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Metal metabolism: transport, development and neurodegeneration

9—10 July 2008

Imperial College London



9 July 2008

Poster Session 1: 12:00-14:00


P001 The antioxidant and metal chelating properties of MESNA
D. Mazor and N. Meyerstein
P005 COMMD1 as a novel regulator of SOD1 activity and aggregation in amyotrophic lateral sclerosis
W. Vonk, B. van de Sluis, R. Berger, C. Wijmenga and L. Klomp
P007 The role of DcytB in intestinal iron absorption
J.H. Choi, Y. Latunde-dada, A. Laftah, A.T. McKie and R.J. Simpson
P009 Three histidine residues of amyloid beta peptide control the redox activity of transition metals
M. Nakamura, N. Shishido, A. Nunomura, M.A. Smith, G. Perry and T. Hayashi
P011 Prion protein does not redox-silence Cu2+, but is a sacrificial quencher of hydroxyl radicals
R. Nadal, S.R. Abdelraheim, M.W. Brazier, S.E.J. Rigby, D.R. Brown and J. Viles
P013 Iron metabolism of Drosophila melanogaster: a magnetic approach
L. Gutiérrez, F.J. Lázaro and F. Missirlis
P017 Neuroprotective actions of a novel 2-amido-3-hydroxypyridin-4(1H)-one iron chelators against Alzheimer’s disease relevant insults
F. Molina-Holgado, A. Gaeta, P. Francis, R.J. Williams and R.C. Hider
P019 Impaired motor coordination and cortical hypomyelination in Hemopexin-null mice
N. Morello, E. Tonoli, F. Favilla, L. Silengo, A. Vercelli, F. Altruda and E. Tolosano
P021 A role for PrPC in neuronal zinc metabolism
N. Watt, D. Taylor and N. Hooper
P023 Cu (II) binding to monomeric and fibrillar Ab: coordination geometry, stoichiometry, pH dependence and affinity
C. Sarell , S. Rigby and J. Viles
P025 Influence of iron homeostasis on the expression of zinc transporter mRNA in mice duodenum: preliminary study
P. Masaratana, A.H. Laftah, G.O. Latunde-Dada, R.J. Simpson and A.T. McKie
P029 Whither aluminium
C. Exley

10 July 2008

Poster Session 2: 12:25 - 14:30


P004 Impaired iron binding and protein misfolding in clinical frataxin variants
A.R. Correia, C. Pastore, S. Adinolfi, A. Pastore and C.M. Gomes
P006 ZIP7 controls intracellular zinc distribution providing a breast cancer target
K.M. Taylor, N. Jordan, S. Hiscox and R.I. Nicholson
P008 Studies into the production of hydrogen peroxide during the aggregation of b amyloid using Amplex red
J. Mayes, S. Moore, B. Tabner and D. Allsop
P010 Deconvoluting the copper2+ binding modes of full-length prion protein
M. Klewpatinond, P. Davies, S. Bowen, D.R. Brown and J.H. Viles
P012 Alpha synuclein, metals and neurodegeneration
D. Moualla, D. Brown and J. Wright
P014 The role of metal ions in the toxicity of the amylin peptide implicated in type-2 diabetes mellitus and the protective effects of antioxidants and metal ion chelators
A. Masad, B. Tabner and D. Allsop
P018 Novel Drosophila mutants with discrepancies in iron metabolism
A. Mehta, A. Deshpande and F. Missirlis
P020 Altered cellular zinc homeostasis contributes to pathology in Niemann-Pick type C disease, a neurodegenerative lysosomal storage disorder
L. Williams, F. Platt and E. Lloyd-Evans
P022 Albumin as a zinc carrier - properties of its high-affinity zinc-binding site
J. Lu, T. Pinheiro, P.J. Sadler and C.A. Blindauer
P024 Imaging iron influx and iron-induced toxicity in neurons and astrocytes
I. Pelizzoni, R. Macco, D. Zacchetti, F. Codazzi and F. Grohovaz
P026 Hepcidin, an iron regulatory hormone, crosses the blood-brain barrier and provides a mechanistic link between the iron mishandling and inflammation that coexist in neurodegenerative diseases
J.W. Zhao, A.A. Raha, J. Marland, A. Bomford and R. Raha-Chowdhury
P028 Cu(II) and Zn(II) interaction with b-amyloid peptide fragments affect their oligomerization and toxicity
V.G. Nicoletti, C. Damante, C. Cuppari, K. Ösz, Z. Nagy, I. Sóvágó, G. Grasso, G. Pappalardo and E. Rizzarelli
P030 Zinc transport across SH-SY5Y plasma membranes
N. Beyer, D.T.R. Coulson, R. Cherny, I. Volitakis, A.I. Bush, G.B. Irvine and J.A. Johnston