Pattern-recognition receptors in human disease

Queens' College, University of Cambridge, UK

8 - 10 August 2007

POSTER ABSTRACTS

Abstracts first published on the Internet 02 August 2007

Poster Session Times:

Wednesday 8 August 17:45–19:30 (P001–P038)

Thursday 9 August 17:55–19:30 (P039–P074)

Poster Session 1, 8 August 17:45–19:30 (P001–P038)

 

P001 Role of CD14 in the recognition of smooth and rough LPS in the lung

A.A. Anas, A.F. de Vos and T. van der Poll

P002 Mapping the regions required for Toll and Spaetzle activation

C. Arnot, M. Gangloff, A. Weber and N. Gay

P003 Abstract withdrawn

P004 Investigation into a possible role for Btk in SHIP-1 regulation

K.V. Brennan and C.A. Jefferies

P005 IRAK-4 regulates transcriptional and post-transcriptional control of TLR/IL-1R responses by accessory pro-inflammatory signalling in a child with Q293X mutation

D.J. Davidson, A.J. Currie, D.M.E. Bowdish, R.C. Ma, C.M. Rosenberger and D.P. Speert

P006 Involvement of FcgRII signalling in the neutralization of LPS activity via a potent novel anti-TLR4 MAb

O. Leger, I. Dunn-Siegrist, F. Depis, B. Daubeuf, A.-C. Raby, M. Kosco-Vilbois, Y. Dean, J. Pugin and G. Elson

P007 The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and acts as an opsonin though complement activation

C. Garlanda, F. Moalli, S. Jaillon, Y. Delneste, P. Jeannin, A. Doni, L. Romani and A. Mantovani

P008 Interactions of taxoids with human MD-2

H. Gradisar, J. Vašl and R. Jerala

P009 Innate immunity is required for defence against bacterial infections in Zebrafish

D. Gupta, X. Li, S. Wang, S.F. Echtenkamp, J. Qi, R. Chatterjee and R. Dziarski

P010 TLR-4 expression in the genital tract

S. Herath, C.E. Bryant and I.M. Sheldon

P011 Structure-function analysis of caspase-1/CARD mediated NF-kB activation

K. Kersse, M. Lamkanfi, T. Vanden Berghe and P. Vandenabeele

P012 Negative regulatory activity of soluble Toll-like receptor 2: mechanism and biological relevance

A.-C. Raby, E. Le Bouder, C. Colmont, J.E. Rey-Nores, P. Richards, S.A. Jones, P. Brennan, N. Topley and M.O. Labéta

P013 Role of MyD88 in LPS induced hypoxic-ischemic brain injury in neonatal mice

X. Wang, C. Nie, K. Eriksson, H. Hagberg and C. Mallard

P014 MARCKS-lipopolysaccharide interaction in cells and its effect on LPS sequestration and signalling

M. Mancek-Keber, B. Japelj, J. Andrä, K. Brandenburg, M. Triantafilou, K. Triantafilou and R. Jerala

P015 SOCS-1 negatively regulates TLR signalling by mediating MAL degradation

A. Mansell, L.A.J. O’Neill and P.J. Hertzog

P016 Modelling TLR4 TIR receptor:adaptor interactions – a specific scaffold for adaptor recruitment

R. Núńez Miguel, J. Wong, J. Westoll, H. Brooks, L. O’Neill, N. Gay, C. Bryant and T. Monie

P017 Regulation of interaction between IRAK4 and MyD88 death domain by autophosphorylation

G. Motshwene, L. Pellegrini and N. Gay

P018 Primary murine bone marrow macrophages can be re-infected by Salmonella entericia serovar Typhimurium in vitro

A. Murcia, T.J. McKinley, O. Restif, J. Wood, D. Maskell, J. Gog and C.E. Bryant

P019 A role for TLR4 ectodomain in controlled LPS-induced signal transduction in mammalian cells

G. Panter, N. Pirher and R. Jerala

P020 Polymorphic variant D299G.T399I of TLR4 exhibits reduced activation by monomeric endotoxin:MD-2 complex

