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EMBO Conference - Helicases and nucleic acid-based machines: Structure, mechanism and regulation and roles in human disease: Sponsored by Harden Conferences

23—28 July 2017

Kloster Banz Conference Centre, nr Bamberg, Germany



 

Organizers:
Dagmar Klostermeier (University of Muenster, Germany)
Ralf Seidel (Universität Leipzig, Germany)
Piero Bianco (University at Buffalo, USA)
Sunday 23 July 2017
17:00 - 18:00 Registration

20:00 - 21:00
Keynote speaker: How one chromosome makes two; the role of an SMC molecular machine
David Sherratt (Oxford, UK)

Session 1: RNA helicase function and regulation

Monday 24 July 2017
09:00 - 09:30
Biochemical and Biological Function of the DEAD-box RNA Helicase Ded1p
Eckhard Jankowsky (Case Western University, USA)
09:30 - 09:45
Kinetic studies of DEAH helicases and their cofactors in single molecule assay
Selected oral communication: Saurabh Raj
09:45 - 10:00
Interplay of translation initiation factors eIF4A, eIF4B and eIF4G: a single-molecule study
Selected Oral Communication - Alexandra Andreou
10:00 - 10:15
Activation of RIG-I by hairpin RNA
Selected Oral Communication - Neelam Shah
10:15 - 10:45
Long-distance regulation of the spliceosomal Brr2 RNA helicase
Markus Wahl (Free University Berlin, Germany)
10:45 - 11:30 Refreshment Break

11:30 - 12:00
Anna Pyle (Yale, USA)
12:00 - 12:30
MechanisticStudies of theInnateImmuneReceptor RIG-I Helicase
Smita Patel (Rutgers University, USA)
12:30 - 14:00 Lunch

Session 2: Helicase structure and mechanism

Monday 24 July 2017
14:00 - 14:30
Large Conformational Changes upon UvrD Dimerization and Helicase Activation
Tim Lohman (Washington University, USA)
14:30 - 14:45
Pif1-catalyzed unfolding of G-quadruplex DNA
Selected Oral Communication - Alicia Byrd
14:45 - 15:00
Irc3 is a novel branch migration enzyme in S.cerevisiae mitochondria
Selected Oral Communication - Ilja Gaidutsik
15:00 - 15:15
Targeting eIF4a with small molecules
Selected Oral Communication - Laurence Arnold
15:15 - 15:30
A winged helix domain confers specificity to the Escherichia coli PriA-DNA fork interaction
Selected Oral Communication - Tricia Windgassen
15:30 - 16:00
Taekjip Ha (Johns Hopkins University, USA)
16:00 - 16:30 Refreshment Break

16:30 - 17:00
Cross-talk within a functional INO80 complex dimer regulates nucleosome sliding
Dale Wigley (Imperial College London, UK)
17:00 - 17:15
The cryo-EM structure of human TFIIH
Selected Oral Communication - Basil Greber
17:15 - 17:30
Cost of proofreading during leading and lagging strand DNA synthesis
Selected Oral Communication - Anupam Singh
17:30 - 18:00
Stephen Kowalczykowski (UC Davis, USA)
18:00 - 19:00 Poster Session 1

Session 3: RNP remodeling

Tuesday 25 July 2017
09:00 - 09:30
The Roles of the DEAD box protein Rok1 and its Binding Partner Rrp5 in Coordinating the Assembly of 40S and 60S Ribosomal Subunits
Katrin Karbstein (Scripps Florida, USA)
09:30 - 09:45
Cryo-EM structures of the catalytic spliceosome elucidate remodelling by a DEAH-box helicase
Selected Oral Communication - Sebastian Fica
09:45 - 10:00
DEAD box helicase DDX17 potentiates alternative splicing in HIV-1 replication
Selected Oral Communication - Nyarie Sithole
10:00 - 10:15
The LOTUS domain is a novel, conserved DEAD-box RNA helicase regulator of the animal germline
Selected Oral Communication - Mandy Jeske
10:15 - 10:45
Diverse functions of RNA helicases in ribosome biogenesis
Markus Bohnsack (University of Goettingen, Germany)
10:45 - 11:30 Refreshment Break

11:30 - 12:00
Mechanistic studies of DEAD-box proteins as RNA helicases and chaperones
Rick Russell (University of Texas, USA)
12:00 - 12:30
Novel insight into the formation and function of cytoplasmic processing bodies
Karsten Weis (ETH Zurich, Switzerland)
12:30 - 14:00 Lunch

