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3 December 2007 Poster Session 1: 17:00-18:30
P001 De-differentiation facilitates hepato-pancreatic transdifferentiation
S. Thowfeequ, W.-C. Li, K.E. O’Neill, D. Eberhard, J.M.W. Slack and D. Tosh
P002 Beta-cells can be derived from mesenchyme during pancreatic development
A. Rowan-Hull, W. Teague, S. Robinson and P. Johnson
P003 Biphasic induction of PDX-1 in mouse embryonic stem cells can mimic development of pancreatic beta-cells
A.S. Bernardo, S. Mason, H.M. Docherty, L. Vallier and K. Docherty
P004 Myt1 and Ngn3 form a feed forward expression loop to regulate endocrine differentiation
S. Wang, J. Hecksher-Sorensen, Y. Xu, P. Serup and G. Gu
P005 Ngn3 expression in the adult pancreas contributes to sufficient endocrine function
G. Gu, A. Zhao and Y. Xu
P006 Generation of insulin-synthesising pseudo-islets from adult stem cell cultures derived from human pancreas
A. Aldibbiat, G.N. Holliman, H. Al-Turaifi, S.C. Campbell, G.C. Huang and J.A.M. Shaw
P007 Amelioration of streptozotocin-induced diabetes in mice with cells derived from human marrow stromal cells
M. Zhao, S.A. Amiel, M. Rela, N. Heaton and G.C. Huang
P008 Differentiation of feeder-free human embryonic stem cells towards an endoderm lineage
E. Wright, M. Baxter, R. Oldershaw, S. Kimber and K. Cosgrove
P010 Functional properties of the common and Type 2 diabetes-associated R325W variant of the vesicular zinc transporter ZnT8
T. Nicolson and G.A. Rutter
P011 GLP-1 and GH-induced human islet cell proliferation
C. Bruun, T. Mandrup-Poulsen and N. Billestrup
P012 Beta-cells from embryonic extrahepatic biliary ducts
D. Eberhard, N.L. Chillingworth, J.R. Dutton, R.A. Coad, D. Tosh and J.M.W. Slack
P013 A conserved transcriptional programme specifies insulin-producing neurons in Drosophila
I. Miguel-Aliaga, S. Thor and A.P. Gould
P014 Streptozotocin induces insulin expression in the liver
N.L. Chillingworth, D. Tosh and J.M.W. Slack
P015 Reprogramming gall bladder epithelium into beta-like cells
R.A. Coad, D. Eberhard, J. Dutton, D. Tosh and J.M.W. Slack
P016 Role of nicotinic acid adenine dinucleotide phosphate (NAADP) in pancreatic beta cell stimulus-secretion coupling
E.A. Bellomo, S. Barg and G.A. Rutter
P017 A novel mutation in the ABCC8/SUR1 gene is linked to type 2 diabetes in adults
T. Nicolson, A.I. Tarasov, T.K. Taneja, S.A. Baldwin, J.M. Baldwin, J.P. Riveline, P. Froguel, M. Vaxillaire and G.A. Rutter
P018 Re-inventing the operon: identification of a novel mechanism of transcription regulation in beta cells
K. Bahar, R. Bartoov-Shifman and M.D. Walker
P019 Studies of Munc18 proteins mediating insulin exocytosis
S.A. Mandic, J.U. Johansson, M. Skelin, M. Rupnik, P.-O. Berggren and C. Bark
P020 Role of carboxypeptidase E in palmitate-induced beta-cell ER-stress and apoptosis
K.D. Jeffrey, E.U. Alejandro, T.B. Kalynyak, X. Hu, T. Yang, D.S. Luciani and J.D. Johnson
P021 Raf-1 signalling regulates pancreatic beta-cell survival and proliferation
E. Alejandro, J. Beith and J. Johnson
P022 Micro-array analysis of MIN6 beta-cell gene expression
D.S. Muller, M.J. Carvell, P.M. Jones and S.J. Persaud
P023 Bcl-2 regulates beta-cell metabolism and Ca2+ homeostasis
D.S. Luciani and J.D. Johnson
P024 Semi-automated ex-vivo pancreatic islet imaging and analysis in ZDF rats
J. Peel, J. Myatt, A. Marley, D. Smith and R. Mayers
P025 PAS-domain containing protein kinase (PASK) regulates glucagon secretion from pancreatic alpha-cells
G. da Silva Xavier and G.A. Rutter
P026 TCF7L2 controls insulin gene expression and insulin secretion
M.K. Loder, G. da Silva Xavier, A. McDonald and G.A. Rutter
P027 Characterization of human pancreatic islet niche
M. Banerjee, I. Virtanen, A. Lukinius, O. Korsgren, M. Hukkanen, Y. Kikkawa, Y.T. Konttinen and T. Otonkoski
P028 The role of kinesin light chains in insulin granule movement
A. McDonald, I. Leclerc, D.G. Hardie and G.A. Rutter
P029 Activation of AMP-activated protein kinase (AMPK) promotes glucagon secretion from pancreatic alpha cells
G. Sun, I. Leclerc and G.A. Rutter
P030 The regulation of pancreatic duodenum homeobox-1 (PDX-1) by Per-Arnt-Sim (PAS) kinase
A.N. Rong, G. da Silva Xavier, H.-X. Hao, F. Semplici, J. Rutter and G.A. Rutter
P031 Heterozygous missense insulin mutations in permanent early-infancy diabetes
M. Vaxillaire, M. Polak, A. Dechaume, H. Cavé, R. Scharfmann and P. Froguel
P032 Mutations in the proinsulin (INS) gene are a common cause of neonatal diabetes
E.L. Edghill, C. Boustred, S.E. Flanagan, A.-M. Patch, G.I. Bell, S. Ellard and A.T. Hattersley
P033 A potential role for HNF4A P1 transcripts in the development of normal beta-cell function?