P. Prohinar, T. Gioannini and J. Weiss

P021 Abstract withdrawn

P022 The role of the adaptor molecules MyD88, MAL and TRIF during the Toll-like receptor 4-induced immune response to Salmonella infections

S. Talbot, S. Tötemeyer, M. Yamamoto, S. Akira, P. Mastroeni, D.J. Maskell and C.E. Bryant

P023 The MyD88-independent pathway is not mobilized in human neutrophils stimulated via TLR4

N. Tamassia, V. LeMoigne, M. Donini and M.A. Cassatella

P024 MD-2 G56R polymorphic variant shows reduced LPS binding and LPS-dependent activation of TLR4

J. Vašl, M. Treeby Premuš, P. Prohinar, T. Gioannini, J. Weiss and R. Jerala

P025 Identification of the regions of MD-2 and TLR4 that are required for activation of the horse receptor complex by lipid IVa

C.M. Walsh, M. Gangloff, T. Monie, T. Smyth, D. Maskell, N. Gay and C. Bryant

P026 Structural and functional characterisation of Toll-like receptor pathway single nucleotide polymorphisms

S. Merx, A. Kubarenko, M. Neumaier, A. Weber and P. Ahmad-Nejad

P027 Role of triggering receptors expressed on myeloid cells (TREM)-1 in Gram-negative sepsis (melioidosis)

W.J. Wiersinga, C. van ‘t Veer, C.W. Wieland, S. Gibot, B. Hooibrink, N.P. Day, S.J. Peacock and T. van der Poll

P028 CD14 impairs host defence in sepsis caused by Burkholderia pseudomallei

W.J. Wiersinga, A.F. de Vos, C.W. Wieland, M. Leendertse, S. Florquin and T. van der Poll

P029 Enhanced secretion of functional sMD-2 by the endothelium during inflammation; a novel component of the innate immune system?

T.G.A.M. Wolfs, I. Dunn-Siegrist, C. van ’t Veer, C.M.I.M. Hodin, W.T.V. Germeraad, M. van Zoelen, R.-J. van Suylen, C.J. Peutz-Kootstra, J. Pugin and W.A. Buurman

P030 The response of intracellular Salmonella enterica serovar Typhimurium to TLR4 modulation of the host environment

J.A. Wright, S. Tötemeyer, J.C. Hinton, I. Hautefort, A. Thompson, D.J. Maskell and C.E. Bryant

P031 MD-2 is an opsonin for Gram-negative bacteria

V. Jain, A. Halle, K.A. Halmen, D.T. Golenbock and A. Visintin

P032 Role of prostacyclin IP receptors in the sensing of Gram negative bacteria

L. Moreno, L. Bailey, L. Harrington, S.K. McMaster, M. Paul-Clark, S. Sriskandan and J.A. Mitchell

P033 Toll-like receptor 2 is essential for the sensing of oxidants during inflammation

M.J. Paul-Clark, S.K. McMaster, R. Sorrentino and J.A. Mitchell

P034 Inhibitory function of PPARb in the sensing of the TLR4 ligands E. coli and LPS by macrophages

L.K. Bailey, L. Moreno, S.K. McMaster, M. Paul-Clark, S. Sriskandan and J.A. Mitchell

P035 Constitutive and UV-B induced expression of Nod-like receptors and their functional partners in human corneal epithelial cells

S. Benko, J. Tozser, G. Miklossy, J. Kadas, A. Csutak, A. Berta and E. Rajnavolgyi

P036 TLR-independent Type I interferon induction in response to an extracellular bacteria is based on an intracellular receptor

M. Charrel-Dennis, M. Severa, N. Goutagny, K.A. Fitzgerald, D.L. Kasper and D.G. Golenbock

P037 Lack of Toll like receptor 4 is linked to a loss in endothelium function in mesenteric arteries

