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6 November 2006 Poster Session 1: 18:30
P001 Role of class IA PI3K in T cell function and autoimmunity
D.A. Fruman, J.A. Deane, J.S. Oak, M.G. Kharas, J. Luo, H. Ji, C. Rommel, T.E. Lane and L. Cantley
P002 PI3K and the PH domain adaptor Bam32/DAPP1 regulate B lymphocyte antigen presentation and T cell-dependant antibody responses
M. Al-Alwan, T. Zhang, A. Allam, S. Hou, K. Okkenhaug, B. Vanhaesebroeck and A.J. Marshall
P003 P110d is required for innate immunity to allografts and tumours.
A. Saudemont, N. Kim, M. Turner, K. Okkenhaug and F. Colucci
P004 PI3K-NOS3 pathway in shock
A. Cauwels, B. Janssen, E. Buys, P. Sips and P. Brouckaert
P005 Influenza A virus NS1 protein binds p85-beta and activates PI3K/Akt signalling
B.G. Hale, D. Jackson, Y.-H. Chen, R.A. Lamb and R.E. Randall
P006 Essential role of the p110d PI3-kinase in axonal growth and regeneration of sensory neurons
B.J. Eickholt, A.I. Ahmed, M. Davies, W. Pearce, M.L. Starkey, A. Bilancio, E.J. Bradbury and B. Vanhaesebroeck
P007 Subcellular regulation allows the Drosophila PI3-kinase/Akt signalling cassette to perform different functions
D.C.I. Goberdhan, N. Vereshchagina, N. Pinal, L. Collinson, Y. Fujita, I. Cox, F. Pichaud and C. Wilson
P008 PLCg1 mediates the PI3K-dependent Akt activation in FGF-2 signalling
T. Maffucci, I. Zachary and M. Falasca
P009 PI3K inhibitors in 2006 - 15 years of discovery after LY-294002
T. Rückle, M.K. Schwarz and C. Rommel
P010 A growth factor receptor phospho-Tyr/phospho-Ser motif that acts as a binary switch to control PI3-kinase signalling is deregulated in leukemia
J.A. Powell, F.C. Stomski, H. Ramshaw, A.F. Lopez and M.A. Guthridge
P011 Design and characterisation of a small molecule inhibitor specific for PTEN
E. Rosivatz, N.Q. McDonald, E.W.-F. Lam, R. Vilar and R. Woscholski
P012 PI3K co-stimulation in immuno-reproductive failure
A.O. Dare and A. Segun
P013 Impact of selective inhibitors of the p110d isoform of PI-3kinase in the proliferation, survival and differentiation of acute leukaemia
C. Billottet, V.L. Grandage, R.E. Gale, A. Quattropani, C. Rommel, A. Khwaja and B. Vanhaesebroeck
P014 Search of possible targets of PI3K/Akt pro-apoptotic signaling in muscle-derived primary cell lines after cisplatin treatment
D. Bironaite, V. Bukelskiene, D. Baltriukiene, J. Šmigelskaite, A. Imbrasaite, A. Stulpinas and A. Kalvelyte
P015 Modelling early haemopoietic development using murine embryonic stem (ES) cells: the involvement of PI3Ks
H.K. Bone and M.J. Welham
P016 PKB/Akt activity is important for epithelial-mesenchymal transition during renal fibrosis
J.J. Kattla, C. Godson and D.P. Brazil
P017 Phosphatidylinositol-3-kinase g (PI3Kg) in mast cell adhesion
E. Clément, M. Thomas and M.P. Wymann
P018 PI3Kgamma-CAAX breaks cell polarity in chemotaxing cells
C. Costa, L. Barberis, A. Manazza, C. Ambrogio, E. Patrucco, O. Azzolino, P. Nielssen, E. Ciraolo, F. Altruda, G. Prestwich, R. Chiarle, M. Wymann, A. Ridley and E. Hirsch
P019 Development of a high throughput semi-automated assay to measure phosphoinositide 3-kinase (PI3K) enzyme activity
