wilson

A5 Biphasicity in the reaction of human haemoglobin with hydrogen peroxide: a stopped-flow study

Mieebi M. Wankasi and Michael T. Wilson

A6 NADH oxidation and superoxide production by goats' milk xanthine oxidoreductase

Djebbar AtmanI and Mustapha Benboubetra

A7 Eccentric exercise induces oxidative modification of haemoglobin

Richard. J. Levermore, Amanda J. Irwin and Chris E. Cooper

A8 Prostaglandin H synthase-2 catalytically consumes nitric oxide in monocytic cells

Stephen R. Clark, Charlotte Keigwin, Marcus J. Coffey, Andrew R. Roberts, Lawrence J. Marnett and Valerie B. O'Donnell

A9 The cellular effects of myeloperoxidase-derived chlorinated products

C.M. Spickett, G. Dever, C. Paredes Oliveira and L.-J. Stewart

A10 Activation of cytochrome c to a peroxidase compound I-type intermediate by H2O2: relevance to redox signalling in apoptosis

Mark Burkitt, Clare Jones, Andrew Lawrence, Peter Wardman

A11 The erythrocyte cytoskeleton and Ca2+-induced hyper polarization in diabetes and alcoholism

V.D. Prokopieva, I.V. Petrova, A.V. Sitozhevskii, S.V. Kremeno, O.V. Tyulina and P. Johnson

A12 Protein modification in human erythrocytes in the presence of ethanol and acetaldehyde

O.V. Tyulina, V.D. Prokopieva, E.V. Denisova and P. Johnson

A13 Nitric oxide level and antioxidant defence in patients with gastric cancer

Y. Dinçer, T. Akçay, O.B. Tortum, Z. Alademir and G. Dogusoy

A14 Probing the role of mitochondria in tumour necrosis factor signalling using mitochondrially targeted reagents

E.C. Ledgerwood, G. Hughes and M.P. Murphy

A15 Targeted effects of irradiation on an in vitro blood-brain-barrier model

V.C. Stewart, R.D. Hurst, M. Folkard, B.D. Michael and K.M. Prise

A16 Splice variants of glutathione synthetase in Drosophila melanogaster

Emma J. Shanks, Muhammad Y. Gwarzo, Robert D.C. Saunders, Lesley I. McLellan

A17 Effect of the molecular chaperone groESL on iron and manganese superoxide dismutase from Escherichia coli

Thérčse Hunter and Gary J. Hunter

A18 The effect of HDL on lipid levels in THP-1 macrophages exposed to chylomicron remnants

Elizabeth H. Moore, Michael A. Avella, Keith E. Suckling and Kathleen M. Botham

A19 The effect of haemin on the mitochondrial respiratory chain in rat astrocytes

A.J. Heslegrave, V.C. Stewart, M.A. Sharpe and J.B. Clark

A20 Mitochondrial thiol redox changes during apoptosis

Nikola Costa and Michael P. Murphy

A21 Reactive oxygen species production and mitochondrial thiol redox changes during apoptosis

Christina C. Dahm and Michael P. Murphy

A22 Effect of addition of l-ascorbic acid megadoses to the diet on the antioxidative/oxidative state in rats

Niemiec Tomasz and Sawosz Ewa

A23 In vivo distribution and mobility of a truncated PARP-1-GFP fusion protein in rat fibroblast cells

N. Syrett, I.E.G. Morrison, R.J. Cherry and M.K. O'Farrell

A24 The origin of the nitration and chlorination of proteins in atherosclerotic plaques

T. Harrison, S.Y. Low, D. Baker and K.R. Bruckdorfer

A25 Revisiting the TBARS assay: protein bound plasma levels of malondialdehyde are overestimated

Niels B.J. Vollaard, Jeremy P. Shearman and Chris E. Cooper

A26 Activity of NAD(P)H oxidases in vascular fibroblasts of the normotensive and hypertensive rat

Vejra?zka Martin, Orlick´y Michal and Stípek Stanislav

A27 Characterization and regulation of the human sodium-dependent vitamin C transporter isoforms (hSVCT1 and hSVCT2) in mammalian cells by hypoxia