L.W. Harries, J. Locke, B. Shields, K. Piper Hanley, N.A. Hanley, A. Steele, S. Ellard and A.T. Hattersley
P034 Identifying novel diabetes disease genes in patients with neonatal diabetes by homozygosity mapping
A.-M. Patch, S. Ellard and A. Hattersley
P035 COUP-TFII is negatively regulated by insulin and glucose via the Foxo1 and ChREBP controlled pathways
A. Perilhou, C. Tourrel-Cuzin, V. Fauveau, C. Postic, T. Kitamura and M. Vasseur-Cognet
P036 Preservation of islet mass by enhanced intracellular oxygen utilization
J. Stagner, R. Seelan, N. Parthasarathy and K. White
P037 Homeward bound – islet transplantation to the pancreas
J. Stagner, H. Rilo, B. Ahren, F. Sundler and K. White
P038 Trafficking of dense-core vesicles containing ZnT-8 during exocytosis in insulin-secreting beta cells
T.K. Taneja, T. Nicolson and G.A. Rutter
P039 A proteomic approach to identify proteins involved in endoplasmic reticulum stress in INS-1E cells
W. D’Hertog, L. Overbergh, C. Gysemans, A.K. Cardozo, E. Waelkens, D.L. Eizirik and C. Mathieu
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4 December 2007 Poster Session 2: 12:30-14:00
P040 Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T cell-induced cytotoxicity
A. Riboulet-Chavey, F. Diraison, L.K. Siew, F.S. Wong and G.A. Rutter
P041 MRI of the mouse pancreas
L.-W. Lee, P.-W. So and J.D. Bell
P042 A siRNA-based inhibition of STAT1 protects beta-cells against cytokine-induced apoptosis
F. Moore, J. Rasschaert, C. Mathieu and D.L. Eizirik
P043 miRNAs are potentially involved in post-transcriptional regulation of Bcl-2 family members after cytokine stimulation
L.G. Grunnet, C. Bang-Berthelsen, B. Kutlu, F. Johansson, D. Eizirik, F. Pociot and T. Mandrup-Poulsen
P044 Expression of a mutant, dominant negative form of TAK1 in insulin-secreting INS-1 cells reduces cytokine-induced apoptosis
J. Størling, N. Billestrup and T. Mandrup-Poulsen
P045 High-resolution 3D quantification of the development of insulitis and destruction of b-cell mass in the NOD mouse
T. Alanentalo, A.K. Nilsson, J. Sharpe, U. Ahlgren and D. Holmberg
P046 Improving survival and function of pancreatic islets using an adenoviral-driven super-repressor of NF-kappaB
H. Callewaert, C. Gysemans, J. Hagenbrock, J. Rasschaert, S. Lortz, D.L. Eizirik and C. Mathieu
P047 The effects of SOCS-3 on cytokine-induced chemokine expression in pancreatic beta-cells
M.L.B. Jacobsen, S.G. Rønn, C. Bruun, D. Eizirik, T. Mandrup-Poulsen and N. Billestrup
P048 Proteomic analysis of cytokine-induced dysfunction and death in insulin producing INS-1E cells: new insights into the pathways involved
W. D’Hertog, L. Overbergh, K. Lage, G.B. Ferreira, M. Maris, C. Gysemans, D.L. Eizirik, E. Waelkens and C. Mathieu
P049 beta-cell maturation enhances cytokine sensitivity via iron metabolism
M. Tonnesen, L.G. Grunnet, J. Friberg, N. Billestrup, F. Pociot and T. Mandrup-Poulsen
P050 Epigenetic variants of Type 1 diabetes susceptibility genes
H. Beyan, V.K. Rakyan, M.I. Hawa, S. Beck and R.D.G. Leslie
P051 Enteroviral vp1 expression in Type 1 diabetes
S.J. Richardson, A. Willcox, A.J. Bone, A.K. Foulis and N.G. Morgan
P052 Differential use of calcium stores in reactive oxygen species (ROS)- dependent pancreatic beta-cell death
D. Watson, E. Kinsey, S.A. Hazelwood, J.H.B. Scarpello and A.C. Loweth
P053 Induction of cell cycle inhibitor and proapoptotic genes in human beta cells exposed to hyperglycemia
H. Katsuta, R. Katsuta, L. Duran, L. Marselli, S. Bonner-Weir and G.C. Weir
P054 An immunohistochemical study of insulitis in early onset Type 1 diabetes
A. Willcox, S. Richardson, A.J. Bone, A.K. Foulis and N.G. Morgan
P055 Regulation of the aryl hydrocarbon receptor nuclear translocator (ARNT) gene expression by the carbohydrate-responsive element binding protein (ChREBP)
N.A. Noordeen, T. Khera, G. da Silva Xavier, G.A. Rutter and I. Leclerc
P056 IL-1-antagonism prevents IL-1-mediated inhibition of striated muscle gene-expression involved in antigen-presentation and differentiation in Type 2 diabetes
L.A. Berchtold, C.M. Larsen, J. Størling, M. Faulenbach, N. Billestrup, M.Y. Donath and T. Mandrup-Poulsen
P057 Does aminoacetone accumulation contribute to pancreatic beta-cell death in diabetes?