T. Harding, D. Jones, M. Fitzek, H. Olsson and S. Cosulich
P020 Ultrasensitive mass spectrometric quantification of the PI3K/Akt signaling pathway in absolute units
P.R. Cutillas, M.D. Waterfield and B. Vanhaesebroeck
P021 The role of the PTEN in the development of hormone refractory prostate cancer
J. Edwards, P. Traynor, T. Kirkegaard, C.J. Witton, K. Grigor, K.V. Nielsen and J.M.S. Bartlett
P022 Time-course of insulin signal transduction in vivo
G. Frangioudakis, J.-M. Ye and G.J. Cooney
P023 The PI3K p110d is required for PIP3 accumulation at the immune synapse
F. Garcon, T. Sasaki and K. Okkenhaug
P024 Quantitative analysis of class IA PI3K reveals tight regulation of subunit expression: PI3Ks are obligate heterodimers
B. Geering, P.R. Cutillas, G. Nock, S. Gharbi and B. Vanhaesebroeck
P025 Effects of phosphoinositide identity and lateral organization on PTEN binding and structure
A. Gericke, R.E. Redfern and A.H. Ross
P026 PI3Kg controls migration of SK-N-LO neuroblastoma cell line
M. Gruen, C. Koenig, V. Spitzenberg, I. Gose, S. Horn, A. Voigt and R. Wetzker
P027 Role of PI3K isoforms in platelet thrombus formation and procoagulant activity
J.M.E.M. Cosemans, P.E.J. van der Meijden, R. Wetzker, R. Heller, S.P. Jackson, I.C.A. Munnix and J.W.M. Heemskerk
P028 Phospholipid induced inhibition of the PI3Kg phosphorylating activity
A. Hermelink, C. Kirsch, R. Klinger and G. Brezesinski
P029 IGF-1 potentiates platelet aggregation via the IRS-1/PI3 kinase/PKB pathway
I. Hers
P030 Inhibition of PI3K sensitizes the tumour neovasculature to TNF
L. Huyghe, A. Goethals, J. Hostens and P. Brouckaert
P031 The epistatic relationship between PTEN and the PI3K catalytic subunit p110d in B cell development
M.L. Janas, Z. Stamataki, S. Hill, K. Welch and M. Turner
P032 Effects of serum-deprivation, PI3-kinase inhibition and cisplatin exposure on P-PKB, Puma and Bcl-XL expression in malignant mesothelioma cells
V. Janson and K. Grankvist
P033 Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations
A. Metzner, M.A. Horstmann, B. Fehse, G. Ortmeyer, C.M. Niemeyer, C. Stocking, G.W. Mayr and M. Jücker
P034 FGF-2 induced by IL-1b through the action of PI3-kinase mediates endothelial mesenchymal transformation
H.T. Lee and E. Kay
P035 Regulation of murine embryonic stem cell lineage specification by PI3K-dependent signals
E. Kingham and M. Welham
P036 Regulation of p110d PI3K gene expression
K. Kok, E. Verrall and B. Vanhaesebroeck
P037 Identification and characterization of serine 357, a new phosphorylation in insulin receptor substrate (IRS)-1
R.S. Wariach, L. Immel, M. Hoene, C. Weigert, A. Beck, W. Voelter, E.D. Schleicher, H.-U. Häring and R. Lehmann
P038 Loss of PTEN selectively desensitises IGF1 and insulin signalling
J. Lackey, J. Barnett, L. Davidson, I. Batty, N. Leslie and P. Downes
P039 Synergistic collagenase production and cartilage degradation induced by interleukin-1 and oncostatin M is dependent on PI3K activity
G.J. Litherland, C. Dixon, R.L. Lakey, D. Jones, T.E. Cawston, D.A. Young and A.D. Rowan
P040 Regulation of PI3K signaling by oxidants: hydrogen peroxide selectively enhances immunoreceptor-induced recruitment of phosphatidylinositol (3,4) bisphosphate-binding PH domain proteins in lymphocytes