S. Rosier, W.-J. Liang and S.M. Jarvis

A28 Modulation of vascular dysfunction in sepsis by S-nitrosohaemoglobin

Jack H. Crawford and Rakesh P. Patel

A29 Nitric oxide and reactive oxygen species interactions in cell death

Guy C. Brown, Anna Bal-Price, Palwinder Mander and Vilmante Borutaite

A30 Proteomics analysis of cellular responses in Drosophila melanogaster to oxidative Stress

J. Mathers, R.A. Akhtar, J. Bone, R.D.C. Saunders and L.I. McLellan

A31 Nitric oxide in the mouse preimplantation embryo

R.C. Manser, H.J. Leese and F.D. Houghton

A32 Glutamate loading protects isolated cardiomyocytes against oxidative stress by stimulating glutathione peroxidase

N. King, A.P. Halestrap, J.D. McGivan and M.-S. Suleiman

A33 Lipoxygenase activity during developmental growth of green banana tissue (Musa sp.)

Lydia Williams and Mark Williams

A34 The control of mitochondrial respiration by nitric oxide is altered by chronic ethanol consumption

Sruti Shiva, Aparna Venkatraman, Shannon Bailey and Victor Darley-Usmar

A35 Regulation and targets of protein S-thiolation in the yeast Saccharomyces cerevisiae

Daniel Shenton and Chris M. Grant

A36 Nitric oxide, peroxynitrite and antioxidants as regulators of collagen biosynthesis in skin fibroblasts

Edward Truelove, Audrey Dooley, Sylvia Low, David Abraham and Richard Bruckdorfer

A37 Auto-regulation of glutathione biosynthesis in Saccharomyces cerevisiae in response to glutathione concentration

Glen L. Wheeler and Chris M. Grant

A38 The role of intermolecular disulphide linkages in regulating Drosophila melanogaster glutamate cysteine ligase activity

Jennifer A. Fraser, Robert D.C. Saunders and Lesley I. McLellan

A39 Regulating 15-lipoxygenase oxidation of membrane-bound arachidonate by protein kinase C in human monocytes

Alexandra Bermudez-Fajardo, Barbara Coles, Marcus Coffey and Valerie B. O'Donnell

A40 Poster withdrawn

A41 Poster withdrawn

A42 Free radicals in cardiopulmonary bypass (CPB): is there a role in the systemic inflammatory reaction?

M.M. Elahi, B. Ajay, B.M. Matata and M. Galińanes

A43 Inhibition of inorganic pyrophosphatase as an alternative NO-independent mechanism of aminonaphthalenesulphonamide (ANSA) toxicity

O.A. Pavlova, N.V. Beda and A.A. Nedospasov

A44 Free radical oxalate-degrading enzymes

S. Bornemann, L. Bowater, M.R. Escutia, D.M. Lawson, C.E.M. Stevenson, A. Tanner and V. Winter

Protein Synthesis and Quality Control at the Endoplasmic Reticulum

Thursday 3 July 17:30 - 19:00 - Posters B1 - B5

Friday 4 July 12:50 - 14:15 - Posters B6 - B15

B1 Towards an understanding of the role of the sigma-1 receptor in cancer

E.S. Poon, S. Hobbs, W. Court, S.A. Eccles

B2 Reconstituting amyloid precursor protein (APP) processing in vitro and in vivo

C. Duggan and S. High

B3 The biosynthesis of a polytopic membrane protein at the endoplasmic reticulum

N. Ismail and S. High

B4 Notch protein as a model substrate for intramembrane proteolysis

Jonathan E. Barks and Stephen High

B5 Interactions of Hsp70 ER lumenal chaperones

Donna Fullerton and Colin Stirling

B6 Identification of a Dlhs1 Dire1 suppressor

Lorraine Smith and Colin Stirling

B7 Dissecting the roles of Sec63p in protein translocation

A. Jermy

B8 The transient association of ribophorin I with amyloid precursor protein

Cornelia M. Wilson, Claudine Kraft and Stephen High

B9 Topology of human Na+-dependent vitamin C transporters

Albertina M. Velho, Martin J. Carden and Simon M. Jarvis

B10 Effect of oxidoreductases on intracellular folding of tissue-type plasminogen activator

Seema Chakravarthi and Neil J. Bulleid

B11 The role of ERO1 in disulphide bond catalysis

R. Watkins, C.A. Hoare, N.J. Bulleid

B12 Characterizing the endoplasmic reticulum oxidoreductins in Arabidopsis thaliana

D. Dixon, M. van Lith, R. Edwards and A. Benham

B13 Membrane protein integration at the ER: a search for novel chaperones

F.J.L. Lecomte and S. High

B14 Targeting and insertion of tail-anchored proteins to the ER

B.M. Abell

B15 Collagen assembly in C. elegans: interactions between obligate partners.