L.S. Harrington, E. Belcher, L. Moreno, M.J. Carrier and J.A. Mitchell

P038 Inhibition of TLRs in rheumatoid arthritis (RA) reduces inflammation in the murine CIA model and inflammatory cytokines in the human RA model

S. Sacre, A. Lo, M. Medghalchi, B. Gregory, L. Williams, F. Brennan, R. Williams and B. Foxwell

Poster Session 2, 9 August 17:55–19:30 (P039–P074)

 

P039 Conserved and distinct features of the avian TLR system and implications for control of bird-borne zoonoses

A. Boyd, V. Philbin, M. Iqbal and A. Smith

P040 SARM is a negative regulator of TRIF dependent TLR signalling

M. Carty, R. Goodbody, M. Schröder, J. Stack, P.N. Moynagh and A.G. Bowie

P041 The Type I interferon and cytokine response of plasmacytoid and myeloid dendritic cells in response to resiquimod

N. Charlaftis, P. Morley, D. Fearon and A. Schoenemeyer

P042 Purification, crystallization and functional characterization of retinoic acid inducible gene-I

J.-H.J. Choo, M. Moncrieffe, A. Schoenemeyer, P. Morley and N. Gay

P043 Profiling antiviral response pathways following TLR stimulation of human blood

D. Hamilton, T. Parkinson, H. Perkins, P. Brain, M. Lewis and C. Laxton

P044 Diverse approaches to high-throughput screening of pattern recognition receptors

G. Williams, F. Bertelli, C. Chambers, R. Corbau, R. Grimley, N. Horscroft, T. Stroud, A. Thornberry and L. Willis

P045 Involvement of TRAF2, 3 and 6 in herpes simplex virus (HSV) activated signal transduction and cytokine expression in macrophages

S.B. Jensen and S.R. Paludan

P046 Identification of the TLR3 signalling complex

J.N. Leonard, J. Askins, Y. Wang, R. Ghirlando, J. Shiloach, J. Bell, D. Margulies, D. Davies and D.M. Segal

P047 Diversity of human immune responses in blood to IFNa and a TLR7 agonist

H. Perkins, C. Laxton, T. Parkinson, D. Hamilton, N. Horscroft, D. Collins and F. Sanders

P048 IFN-a regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages

J. Pirhonen, J. Sirén, I. Julkunen and S. Matikainen

P049 TLR9 and RIG-I co-ordinately induce cytokine expression during herpes simplex virus type 2 infection in macrophages

S.B. Rasmussen, S.B. Jensen and S.R. Paludan

P050 The vaccinia virus protein K7 modulates innate immune signalling pathways

M. Schröder, S. Lucas, O. Mulhern, G.L. Smith and A.G. Bowie

P051 Activation of NF-kB: a novel approach to vaccination

J. Wales, E. Andreakos, B. Foxwell, R. Williams, G. Buchan and M. Feldmann

P052 Recognition and orientation of host cell response by PRRs as a function of glycans expressed by yeasts

A. Sarazin, M. Martínez-Esparza, D. Poulain and T. Jouault

P053 Toll-like receptor cross-hyporesponsiveness is functional in IRAK-1 deficient mice

M. Berglund, J.A. Thomas, E. Hultgren Hörnquist and O.H. Hultgren

P054 Salmonella evades early innate immune recognition by the intestinal epithelium

C.U. Duerr and M. Hornef

P055 Toll-like receptor-4 (TLR4) signaling is important for colitis-induced tumorigenesis: role of a disintegrin and metalloproteinase (ADAM)-17 and amphiregulin

M. Fukata, A. Chen, K. Breglio, T. Goo, D. Conduah, D. Hsu, K. Subbaramaiah, A.J. Dannenberg and M.T. Abreu

P056 Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the IL-1 receptor family

C. Garlanda, F. Riva, T. Veliz, N. Polentarutti, F. Pasqualini, E. Radaelli, M. Sironi, M. Nebuloni, E. Scanziani and A. Mantovani