Session 4: DNA helicase function and regulation

Tuesday 25 July 2017
14:00 - 14:30
Why do so many helicases interact with RNA polymerase?
Mark Dillingham (University of Bristol, UK)
14:30 - 14:45
Real time collision of helicase and polymerase with G-quadruplex
Selected Oral Communication - Vincent Croquette
14:45 - 15:00
Auxiliary ATP binding sites power rapid unwinding by RecBCD
Selected Oral Communication - Rani Zananiri
15:00 - 15:30
Single-molecule studies of FeS-containing DNA helicases: kinetics, conformational dynamics and molecular mechanisms
Maria Spies (University of Iowa, USA)
15:30 - 16:00
RNA helicases mediate unfolding of G-quadruplex nucleic acids
Kevin Raney (University of Arkansas, USA)
16:00 - 16:30 Refreshment Break

16:30 - 17:00
Binding and processing of unusual substrates by DNA helicases
James Keck (University of Wisconsin, USA)
17:00 - 17:15
Unique structural features govern processivity of Upf1-like helicases
Selected Oral Communication - Joanne Kanaan
17:15 - 17:30
Unwinding and re-winding by individual Pif1 helicase family members
Selected Oral Communication - Roberto Galletto
17:30 - 18:00
Karl-Peter Hopfner (LMU Munich, Germany)
18:00 - 19:00 Poster Session 2

Session 5: Replication, recombination and repair

Wednesday 26 July 2017
09:00 - 09:30
Recognition and reversal of stalled replication forks
Brandt Eichman (Vanderbilt University, USA)
09:30 - 09:45
Single-molecule FRET experiments on PARP-1 binding to DNA single-strand breaks
Selected Oral Communication - Eleni Kallis
09:45 - 10:00
Design principles for a dynamic molecular machine and the bacterial replisome
Selected Oral Communication - Nicholas Dixon
10:00 - 10:15
Coordinated actions of four ATPase sites on UvrA2 during initiation of Nucleotide Excision Repair
Selected Oral Communication - Manju Hingorani
10:15 - 10:45
Pif1 helicase function at G-quadruplexes is supported by other G4 interacting proteins
Katrin Päschke (University Medical Center Groningen, The Netherlands)
10:45 - 11:30 Refreshment Break

11:30 - 12:00
RecQ4, the odd one out in the RecQ helicase family
Caroline Kisker (University of Wuerzburg, Germany)
12:00 - 12:30
Molecular and Genetic Studies of FANCJ Helicase Implicated in Fanconi Anemia and Cancer
Robert Brosh (NIH, USA)
12:30 - 19:30 Packed Lunch and free time

19:30 BBQ night

Session 6: RNA helicases and gene regulation

Thursday 27 July 2017
09:45 - 10:00
DHX15 regulates CMTR1-dependent gene expression and cell proliferation
Selected Oral Communication - Francisco Inesta-Vaquera
10:00 - 10:15
A novel function for RNA-dependent DEAD-box ATPases in the formation of membrane-less compartments through the regulation of phase transitions
Selected Oral Communication - Maria Hondele
10:15 - 10:45
The DEAD-box RNA Helicase Dbp2 Integrates Nutrient Availability with Regulation of Cellular Metabolism
Elizabeth Tran (Purdue University, USA)
10:45 - 11:30 Refreshment Break

11:30 - 12:00
Activating the spliceosome for catalysis by the Ski2-like ATPase Brr2
Jon Staley (University of Chicago, USA)
12:00 - 12:30
The DEAD-box helicase eIF4A3 and the complexity of mRNP assembly
Herve Le Hir (École normale Supérieure, FR)
12:30 - 14:00 Lunch

Session 7: Non-conventional helicase function

Thursday 27 July 2017
14:00 - 14:30
Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes
Tom Owen Hughes (University of Dundee, UK)
14:30 - 14:45
Regulatory architecture and logic of chromatin remodelers
Selected Oral Communication - Cedric Clapier
14:45 - 15:15
Following the pathways to DNA cleavage taken by ATP-dependent restriction enzymes
Mark Szczelkun (University of Bristol, UK)
15:15 - 15:30
CgII cleaves DNA using a mechanism distinct from other ATP-dependent restriction endonucleases
Selected Oral Communication - Mindaugas Zaremba
15:30 - 15:45
A novel function of the Rrm3 helicase in restricting DNA synthesis during replication stress
Selected Oral Communication - Kristina Schmidt
15:45 - 16:15
Cryo-EM studies of ribonucleoprotein complexes that are beyond the reach of X-ray crystallography
Thi Hoang Duong Nguyen (UC Berkeley, U.S.A.)
16:15 - 16:30 Business Meeting

16:30 - 17:00 Refreshment Break

17:00 - 19:00 Summary poster session and conference close

Friday 28 July 2017
10:00 Departure