Dr. Brett Roberts and Dr. Iain L. Johnstone

Integration of Mitogenic and Migratory Signals from G-Protein-Coupled Receptors and Tyrosine Kinases

Wednesday 2 July 12:20 - 14:00 - Posters C7 - C9

Thursday 3 July 17:30 - 19:00 - Posters C1 - C5

C1 Protease activated receptors on airway epithelial cells influence tight junction recovery following disruption

J.R. Purkiss and A.F. Walls

C2 Stress-induced ATP release and growth modulation of human lens and retinal pigment epithelial cells

J.A. Eldred, J. Sanderson, I.M. Wormstone, J.R. Reddan and G. Duncan

C3 Signalling pathway involved in LPA-dependent cell migration

Tania Maffucci and Marco Falasca

C4 Bivalent b2-adrenergic ligands

G.A Jones, N. Nikbin, N.J. Kidley, C. Edwards and C.A. Reynolds

C5 Active and inactive conformations of the b2-adrenergic receptor

M.K. Dean, N.J. Kidley, P.R. Gouldson, R.P. Bywater, M.K. Dean, N.J. Kidley, P.R. Gouldson and R.P. Bywater

C6 Poster withdrawn

C7 A sequence approach to predicting protein interfaces

M.J. Frusher, M.K. Dean, R.E. Smith and C.A. Reynolds

C8 On the role of transmembrane helix 4 in G-protein-coupled receptors

H.S.X. Clark, N.J. Kidley, R.E. Smith, G.J.G. Upton and C.A. Reynolds

C9 Assessing models of the b2-adrenergic receptor as targets for virtual screening

G. Psaroudakis, H.D. Brooks, N.J. Kidley and C.A. Reynolds

Superoxide: Production and Destruction

Wednesday 2 July 12:20 - 14:00 - Posters D1 - D8

Thursday 3 July 17:30 - 19:00 - Posters D9 - D17

D1 The role of uncoupling protein-2 in pancreatic beta-cells

Katherine Green, Michael P. Murphy and Martin D. Brand

D2 Reduction of one-electron acceptors by cellobiose oxidoreductase

Maria G. Mason, Michael T. Wilson and Peter Nicholls

D3 Ubiquinone is not required for UCP1 function in mitochondria

Telma C. Esteves, Karim S. Echtay and Martin D. Brand

D4 Kinetics of superoxide scavenging by glutathione: an evaluation of its role in the removal of mitochondrial superoxide

Clare M. Jones, Andrew Lawrence, Peter Wardman and Mark J. Burkitt

D5 Novel SOD and catalase mimics for the treatment of inflammatory diseases

A.E.O. Fisher, S.C. Maxwell and D.P. Naughton

D6 Control of superoxide production in cauliflower mitochondria

V. Popov, A.M. Wagner and K. Krab

D7 Requirement for 12/15-LOX in angiotensin II-induced hypertension in vivo

Peter B. Anning, Marcus J. Coffey, Stephen R. Clark, Barbara Coles, Hartmut Kuhn and Valerie B. O'Donnell

D8 Mitochondrial DNA versus nuclear DNA: a comparative analysis of oxidative stress-induced genomic injury and repair in various cell-types

S.G. Jarrett and M.E. Boulton

D9 Anti-apoptotic Bcl-2 protein may protect CV1-P cells from 6-OHDA-induced toxicity

Sárka Manáková, Katja A. Puttonen and Pekka T. Männistö

D10 Cytochrome oxidase dysfunction: alteration of enzyme assembly and inhibition by NO

S. Horan and B. Meunier

D11 Yeast as a model for investigating mitochondrial oxidative damage

Helena M. Cochemé and Michael P. Murphy

D12 Inhibition of UCP3 causes mitochondrial oxidative damage

D.A. Talbot, K.S. Echtay and M.D. Brand

D13 Mitochondrial matrix ROS production is very sensitive to mild uncoupling

Satomi Miwa and Martin D. Brand

D14 Roles of peroxide and superoxide in the aerobic redox cycles of Sclerotium rolfsii cellobiose dehydrogenase

