A Biochemical Society Focused Meeting
Emerging research has provided evidence of a fundamental link between cytoskeletal structures such as centrioles and cilia in the regulation of DNA repair and genomic instability.
This is highlighted by an increasing number of cancers/syndromes with clear ciliary connections such as Birt-Hogg-Dube syndrome, Von Hippel-Lindau disease and Tuberous Sclerosis. Not only do cilia normally regulate many of the cellular signalling pathways commonly perturbed in cancer, but the ability to form cilia is lost in many transformed cells and it has been shown that the primary cilium can both mediate and suppress Hedgehog pathway-dependent tumourigenesis.
As the pivotal link between tumourigenesis and cilia function is emerging, this meeting will represent a timely opportunity to bring together researchers from the fields of cancer and cytoskeletal/cilia biology.
The format will allow invitation of speakers in cilia and cytoskeletal biology and speakers with specific interest in how these cellular processes influence the carcinogenesis process. Structured thematic sessions with talks describing fundamental cellular processes in cilia, cytoskeletal and tumour biology and how dysregulation of these processes can initiate disease, will culminate with talks aimed at the interplay between cilia, cytoskeleton and cancer and how these processes can be targeted therapeutically.
- Cilia and cancer
- Cytoskeleton and cancer
Topics covered in this meeting will be published in Biochemical Society Transactions
Abstract deadline: 4 March 2016
Abstract submission is now closed.
Earlybird registration deadline: 4 March 2016
Registration is now open.
Student Bursaries and Full and Early Career Bursaries are available for this meeting.
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Invited Speakers Include:
-Andrew Fry (University of Leicester, United Kingdom)
Cells Early Career Research Award Winner - Medal Lecture
-Bungo Akiyoshi (University of Oxford, United Kingdom)
-Carsten Janke (Institut Curie, France)
-Erich Nigg (University of Basel, Switzerland)
-Fanni Gergely (University of Cambridge, United Kingdom)
-Inke Nathke (University of Dundee, United Kingdom)
-Kim Dale (University of Dundee, United Kingdom)
-Mónica Bettencourt-Dias (Instituto Gulbenkian de Ciência, Portugal)
-Pleasantine Mill (IGMM Edinburgh, United Kingdom)
-Rachel Giles (University Medical Center Utrecht, Netherlands)
-Shehab Ismail (Cancer Research Glasgow, United Kingdom)
-Toby Hurd (IGMM Edinburgh, United Kingdom)
View the scientific programme here