A. Sartori, C.M. Mano, H.M. Malpartida, F. Dutra, M.C. Sogayar and E.J.H. Bechara
P058 Exposure to low glucose increases mitochondrial superoxide production and mitochondrial damage in pancreatic beta-cells
K.J. Morten, A. Borzychowski, S. Cookson and J. Poulton
P059 Induction by glucose of beta-cell genes involved in glucose sensing requires sterol regulatory element binding protein1 (SREBP1)
F. Diraison, M.A. Ravier, H. Shimano and G.A. Rutter
P060 Elevated intracellular Acyl-CoAs increase the open probability of KATP channels in intact pancreatic beta-cells
N.J. Webster, G.J. Searle and P.E. Light
P061 PKCepsilon dependant regulation of insulin secretion
J.G. Burchfield, C. Schmitz-Peiffer, C.J. Mitchell and T. Biden
P062 Investigation of lipid accumulation induced changes in pancreatic beta-cells using proteomic approaches
M. McCormack, D. Corry, M. Lewis, J. Hancock, K. Heesom and A. Varadi
P063 Environmental contaminants, polychlorinated biphenyls (PCBs), cause beta-cell death: an effect potentiated by fatty acids
J.G. Mabley, I.K. Chadbourn, A. Wale and J. Cunningham
P064 PAS kinase is regulated by glucose independently of cellular glucose metabolism
F. Semplici and G.A. Rutter
P065 Hypoxia increases production of pure MSCs from adipose tissue and bone marrow: potential implications for their use for beta cell replacement
M.G. Valorani, P. Tropel, W.R. Otto, C. Guglielmi, C.P. Khoo, M.R. Alison and P. Pozzilli
P066 Transdifferentiation of pancreatic ductal cells to beta cells: a model derived from the analysis of hnf6-/- mice
E. Heinen, F. Lemaigre and P. Jacquemin
P067 Beta-cell survival during glucolipotoxic conditions is enhanced by over expression of hormone-sensitive lipase
C. Klint, R. Kulkarni, C. Holm and M. Sörhede Winzell
P068 GLP-1 secreted from alpha cells, is up-regulated in islets of mice deficient in PC2
N.M. James, L.E. Pritchard, D. Livesey, D.M. Smith and A. White
P070 Isolation, characterisation and prospects for use of endothelial progenitor cells to repair pancreatic damage in diabetes
C.P. Khoo, M.G. Valorani, M. Brittan, M.R. Alison, U. Johansson and P. Pozzilli
P071 Molecular mechanisms involved in IL-1beta and TNF-alpha-induced pancreatic beta-cell-death
F. Ortis, P. Pirot, N. Naamane, A.Y. Kreins, J. Rasschaert, F. Moore and D.L. Eizirik
P072 Maternal microchimerism in the human pancreas
K.M. Gillespie, B. van Zyl, A.K. Foulis, R.R. de Krijger, J.L. Nelson and E.A.M. Gale
P073 The inflammatory response in beta-cells: a radical approach
J. Friberg, F. Pociot, M. Tonnesen and A.E. Karlsen
P074 Suppression of TRAF2 expression by siRNA reduces cytokine-mediated apoptosis in insulin-secreting INS-1E cells
M.C. Prause, J. Størling, N. Billestrup and T. Mandrup-Poulsen
P075 Free fatty acids induce endoplasmic reticulum stress via calcium depletion in pancreatic beta-cells
D.A. Cunha, L. Ladriere, A. Herchuelz, E. Bellomo, G. Rutter, F. Ortis, D.L. Eizirik and M. Cnop
P076 A quantitative 3D atlas to pancreas morphogenesis in the mouse
A. Hörnblad, C.E. Loren, H. Semb and U. Ahlgren
P077 Reg1-alpha: potential marker of beta-cell regeneration?
C. Guglielmi, F. Battistoni, L. Valente, E. Astorri, M.G. Valorani, P. Pozzilli and IMDIAB Group
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