P. Nicholls, M. Zamocky and D. Haltrich

D15 Hypoxia simultaneously induces the expression of gp91phox and endothelial nitric oxide synthase which promotes peroxynitrite formation in the pulmonary artery

S. Muzaffar, N. Shukla, G.D. Angelini and J.Y. Jeremy

D16 Effects of reduced oxidative tension on T cell biology as a function of in vitro age

O. Duggan, K. Annett, P. Hyland and Y. Barnett

D17 Poster withdrawn

The Glucose/Fatty Acid Cycle 1963-2003: A Tribute to Sir Philip Randle

Wednesday 2 July 12:20 - 14:00 - Posters E1 - E8

E1 Identification of adipocyte glyceroneogenesis as a major target for the hypolipidaemic action of thiazolidinediones

B. Antoine, J. Tordjman, G. Chauvet, J. Quette, E.G. Beale and C. Forest

E2 SCHAD deficiency associated with hyperinsulinism: a novel glucose-fatty acid cycle?

S. Eaton, I. Chatziandreou, S. Krywawych, S. Pen, P.T. Clayton and K. Hussain

E3 Mechanism of glucose sensing in the small intestine

Jane Dyer, Steven Vayro and Soraya P. Shirazi-Beechey

E4 Post-transcriptional regulation of the ovine intestinal Na+/glucose co-transporter (SGLT1) in response to lumenal glucose

Jane Dyer, Andrew W. Moran, Irit Stern and Soraya P. Shirazi-Beechey

E5 AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2

J.A. Morrell, R.J. Butlin, U. Chauhan, R. Davies, R.M. Mayers, J.P. Orme, D. Roberts, T.E. Roche, L. Sanchez and E. Kilgour

E6 AZD7545, a novel inhibitor of PDHK2, activates PDH in vivo and improves blood glucose control in obese (fa/fa) Zucker rats

R.M. Mayers, R.J. Butlin, E. Kilgour, D.A. Martin, J. Myatt, J.P. Orme and B.R. Holloway 54

E7 The in vitro characterization of a novel glucokinase activator

Debra Carroll, Heather Wightman, Helen Vertigan, Craig Johnstone, Brendan Leighton, Matthew Coghlan and Katy Brocklehurst 54

E8 A physiology-based model of NEFA homeostasis

K.Jelic and M. Colding-Jřrgensen 55

E9 Poster withdrawn 55

Exercise Metabolism: Nutrition, Substrate Utilization and Regulation

Friday 4 July 12:50 - 14:15 - Posters F1 - F5

F1 Dietary modulation of inflammation: interactions between isoflavones and physical forces

A.N. Mundhekar, R. Chandler, H. Pruitt, B. Chacko, D. Kucik and R.P. Patel

F2 Exercise tolerance in glycogenolysis type-I

H. Mundy, P. Georgiadou, R. Wensel, A. Cousins and P. Lee

F3 Regulation of pyruvate dehydrogenase flux and activity in primary cultures of rat myotubes

Niels Grunnet, Lis Frandsen and Bjřrn Quistorff

F4 The effect of exercise on glucose and fatty acid metabolism in sedentary male subjects

F. Shojaee-Moradie, K. Baynes, C. Pentecost, J. Bell, L. Thomas, N.C. Jackson, M. Stolinski, R.H. Jones and A. M. Umpleby

F5 AMP-stimulated uncoupling of mitochondria from Drosophila melanogaster mutants expressing different amounts of the adenine nucleotide translocase

Emma J. Cornwall and Martin D. Brand

The Enzymatic Defence against Glycation in Health, Disease and Therapeutics

Wednesday 2 July 12:20 - 14:00 - Posters G1 - G7

Thursday 3 July 17:30 - 19:00 - Posters G8 - G14

Friday 4 July 12:50 - 14:15 - Posters G15 - G23

G1 Physiological function of RAGE?

