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The Biochemical Society provides an extensive range of events, including scientific conferences, outreach activities, medal lectures and policy and education events.  

 

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Metabolic Drivers of Immunity

25 March 2015

Aston University, UK



Meeting Background

Obesity and nutrient excess are associated with inflammatory phenotypes and immune dysfunction. This conference will bring together key players to present emerging research on the importance of metabolism to normal maturation and differentiation of immune cells. Does high glucose directly affected immune phenotype? Does epigenetic memory of hyperglycaemia promote chronic inflammation? By integrating our latest understanding of metabolic control, spanning from biochemistry to immunology, the legacy of this meeting will lie in improved and targeted metabolic approaches to modulate immune dysfunction. 

 

 

Topics:


  • Mitochondrial function and biogenesis in immune cells
  • Nutrient sensing pathways and immunity
  • Metabolism and innate immunity
  • Metabolism and adoptive immunity

Organizers:
Helen Griffiths (Aston University, United Kingdom)
Andrew Devitt (Aston University, United Kingdom)
James Brown (Aston University, United Kingdom)
Wednesday 25 March 2015
09:00 - 09:50 Registration

09:50 - 10:00 Welcome

10:00 - 10:40
Metabolic signatures linked to macrophage polarization: From glucose metabolism to oxidative phosphorylation
Lisardo Boscá (Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), Spain)
10:40 - 11:00 Coffee/tea break

11:00 - 11:30
A Macrophage Cytokine Causes Impaired Glucose Homeostasis and Reduced Lifespan in Drosophila Fed a Lipid-Rich Diet
Frederic Geissmann (King's College London, United Kingdom)
11:30 - 11:45
Enteroendocrine cells- key orchestrators of intestinal immunity
Selected oral communication - John Worthington (University of Manchester, United Kingdom)
11:45 - 12:15
mTOR-independent regulation of senescent human CD8+ T cellsvbNewLine
Sian Henson (University College London, United Kingdom)
12:15 - 12:30
Liver-X-Receptor activation affects plasma membrane lipid composition and immune function of human CD4+ T cells
Selected oral communication - Kirsty Waddington (University College London, United Kingdom)
12:30 - 13:00 Flash poster presentation

13:00 - 14:30 Lunch, posters session and Networking

14:30 - 14:45
mTORC1-dependent metabolic reprogramming is a prerequisite for Natural Killer cell effector function
Selected oral communication - David Finlay (Trinity College Dublin, Ireland)
14:45 - 15:00
Anti-inflammatory function of HIF-1a and glycolysis in Dendritic cells
Selected oral communication - Simon Lawless (Trinity College Dublin, Ireland)
15:00 - 15:30 Coffee/tea break

15:30 - 15:45
Selected oral communication - Age-associated changes in fatty acid profile during ageing promote pro-inflammatory monocyte polarisation via PPARγ
Chathyan Pararasa (Aston University, UK)
15:45 - 16:15
Lipid metabolism and T cell plasticity: can manipulating membrane lipid profiles restore T cell function in autoimmunity?
Elizabeth Jury (University College London, United Kingdom)
16:15 - 17:00
Myc and the metabolic maintenance of asymmetric T cell division
Doug Green (St Jude's Children's Hospital, U.S.A.)
17:00 - 17:50 Drinks reception, posters session and Networking

17:50 - 18:00 Closing remarks