Matrix turnover – mechanisms and common denominators: a Joint British Society for Matrix Biology/Biochemical Society Focused Meeting

Sheffield Hallam University, UK

2 - 3 April 2007

POSTER ABSTRACTS

Abstracts first published on the Internet 19 March 2007

Poster Session Times:

Monday 2 April 18:40–19:30

Tuesday 3 April 13:50–14:40

P001 Lipoprotein receptor-related protein 1 serves as binding partner to localize secreted cathepsin B to the surface of migrating HaCaT keratinocytes

S. Dannenmann, H. Büth, M. Rehders, R. Ostafe, C. Pietrzik, P. Boukamp and K. Brix

P002 The serine protease HtrA1 regulates physiological and pathological matrix mineralization

A.E. Canfield, K.D. Hadfield, C.F. Rock, E.C. Wylie and F.L. Wilkinson

P003 UGDH is a positive modulator of GAG production and chondrogenesis

C.E. Clarkin, S. Allen, B.T. Wheeler, C.P.D. Wheeler-Jones and A.A. Pitsillides

P004 IL1-mediated loss of aggrecan from articular cartilage is MMP17 dependent

K. Clements, J. Flannelly, J. Tart, S. Brockbank, J. Wardale, J. Freeth, A. Parker and P. Newham

P005 Investigation of the remodelling response of human tenocytes to anabolic and catabolic factors when cultured in 3D collagen gels

A.N. Corps, V.A. Curry, R.L. Harrall, B.L. Hazleman and G.P. Riley

P006 Identifiying the molecular basis of arthritis

T. Coughlan, A. Crawford, P. Hatton and M. Barker

P007 FGFR3, osteoarthritis and hypertrophic differentiation

E.A. Crawford, K.E. Silverthorne, R.J. Wardale, G.A. Wallis and R.P. Boot-Handford

P008 The molecular basis of inter-a-inhibitor heavy chain transfer on to hyaluronan

W. Tongsoongnoen, M.S. Rugg, A.C. Willis, E. Fries, C.M. Milner and A.J. Day

P009 Expression and functional characterization of the G1 domain from human versican.

H.L. Fielder, N.T. Seyfried, M. Noble and A.J. Day

P010 Collagen turnover analysis in human gingival fibroblasts treated with different doses of FK506

N. Gagliano, C. Moscheni, S. Selleri, C. Torri, G. Tartaglia, F. Costa and M. Gioia

P011 Relationship between cerebral palsy induced spasticity and tendon collagen turnover

N. Gagliano, F. Pelillo, O. Picciolini, F. Grizzi, M. Gioia and N. Portinaro

P012 Hyaluronan turnover in synovial joints

K.R. Ingram, A. Wann and J.R. Levick

P013 Ullrich congenital muscular dystrophy fibroblasts and their adhesion to extracellular matrix proteins

C. Jimenez-Mallebrera, J. Kim, S. Brown, L. Feng and F. Muntoni

P014 Evidence for increased elastin turnover in achilles tendon pathology

G.C. Jones, N. Avery, A.N. Corps, B.L. Hazleman and G.P. Riley

P015 Pharmacological regulation of adult stem cells: chondrogenesis can be induced using a synthetic inhibitor of the retinoic acid receptor

W. Kafienah, S. Mistry, M.J. Perry, G. Politopoulou and A.P. Hollander

P016 Influence of the extracellular matrix on the mechanical properties of tissue engineered cartilage

M. Plainfosse, P.V. Hatton, A. Crawford, J. Katta, Z. Jin and J. Fisher

P017 Gene targeting collagen XXVII

D.A. Plumb, M.D. Briggs, D.J. Thornton, K.E. Kadler and R.P. Boot-Handford

P018 MMP-9 activity in myoblasts and fibroblasts is interactively influenced by mechanical load and substrate

P.P. Purslow and M.C. Cha

P019 Furin regulates hypoxic inhibition of MMP-2 activation in human cardiac fibroblasts

K. Riches, M.E. Morley, C. Peers and K.E. Porter

P020 Fabricating a heparin gradient

D.E. Robinson, A. Marson, A.J. Day, D.J. Buttle and R.D. Short

P021 Teleost bone and cartilage ECM proteins

F.A. Vieira and D.M. Power

P022 Graded coupling of hyaluronan secretion to joint movement; role of transcription/translation.

