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Cilia, Cytoskeleton and Cancer

25—26 April 2016

IGMM, Edinburgh, UK



Meeting Background


Over the past decade, intensive research has focused on the cytoskeleton and primary cilium at a structural and functional level. It is evident that cilia are sensory organelles, playing a pivotal role in both development and homeostasis, responding to both mechanical and chemical stimuli and are key regulators of multiple signalling pathways including Hedgehog, cAMP, MAPK, Wnt and calcium. Given the diverse range of cellular mechanisms regulated by cilia - cytoskeletal remodelling, proliferation and differentiation; an ever expanding group of genetic diseases, the ciliopathies, have been identified whose aetiology is defined by ciliary dysfunction.

 

Emerging research has established a fundamental link between cytoskeletal structures such as centrioles and cilia in the regulation of DNA repair and genomic instability, highlighted by an increasing number of cancers/syndromes with clear ciliary connections such as Birt-Hogg-Dube syndrome, Von Hippel-Lindau disease and Tuberous Sclerosis. Not only do cilia normally regulate many of the cellular signalling pathways commonly perturbed in cancer, but the ability to form cilia is lost in many transformed cells and indeed primary cilium can both mediate and suppress Hedgehog pathway-dependent tumourigenesis.

 

As the pivotal link between tumourigenesis and cilia function is emerging, this meeting will represent a timely opportunity to bring together researchers from the fields of cancer and cytoskeletal/cilia biology. There will be structured sessions describing fundamental cellular processes in cilia, cytoskeletal and tumour biology and how dysregulation can initiate disease. The meeting will culminate with talks aimed at the interplay between cilia, cytoskeleton and cancer and how these processes can be targeted therapeutically.


Organizers:
Susan Farrington (IGMM Edinburgh, United Kingdom)
Toby Hurd (IGMM Edinburgh, United Kingdom)
Monday 25 April 2016
08:45 - 09:30 Registration

09:30 - 09:40 Introduction

Cilia in Development and Disease

Monday 25 April 2016
09:40 - 10:20
Regulation of cell fate choice in neuroectoderm progenitors by crosstalk between Notch and Sonic Hedgehog pathways
Kim Dale (University of Dundee, United Kingdom)
10:20 - 10:35
The role of cilia in acquired tyrosine kinase inhibitor resistance
Selected Oral Communication- Barbara Tanos (The Institute of Cancer Research, University of London, United Kingdom)
10:35 - 10:50
TGF-β-modulation of primary cilia and hedgehog signalling promotes cancer associated fibroblast activation
Selected Oral Communication- Robin Delaine-Smith (Queen Mary University of London, United Kingdom)
10:50 - 11:20 Tea/Coffee Break

Cilia in Development and Disease (Continued)

Monday 25 April 2016
11:20 - 12:00
A multi-system approach to define regulatory networks necessary for ciliary motility.
Pleasantine Mill (IGMM Edinburgh, United Kingdom)
12:00 - 12:15
Micrognathia in ciliopathic models
Selected Oral Communication- Hadeel Al-Lami (King's College London, United Kingdom)
12:15 - 12:30
The E3 ubiquitin ligase UBR5 is a novel regulator of primary cilia formation
Selected Oral Communication- Robert Shearer (The Garvan Institute of Medical Research, Australia)
12:30 - 12:45
The role of primary cilia in the molecular pathogenesis of phaeochromocytoma
Selected Oral Communication- Sam O'Toole (William Harvey Research Institute, United Kingdom)
12:45 - 14:00 Lunch/ Poster Session 1

Cilia in Disease

Monday 25 April 2016
14:00 - 14:40
Disease Mechanism in Retinitis Pigmentosa Type II
Toby Hurd (IGMM Edinburgh, United Kingdom)
14:40 - 15:55
Using iPSC to understand retinal ciliopathy disease mechanisms and develop therapies
Selected Oral Communication- Michael Cheetham (UCL Institute of Ophthalmology, United Kingdom)
14:55 - 15:10
New LKB1 function in the primary cilium
Selected Oral Communication- Michael Sebbagh (CRCM_INSERM, France)
15:10 - 15:40 Tea/Coffee Break

Role of Modification and Cilia

Monday 25 April 2016
15:40 - 16:20
The role of Arl2 and Arl3 in sorting lipid modified proteins to the cilia
Shehab Ismail (Cancer Research Glasgow, United Kingdom)
16:20 - 16:35
ATR promotes cilia signalling: links to developmental impacts
Selected Oral Communication- Teresa Casar Tena (Ulm University, Germany)
16:35 - 16:50
The role of ATMIN in Autosomal Recessive Polycystic Kidney Disease (ARPKD)
Selected Oral Communication- Paraskevi Goggolidou (Kingston University, United Kingdom)
16:50 - 17:30
Dissecting the roles of tubulin-modifying enzymes in mammalian cilia
Carsten Janke (Institut Curie, France)
17:30 - 18:10 Ask the Experts Session (for PhD Students and Early Career Researchers)

17:30 - 18:20 Drinks Reception

18:10 - 20:00 Whisky Tasting/ Haggis Tasting

Centrosomes in Development and Disease

Tuesday 26 April 2016
09:00 - 09:40
Centrosomes in Development
Mónica Bettencourt-Dias (Instituto Gulbenkian de Ciência, Portugal)
09:40 - 09:55
Hedgehog signalling in cytotoxic T cells
Selected Oral Communication- Maike de la Roche (Cancer Research UK Cambridge Institute, United Kingdom)
09:55 - 10:10
The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability
Selected Oral Communication- Claire Heride (University of Liverpool, United Kingdom)
10:10 - 10:50
Centrosome dysfunction and its link to primordial dwarfism
Fanni Gergely (University of Cambridge, United Kingdom)
10:50 - 11:20 Tea/Coffee Break

Cells Early Career Research Award Medal

Tuesday 26 April 2016
11:20 - 12:10
Cells Early Career Research Award Winner - Medal Lecture
Unconventional kinetochores
Bungo Akiyoshi (University of Oxford, United Kingdom)
12:10 - 13:00
The centrosome duplication cycle: impact of centrosome aberrations on microcephaly and cancer
Keynote Speaker- Erich Nigg (University of Basel, Switzerland)
13:00 - 14:00 Lunch/Poster Session 2

Cilia, Cytoskeleton and Cancer

Tuesday 26 April 2016
14:00 - 14:40
Mutations in ciliary outer arm DNAAF1 predispose to testicular germ cell tumors
Rachel Giles (University Medical Center Utrecht, Netherlands)
14:40 - 15:20
EML proteins in cell cycle-dependent microtubule regulation and cancer
Andrew Fry (University of Leicester, United Kingdom)
15:20 - 15:50 Tea/Coffee Break

Cytoskeleton and Cancer Stem cells

Tuesday 26 April 2016
15:50 - 16:00
Cytoskeleton modifying proteins as targets for tumor therapy
Selected Oral Communication- Sabine Windhorst (Universitätsklinikum Hamburg-Eppendorf, Germany)
16:05 - 16:45
Post-mitotic positioning directs exit from the stem cell niche in intestinal crypts
Inke Nathke (University of Dundee, United Kingdom)
16:45 - 17:00 Concluding remarks/ Prizes