Angelika Bierhaus, Bernd Arnold and Peter P. Nawroth

G2 Peptide mapping of human serum albumin modified minimally by methylglyoxal

Naila Ahmed, Yanwen Hou and Paul J. Thornalley

G3 Increased formation of methylglyoxal and protein glycation, oxidation and nitrosation in triosephosphate isomerase deficiency

Naila Ahmed, Sinan Battah, Nikolaos Karachalias, Roya Babaei-Jadidi, Margit Horányi, Klára Baróti, Susan Hollan and Paul J. Thornalley

G4 Argpyrimidine-modified Hsp27 is predominantly present in human lung squamous cell carcinomas as opposed to adenocarcinomas

Jeroen W.J. van Heijst, Hans W.M. Niessen, Klaas Hoekman, Rene J. Musters, K. Uchida and Casper G. Schalkwijk

G5 Tissue protein modification by advanced Maillard adducts can be modulated by dietary polyunsaturated fatty acids

M. Portero-Otin, M.J. Bellmunt, J.R. Requena and R. Pamplona

G6 Dimethyl sulphoxide protects endothelial cells against advanced glycation endproduct-mediated toxicity

M.S. Ahmad, Y. Duraisamy, M. Slevin, J. Gaffney, C.A. Smith and N. Ahmed

G7 Borderline thiamine deficiency induces aberrant crypt foci (ACF) in the colons of rats on a sucrose-based diet

W. Robert Bruce, Rudolf Furrer, Nandita Shangari, Peter J. O'Brien, Alan Medline and Yanping Wang

G8 Identification of heat-shock protein 27 (Hsp27) as a major methylglyoxal-modified protein in endothelial cells

Casper G. Schalkwijk, Meriem Bourajjaj, Jan van Bezu, Roel Schors, Coen D.A. Stehouwer, K. Uchida and Victor van Hinsbergh

G9 The role of glyoxalase-1 inhibition on endothelial cell activation

Meriem Bourajjaj, Jan van Bezu, Coen D.A. Stehouwer, Victor van Hinsbergh and Casper G. Schalkwijk

G10 Effect of non-enzymatic glycation on aluminium-induced lipid peroxidation of HDL

G. Ferretti, T. Bacchetti, C. Marchionni and N. Dousset

G11 Low GDP fluid has beneficial effects in peritoneal dialysis patients

P. Rutherford, A. Williams and A. Wieslander

G12 Relationship between genetic polymorphism of antioxidant enzyme diabetic complications

Kate?rina Ka?nková, Ivana Márová and Andrea Stejskalová

G13 Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats

Nikolaos Karachalias, Roya Babaei-Jadidi, Naila Ahmed and Paul J. Thornalley

G14 High concentrations of advanced glycation end products in cellular protein

Adam Lucas, Nikolaos Karachalias, Naila Ahmed and Paul J. Thornalley

G15 Removal of advanced glycation end products in clinical renal failure by peritoneal dialysis and haemodialysis

Stamatina Agalou, Naila Ahmed and Paul J. Thornalley

G16 Short-term high glucose exposure induces pentosidine formation in retinal microvascular endothelial cells

N. Frizzell, S.J. Hughes, S.R. Thorpe and A.W. Stitt

G17 Mechanism of glyoxal cytotoxicity under conditions of high glucose-induced oxidative stress

Nandita Shangari and Peter J. O'Brien

G18 Proteomic analysis of Nv-(carboxymethyl)arginine formation in ribonuclease-glyoxal model systems

William E. Cotham, Davinia J.S. Hinton, Thomas O. Metz, Jonathan W.C. Brock, Suzanne R. Thorpe, John W. Baynes, and Jennifer M. Ames

G19 Hesperetin inhibits pentosidine formation in collagen incubated with glucose in vitro. In vivo, as long-term treatment, it lowers urinary albumin clearance in diabetic rats

Paul Urios, Issam Kassab, Anne-Marie Borsos, Caroline Girard, Jacques Peyroux and Michel Sternberg

G20 Modulation of AGE-induced genomic damage in kidney tubule cells

N. Schupp, H. Stopper, M. Scheurich, R. Schinzel, K. Sebekova and A. Heidland

G21 GA-pyridine, a major antigenic structure derived from glycolaldehyde-modified proteins, accumulates in human atherosclerotic lesions

Ryoji Nagai, Yuka Unno, Xia Ling and Seikoh Horiuchi

G22 Poster abstract withdrawn

G23 High levels of free advanced glycation end products in synovial fluid in arthritis

Ifeanyi K. Amajuoyi

Molecular Mechanisms of Signalling - Pfizer Research Colloquium

Friday 4 July 12:50 - 14:15 - Posters H1 - H21

H1 Age-related vasomotor dysfunction may be due to altered Akt status in the endothelium