A.K.T. Wann, K. Ingram and J.R. Levick

P023 A novel role for COX-2 regulating HA synthesis and binding in developing joints

B.T. Wheeler, C.E. Clarkin, C.P.D. Wheeler-Jones and A.A. Pitsillides

P024 Mechanical environment of cartilage cells

M. Adams

P025 The influence of nutrient supply on the growth of intervertebral disc cells

E. Johnson, S. Stephan and S. Roberts

P026 Immunolocalisation of matrix proteins in the intervertebral disc and endplate in scoliosis

P.N. Jones, J. Menage, S.M. Eisenstein, W.E.B. Johnson and S. Roberts

P027 Age-related changes of cytoskeletal composition: a preliminary study of the role of cytoskeleton in intervertebral disc degeneration

S. Li, E.J. Blain and V.C. Duance

P028 Astrocyte–leucocyte interactions and the mechanisms regulating matrix degradation in CNS tuberculosis

J.E. Harris, R.K. Nuttall, J.A. Green, P.T. Elkington, M.B. Graeber, D.R. Edwards and J.S. Friedland

P029 Bovine brain matrix metalloproteinases; detection and inhibition

E. Ganea, M. Trifan, A.C. Laslo, G. Putina and C. Cristescu

P030 Changes in brain expression of chondroitin sulphate proteoglcans (CSPGs) following transient middle cerebral artery occlusion in the rat

G. Haddock, A.K. Cross, S. Allan, R.A.D. Bunning, D.J. Buttle and M.N. Woodroofe

P031 Fibrillin-1 regulates the bioavailability of TGFb1

S.S. Chaudhry, S.A. Cain, A. Morgan, S.L. Dallas, C.A. Shuttleworth and C.M. Kielty

P032 Biochemical evaluation of hepatocellular dysfunction and extracellular matrix alteration in mice infected with Schistosoma mansoni

F. A. Kassim and B.A. Iwalokun

P033 Tenascin-C regulates fibroblast migration within 3D fibrin–fibronectin matrices

A. Trebaul, E. Chan and K. Midwood

P034 TIMP-3 expression in prostate stromal and tumour cells is regulated by androgen and TNF

O.O. Adeniji, C.N. Molokwu, E.A. Waterman, N.A. Cross, F.C. Hamdy and D.J. Buttle

P035 Bone marrow stromal cell-derived insulinslike growth factor (IGF) II enhances growth and survival of prostate cancer cells and potentiates androgen action

N.A. Cross, M. Papageorgiou, J. Lippitt, R. Nyambo, F.C. Hamdy and C.L. Eaton

P036 Poster withdrawn

P037 Analysis of prostate tumour cell invasion using BD FluoroBlok™ insert systems and the FLUOstar OPTIMA fluorescence microplate reader

C.A. Hart, N.W. Clarke and M.D. Brown

P038 Distinct roles of the haemopexin and the transmembrane domains as dimer interfaces of MT1-MMP on the cell surface

Y. Itoh, N. Ito, Y. Otake, H. Nagase and M. Seiki

P039 Imaging proteolysis in prostate cancer and stromal cells

C.N. Molokwu, O.O. Adeniji, F.C. Hamdy and D.J. Buttle

P040 Regulation of ADAMTS expression in prostate cancer and stromal cells by androgen and TNF

C.N. Molokwu, O.O. Adeniji, F.C. Hamdy and D.J. Buttle

P041 Exploring new roles for cathepsin K in prostate cancer

I. Podgorski, B.E. Linebaugh and B.F. Sloane

P042 Breast cancer cell migration through Matrigel™: the importance of glycosidase enzymes

K. Ramessur, P. Greenwell, M.V. Dwek

P043 Phagocytosis of collagen by fibroblasts and invading cancer cells is mediated by MT1-MMP

H.R. Lee, K.L. Sodek, Q. Hwang, T.J. Brown, M. Ringuette and J. Sodek

P044 Tumour cell–bone marrow stromal cell interactions modify expression of cathepsin K, ADAMTS-15, TIMP-3 and osteoprotegerin (OPG)

J. Woodward, D. Lefley, N. Cross, P.D. Ottewell, D.J. Buttle, R.E. Coleman and I. Holen

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