P057 Role of TLR2 in Salmonella enterica serovar Typhimurium infection

S. Tötemeyer, P. Kaiser, T. Smyth, S. Talbot, J. Wright, D.J. Maskell and C.E. Bryant

P058 TLR3 triggering induces caspase-1 independent IL-1b maturation and secretion

E. Vercammen, S. Janssens, P. Schotte, M. Haegman, S. Magez and R. Beyaert

P059 Phosphorylation of Ro52 by Bruton’s tyrosine kinase (Btk)

E.P. Breen and C.A. Jefferies

P060 The DNA sugar backbone 2-deoxyribose determines Toll-like receptor 9 activation

T. Haas, J. Metzger, F. Schmitz, A. Heit, T. Müller, E. Latz and H. Wagner

P061 The E3 ubiquitin ligase RO52 inhibits IFN-b gene transcription by initiating proteasomal degradation of IRF3

R. Higgs, J. Ní Gahbann, N. Ben Larbi and C. Jefferies

P062 The effect of dexamethasone on the transcription factor IRF3

C. McCoy and L. O’Neill

P063 CD200-CD200R, novel inhibitory regulators of TLR function

S. Mukhopadhyay, D.M.E. Bowdish, N. Barclay and S. Gordon

P064 Regulation of autoimmune inflammatory demyelination by the innate immune system: relevance to multiple sclerosis

K. O’Brien and B. Gran

P065 TLR independent recognition of viral nucleic acids in mesangial cells

A. Ramanjaneyulu and H.-J. Anders

P066 Activation of TLR2 or TLR4 modulates the responses of intrinsic renal and immune cells in systemic lupus

R.D. Pawar and H.-J. Anders

P067 Toll-like receptor (TLR)-7 inhibition protects against sytsemic lupus

R.D. Pawar and H.-J. Anders

P068 Importance of different leucine-rich repeats within TLR9 for activation by CpG-DNA

M. Peter, K. Heeg and A.H. Dalpke

P069 Investigation of SIGIRR function in human dendritic cells

S.K. Drexler, S.M. Sacre, M. Feldmann and B.M. Foxwell

P070 The role of SIGIRR in Th2 response

K. Bulek, S. Swaidani, J. Qin, Y. Lu, F. Gulen, B. Min, R.A. Kastelein, S. Pflanz, M. Aronica, M. Kosz-Vnenchak and X. Li

P071 Using lentivirus as a tool for the study of neutrophil biology

E.P. Dick, L.R. Prince, E.C. Jones, S.A. Renshaw, M.K.B. Whyte and I. Sabroe

P072 Abstract withdrawn

P073 Deciphering the structure/function relationships of lipoglycans signaling via Toll-like receptor-2

J. Nigou, T. Vasselon, A. Ray, P. Constant, M. Gilleron, G. Tiraby and G. Puzo

P074 Hck tyrosine kinase mediates TLR4 signalling in human macrophages

M. Smolinska-Bylanska, N. Horwood, T. Page and B. Foxwell

Biochemical Society/Portland Press Third Floor Eagle House 16 Procter Street London WC1V 6NX United Kingdom Map Biochemical Society Registered Company Number 892796 limited by guarantee VAT No. GB 523 2392 69 Registered Charity Number 253894 Portland Press Ltd Registered Company Number 2453983 Vat No GB 523 2392 69 Biochemical Society Membership Office Portland Customer Services Commerce Way Whitehall Industrial Estate Colchester Essex CO2 8HP United Kingdom Map

Administration: Tel: 020 7280-4100 - Fax: 020 7280-4170 E-mail: genadmin@biochemistry.org Editorial: Tel: 020 7280-4110 - Fax: 020 7280-4169 E-mail: editorial@portlandpress.com Meetings: Tel: 020 7280-4150 - Fax: 020 7280-4167 E-mail: meetings@biochemistry.org Membership: Tel: 01206 796 351 - Fax: 01206 799 331 E-mail: Membership@Biochemistry.org Customer services: Tel: 01206 796 351 - Fax: 01206 799 331 E-mail: sales@portland-services.com Read our Privacy Policy