S.M.S. Cheung, J.C. Kornelson, M. Al-Alwan and A.J. Marshall
P041 Role of the phosphoinositide 3-kinase p110d in regulation of type 2 cytokine responses and allergic airway inflammation
B.F. Nashed, T. Zhang, M. Al-Alwan, G. Srinivasan, A.J. Halayko, K. Okkenhaug, B. Vanhaesebroeck, K.T. HayGlass and AJ. Marshall
P042 The role of PI3K isoforms in cytokine signalling and wound healing in A549 lung epithelial cells
D.A. Medina-Tato, S.G. Ward and M.L. Watson
P043 Targeting the PI3K pathway in melanoma
R. Marone, S.-M. Maira, A. Klippel, A. Mertz, F. Stauffer, P. Furet, C. Garcia-Echeverria and M.P. Wymann
P044 Generation and characterisation of PtdIns(3,4)P2 transgenic bioprobe to explore spatio-temporal regulation of PI(3,4)P2 accumulation in T lymphocytes
R.V. Parry, L. Sinclair, D.A. Cantrell and S.G. Ward
P045 PI3K p110d plays a role in the development and function of Foxp3+ T regulatory cells
D.T. Patton, F. Ramadani, J.L. Emery, W.P. Pearce, B. Vanhaesebroeck, W.C. Rowan and K. Okkenhaug
P046 PTEN is destabilised by regulated phosphorylation of Thr-366
N. Perera, H. Maccario, N. Leslie, L. Davidson and P. Downes
P047 Design of a novel class of potent and highly isoform selective PI3Kg inhibitors
V. Pomel, J. Klicic, M. Camps, P.A. Vitte, C. Rommel, M.K. Schwarz and T. Rückle
P048 The roles of p110a and p110d in B cell development
F. Ramadani, B. Vanhaesebroeck and K. Okkenhaug
P049 Evaluation of nucleofection to deliver PI3K targeting siRNA into peripheral blood-derived T lymphocytes
L. Smith, E. Hickman, J. Westwick and S.G. Ward
P050 Analysis of the role of PI3K Isoforms in CXCR4- and CXCR3-mediated T lymphocyte chemotaxis.
L. Smith, E. Hickman, J. Westwick and S.G. Ward
P051 Transcriptomic analysis of embryonic stem cell self-renewal: identifying downstream effects of PI3K-dependent signalling
M. Storm, H. Bone, C. Beck, P.-Y. Bourillot, V. Schreiber, P. Savatier and M. Welham
P052 The selective pharmacological inhibition of PI3K isoforms and effects on insulin signalling
N. Torbett, A. Zhyvoloup, A. Robson, D. Kugendradas, N. Saghir, S. Patel, F. Leenders and A. Brown
P053 The role of the PI3K/Akt cascade in the development of hormone refractory prostate cancer.
P. Traynor, L.K. Gemmell, R. Mukherjee, T. Kirkegaard, C.J. Witton, K. Grigor, K.V. Nielsen,
S.J.S. Grimsley, M.A. Underwood, J.M.S. Bartlett and J. Edwards
P054 Effects of dexamethasone on IGF-1 signalling in insulin secreting cells
S. Ullrich, D. Avram, F. Ranta, A.-M. Hennige, H.-U. Häring and F. Lang
P055 Enhanced resistance to intracellular pathogen in PI3K- deficient mice due to defective expansion of natural regulatory T cells
D. Liu, A. Marshall, K. Okkenhaug, B. Vanhaesebroeck and J. Uzonna
P056 Activation of PI3Kg in mast cells downstream of FceRI, Ca2+-influx and PKCb
R. Walser, K. Björklöf, P. Küenzi, M. Laffargue, M. Leitges, E. Hirsch and M.P. Wymann
P057 Evidence of a PI3-K independent role for PKB/Akt in T lymphocyte chemotaxis
A. Webb, D. Cronshaw, T. Crabbe and S.G. Ward
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