Anthony Smith and Tory M. Hagen

H2 Nuclear vitamin D receptor/Tcf-4/osteopontin signal transduction

Mella McCann, M. El-Tanani, M. Hoper, G. Posner and F.C. Campbell

H3 Role of protein kinase C isoforms in LPS-induced cytokine secretion by human monocytic cells

C.A. Charalambos, S.A. Rushworth and M.A. O'Connell

H4 MnSOD overexpression-induced senescence is independent of Nox1 activity

Lars Behrend, Gary Henderson and Ralf Zwacka

H5 The role of MAP kinases in lipoprotein-induced foam cell formation

L. Parish, E. Moore, M. Avella, K.M. Botham and N.T. Goode

H6 Reactive oxygen species mediate intracellular cholesterol accumulation via modulating caveolin-1 expression in Chinese hamster ovary cells

Jiangang Shen, Cindy W.S. Lee and Peter C.W. Fung

H7 Vascular cell expression of the vitamin C transporters, SVCT1 and SVCT2

R.M. Ogborne, S.A. Rushworth and M.A. O'Connell

H8 The distribution of the exogenic n-palmitamide in the mammalian tissues

M.V. Artamonov, O.D. Zhukov and N.M. Gula

H9 Synergistic interaction of arachidonic acid and 5-hydroxytryptamine in human platelet aggregation is mediated through multiple signalling pathways

A.H. Gilani, H. Rasheed and S.A. Saeed

H10 Effect of saturated N-acylethanolamine on corticosteroid level in irradiated animals

N.M. Gula, L. Storozhuk, M. Artamonov, O. Zhukov, A.A. Chumak and O.S. Mikosha

H11 Stimulation of a glycosylphosphatidylinositol-specific phospholipase in lipid raft domains mediates insulin-mimetic signaling in rat adipocytes by triggering the redistribution of lipid raft components

Günter Müller, Anna Crecelius, Susanne Wied and Wendelin Frick

H12 Activation of platelet 12-lipoxygenase via the collagen receptor glycoprotein VI and inhibition by PECAM-1

M.J. Coffey, G.E. Jarvis, J.M. Gibbins, B. Coles, N. Barrett, O.R.E. Wylie and V.B. O'Donnell

H13 Increase in ROS production following UV irradiation accelerates aging via PKC signalling in a fibroblast model

O. Bussi, M. Bergman M. Gartsbein, Z. Madar, S. Grossman and T. Tennenbaum

H14 Colocalization of cell surface receptors at high spatial resolution by single particle fluorescence imaging

Ioannis Karakikes, Rosamund E. Barber, Ian E.G. Morrison, Nelson Fernandez and Richard J. Cherry

H15 Sprouty-attenuator in RTK signalling pathway

Xuan Li, Helen Burns and J.K. Heath

H16 Ibuprofen and Alzheimer's disease: membrane-linked enzyme activation and inhibition of ab42-amyloidogenic peptide formation by ibuprofen

J. Martyn Bailey and Jack Y. Vanderhoek

H17 Paracrine and autocrine actions of sPLA2

Amandine Jaulmes, Valérie Antonio, Brigitte Janvier, Marise Andreani and Michel Raymondjean

H18 A functional polymorphic variant of DDAH2 in a basal promoter element

C. Tran, L. Jones, J. Leiper and P. Vallance

H19 Rapid S-nitrosothiol metabolism by platelets and megakaryocytes

C.M. Shah, I.C. Locke, H.S. Chowdrey and M.P. Gordge

H20 Co-ordinated regulation of the tumour suppressor gene p16 by b-catenin-Lef-1 and Ets transcription factors

C. Murphy, M. El-Tanani, M. Hoper and F.C. Campbell

H21 Regulation of MAP kinase phosphatase-2 (MKP-2) gene expression occurs via the protein kinase C (PKC) and extracellular-signal regulated kinase (ERK) dependent signalling cascades in hypertrophic cardiomyocytes

J. Kodituwakku and S. Fuller

Miscellaneous

Thursday 3 July 17:30 - 19:00 - Posters I1 - I2

I1 Comparison of effect of De-Odorase on dry matter degradation of straw, hay and concentrates in ovine ruminal fluid in vivo

J.P. Ryan, J. Mullally, T. Quinn and B.F. Leek

I2 Helix packing in membrane proteins

Matthew P. Campbell and Christopher A. Reynolds

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